Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

Abstract

Background: Although rare, uterine sarcomas account for a high proportion of uterine cancer mortality. Treatment options and robust trial data are limited.

Objectives: The TOURISM study (Treatment Outcomes in UteRIne SarcoMa) is a UK-wide study by the National Oncology Trainees Collaborative for Healthcare Research which aimed to characterise this patient cohort.

Design: A retrospective descriptive cohort study. Patients with carcinosarcomas/mixed Mullerian tumours, non-uterine gynaecological sarcomas and uterine metastases were excluded. Routine clinical data, including general patient demographics, diagnosis, treatment and outcomes, were collated and pseudonymised.

Setting: Patients diagnosed with uterine sarcoma in the UK National Health Service between 1 January 2008 and 31 December 2017 were identified from electronic records.

Participants: A total of 406 patients from eight centres were eligible for inclusion.

Results: The median age at diagnosis was 56 years, with leiomyosarcoma the most common diagnosis (54.4%). The majority (57.9%) were diagnosed at the International Federation of Gynecology and Obstetrics stage I, with 19.7% diagnosed at stage IV. Nearly half (45.2%) of the patients received at least one line of chemotherapy, of which most (81.0%) received doxorubicin first-line. In the stage I group 7.4% received adjuvant chemotherapy and 15.0% received adjuvant radiotherapy. Median overall survival was 37 months; however, survival varied significantly by stage at diagnosis (stage I: 105 months; stage II: 33 months; stage III: 19 months; stage IV: 14 months).

Conclusions: Our data highlight the diversity in patient management in uterine sarcoma and a marked survival advantage for patients diagnosed with stage I disease. These data highlight the importance of a multidisciplinary approach and describe real-world trends in systemic therapies, radiotherapy and surgical treatment in this rare cancer type.

People
Mactier, Karen
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Baxter, Mark
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

Baxter, Mark and Spender, Lindsay and Cairns, David and Walsh, S. and Oparka, R. and Porter, R. J. and Bray, S. and Skinner, G. and King, S. and Turbitt, J. and Collinson, D. and Miedzybrodzka, Z. H. and Jellema, G. and Logan, G. and Kennedy, Richard and Turkington, Richard and McLean, Mairi H. and Swinson, D. and Grabsch, H. I. and lord, simon and Seymour, Matthew and Hall, P. S. and Petty, R. D. (2024) An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma. ESMO Open, 9 (5): 103450. ISSN 2059-7029

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Peters, A.L.
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

Peters, A.L. and Hall, P.S. and Jordan, L.B. and Soh, F.Y. and Hannington, L. and Makaranka, S. and Urquhart, G. and Vallet, M. and Cartwright, D. and Marashi, H. and Elsberger, B. (2024) Enhancing clinical decision support with genomic tools in breast cancer: a Scottish perspective. Breast, 75: 103728. ISSN 0960-9776

Malviya, Gaurav and Lannagan, Tamsin R.M. and Johnson, Emma and Mackintosh, Agata and Bielik, Robert and Peters, Adam and Soloviev, Dmitry and Brown, Gavin and Jackstadt, Rene and Nixon, Colin and Gilroy, Kathryn and Campbell, Andrew and Sansom, Owen J. and Lewis, David Y. (2024) Noninvasive stratification of colon cancer by multiplex PET imaging. Clinical Cancer Research, 30 (8). pp. 1518-1529. ISSN 1078-0432

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Fair, Katherine
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Hannington, L.
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

Peters, A.L. and Hall, P.S. and Jordan, L.B. and Soh, F.Y. and Hannington, L. and Makaranka, S. and Urquhart, G. and Vallet, M. and Cartwright, D. and Marashi, H. and Elsberger, B. (2024) Enhancing clinical decision support with genomic tools in breast cancer: a Scottish perspective. Breast, 75: 103728. ISSN 0960-9776

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Robertson, James
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Wood, Georgina
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Sarwar, Asma
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Bishr, Mai
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Webb, Rebekah
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Al-Zubaidi, Mohammed
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Eastlake, Leonie
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Lankester, Kate
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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McInerney, Samuel
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Creedon, Helen
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Stillie, Alison
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Purshouse, Karin
Author

Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin (2024) TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK. BMJ Open, 14 (12): e094838. ISSN 2044-6055

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Title:
TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK
Creators:
Mactier, Karen and Baxter, Mark and Peters, Adam and Fair, Katherine and Hannington, Laura and Robertson, James and Wood, Georgina and Sarwar, Asma and Bishr, Mai and Webb, Rebekah and Al-Zubaidi, Mohammed and Eastlake, Leonie and Lankester, Kate and McInerney, Samuel and Creedon, Helen and Stillie, Alison and Purshouse, Karin
Identification Number:
10.1136/bmjopen-2024-094838
Date:
December 2024
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:
BMJ Publishing Group
Additional Information:
KEM is currently a CRUK Scotland Institute-affiliated researcher at University of Glasgow (UoG) jointly funded by the Beatson and Edinburgh Cancer Centre Endowment Funds. ALLP is currently a UoG researcher funded by CRUK grant SEBCATP-2022/100004. KP is a researcher at the University of Edinburgh funded by Wellcome Trust grant 220399/Z/20/Z.
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https://pub.demo35.eprints-hosting.org/id/eprint/93
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
Date Deposited:
11 Jun 2025 16:34
Revision:
34
Last Modified:
12 Jun 2025 12:46
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