Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
AI Summary:
The TOURISM study aimed to characterise patients with uterine sarcoma. The study found that nearly half of the patients received at least one line of chemotherapy, and that survival varied significantly by stage at diagnosis.AI Topics:
Background: Although rare, uterine sarcomas account for a high proportion of uterine cancer mortality. Treatment options and robust trial data are limited.
Objectives: The TOURISM study (Treatment Outcomes in UteRIne SarcoMa) is a UK-wide study by the National Oncology Trainees Collaborative for Healthcare Research which aimed to characterise this patient cohort.
Design: A retrospective descriptive cohort study. Patients with carcinosarcomas/mixed Mullerian tumours, non-uterine gynaecological sarcomas and uterine metastases were excluded. Routine clinical data, including general patient demographics, diagnosis, treatment and outcomes, were collated and pseudonymised.
Setting: Patients diagnosed with uterine sarcoma in the UK National Health Service between 1 January 2008 and 31 December 2017 were identified from electronic records.
Participants: A total of 406 patients from eight centres were eligible for inclusion.
Results: The median age at diagnosis was 56 years, with leiomyosarcoma the most common diagnosis (54.4%). The majority (57.9%) were diagnosed at the International Federation of Gynecology and Obstetrics stage I, with 19.7% diagnosed at stage IV. Nearly half (45.2%) of the patients received at least one line of chemotherapy, of which most (81.0%) received doxorubicin first-line. In the stage I group 7.4% received adjuvant chemotherapy and 15.0% received adjuvant radiotherapy. Median overall survival was 37 months; however, survival varied significantly by stage at diagnosis (stage I: 105 months; stage II: 33 months; stage III: 19 months; stage IV: 14 months).
Conclusions: Our data highlight the diversity in patient management in uterine sarcoma and a marked survival advantage for patients diagnosed with stage I disease. These data highlight the importance of a multidisciplinary approach and describe real-world trends in systemic therapies, radiotherapy and surgical treatment in this rare cancer type.
Mactier, Karen
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listBaxter, Mark
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
Baxter, Mark and Spender, Lindsay and Cairns, David and Walsh, S. and Oparka, R. and Porter, R. J. and Bray, S. and Skinner, G. and King, S. and Turbitt, J. and Collinson, D. and Miedzybrodzka, Z. H. and Jellema, G. and Logan, G. and Kennedy, Richard and Turkington, Richard and McLean, Mairi H. and Swinson, D. and Grabsch, H. I. and lord, simon and Seymour, Matthew and Hall, P. S. and Petty, R. D. (2024) An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma. ESMO Open, 9 (5): 103450. ISSN 2059-7029
See full publications listPeters, A.L.
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
Peters, A.L. and Hall, P.S. and Jordan, L.B. and Soh, F.Y. and Hannington, L. and Makaranka, S. and Urquhart, G. and Vallet, M. and Cartwright, D. and Marashi, H. and Elsberger, B. (2024) Enhancing clinical decision support with genomic tools in breast cancer: a Scottish perspective. Breast, 75: 103728. ISSN 0960-9776
Malviya, Gaurav and Lannagan, Tamsin R.M. and Johnson, Emma and Mackintosh, Agata and Bielik, Robert and Peters, Adam and Soloviev, Dmitry and Brown, Gavin and Jackstadt, Rene and Nixon, Colin and Gilroy, Kathryn and Campbell, Andrew and Sansom, Owen J. and Lewis, David Y. (2024) Noninvasive stratification of colon cancer by multiplex PET imaging. Clinical Cancer Research, 30 (8). pp. 1518-1529. ISSN 1078-0432
See full publications listFair, Katherine
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listHannington, L.
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
Peters, A.L. and Hall, P.S. and Jordan, L.B. and Soh, F.Y. and Hannington, L. and Makaranka, S. and Urquhart, G. and Vallet, M. and Cartwright, D. and Marashi, H. and Elsberger, B. (2024) Enhancing clinical decision support with genomic tools in breast cancer: a Scottish perspective. Breast, 75: 103728. ISSN 0960-9776
See full publications listRobertson, James
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listWood, Georgina
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listSarwar, Asma
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listBishr, Mai
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listWebb, Rebekah
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listAl-Zubaidi, Mohammed
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listEastlake, Leonie
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listLankester, Kate
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listMcInerney, Samuel
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listCreedon, Helen
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listStillie, Alison
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
See full publications listPurshouse, Karin
Author
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055
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