Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
AI Summary:
The brain's mechanical behavior has been challenging to model, with a lack of understanding on how it responds to mechanical loading. Finite element simulations were performed to study the response of human brain white and gray matter specimens under cyclic compression-tension loading and compression-relaxation experiments.AI Topics:
The brain is arguably the most complex human organ and modelling its mechanical behaviour has challenged researchers for decades. There is still a lack of understanding on how this multiphase tissue responds to mechanical loading and how material parameters can be reliably calibrated. While previous viscoelastic models with two relaxation times have successfully captured the response of brain tissue, the Theory of Porous Media provides a continuum mechanical framework to explore the underlying physical mechanisms, including interactions between solid matrix and free-flowing interstitial fluid. Following our previously published experimental testing protocol, here we perform finite element simulations of cyclic compression–tension loading and compression–relaxation experiments on human brain white and gray matter specimens. The solid volumetric stress proves to be a crucial factor for the overall biphasic tissue behaviour as it strongly interferes with porous effects controlled by the permeability. An inverse parameter identification reveals that poroelasticity alone is insufficient to capture the time-dependent material behaviour, but a poro-viscoelastic formulation captures the response of brain tissue well. We provide valuable insights into the individual contributions of viscous and porous effects. However, due to the strong coupling between porous, viscous, and volumetric effects, additional experiments are required to reliably determine all material parameters.
Greiner, Alexander
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
See full publications listReiter, Nina
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
See full publications listHinrichsen, Jan
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
See full publications listKainz, Manuel P.
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
See full publications listSommer, Gerhard
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
See full publications listHolzapfel, Gerhard A.
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
See full publications listSteinmann, P.
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
Steinmann, Paul and Schmidt, Ina and Pivonka, Peter and Papastavrou, Areti (2024) A computational two-scale approach to cancellous bone remodelling. Advanced Modeling and Simulation in Engineering Sciences, 11: 13. ISSN 2213-7467
Moreno-Mateos, Miguel Angel and Steinmann, Paul (2024) Configurational force method enables fracture assessment in soft materials. Journal of the Mechanics and Physics of Solids, 186: 105602. ISSN 0022-5096
See full publications listComellas, Ester
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
See full publications listBudday, Silvia
Author
Greiner, Alexander and Reiter, Nina and Hinrichsen, Jan and Kainz, Manuel P. and Sommer, Gerhard and Holzapfel, Gerhard A. and Steinmann, Paul and Comellas, Ester and Budday, Silvia (2024) Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters! Interface Focus, 14 (6): 20240026. ISSN 2042-8901
See full publications listAvailable under License Creative Commons Attribution.
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