Hall-Younger, Ella and Tait, Stephen W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94: 102510. ISSN 0955-0674
AI Summary:
Mitochondria play a crucial role in regulating cell death, including apoptosis and other types of cell death. Mitochondrial outer membrane permeabilisation (MOMP) engages caspase activation and cell death.AI Topics:
Mitochondria are essential organelles in the life and death of a cell. During apoptosis, mitochondrial outer membrane permeabilisation (MOMP) engages caspase activation and cell death. Under nonlethal apoptotic stress, some mitochondria undergo permeabilisation, termed minority MOMP. Nonlethal apoptotic signalling impacts processes including genome stability, senescence and innate immunity. Recent studies have shown that upon MOMP, mitochondria and consequent signalling can trigger inflammation. We discuss how this occurs, and how mitochondrial inflammation might be targeted to increase tumour immunogenicity. Finally, we highlight how mitochondria contribute to other types of cell death including pyroptosis and ferroptosis. Collectively, these studies reveal critical new insights into how mitochondria regulate cell death, highlighting that mitochondrial signals engaged under nonlethal apoptotic stress have wide-ranging biological functions.
Hall-Younger, Ella
Author
Hall-Younger, Ella and Tait, Stephen W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94: 102510. ISSN 0955-0674
Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836
See full publications listTait, Stephen W.G.
Author
Hall-Younger, Ella and Tait, Stephen W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94: 102510. ISSN 0955-0674
Ahmed Hassan Elshiekh, Asma and Tait, Stephen W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18 (5). pp. 1054-1057. ISSN 1574-7891
Vringer, Esmee and Heilig, Rosalie and Riley, Joel S. and Black, Annabel and Cloix, Catherine and Skalka, George and Montes-Gómez, Alfredo E. and Aguado, Aurore and Lilla, Sergio and Walczak, Henning and Gyrd-Hansen, Mads and Murphy, Daniel J. and Huang, Danny T. and Zanivan, Sara and Tait, Stephen W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43 (6). pp. 904-930. ISSN 0261-4189
See full publications listAvailable under License Creative Commons Attribution.
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