Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

Abstract

Dialysis and kidney transplantation (Ktx) mitigate some of the physiological deficits in chronic kidney disease (CKD), but it remains to be determined if these mitigate microbial dysbiosis and the production of inflammatory microbial metabolites, which contribute significantly to the uraemic phenotype. We have investigated bacterial DNA signatures present in the circulation of CKD patients and those receiving a KTx. Our data are consistent with increasing dysbiosis as CKD progresses, with an accompanying increase in trimethylamine (TMA) producing pathobionts Pseudomonas and Bacillus. Notably, KTx patients displayed a significantly different microbiota compared to CKD5 patients, which surprisingly included further increase in TMA producing Bacillus and loss of salutogenic Lactobacilli. Only two genera (Viellonella and Saccharimonidales) showed significant differences in abundance following KTx that may reflect a reciprocal relationship between TMA producers and utilisers, which supersedes restoration of a normative microbiome. Our metadata analysis confirmed that TMA N-oxide along with one carbon metabolism, had significant impact upon both inflammatory burden and the composition of the microbiome. This indicates that these metabolites are key to shaping the uraemic microbiome and might be exploited in the development of dietary intervention strategies to both mitigate the physiological deficits in CKD and enable the restoration of a more salutogenic microbiome.

People
Craven, Hannah
Author

Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

See full publications list
Erlandsson, Helen
Author

Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

See full publications list
McGuinness, Dagmara
Author

Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

See full publications list
McGuinness, David
Author

Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

See full publications list
Mafra, Denise
Author

Mafra, Denise and Ugochukwu, Stephanie Ariemu and Borges, Natalia A and Cardozo, Ludmila F. M. F and Stenvinkel, Peter and Shiels, Paul G. (2024) Food for healthier aging: power on your plate. Critical Reviews in Food Science and Nutrition, 64 (3). pp. 603-616. ISSN 1040-8398

Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

See full publications list
Ijaz, Umer
Author

Cholet, Fabien and Vignola, Marta and Quinn, Dominic and Ijaz, Umer Z. and Sloan, William T. and Smith, Cindy J. (2025) Microbial ecology of drinking water biofiltration based on 16S rRNA sequencing: a meta-analysis. Water Research, 281: 123684. ISSN 0043-1354

Saleem, Farrukh and Ameer, Aqsa and Afzal, Farhan and Usman, Muhammad and Irshad, Hamid and Sattar, Sadia and Ijaz, Umer Zeeshan and Javed, Sundus (2025) A cross-sectional survey of poultry management systems, practices and antimicrobial use in relation to disease outbreak in Pakistan. BMC Research Notes, 18: 144. ISSN 1756-0500

Badar, Ayesha and Aqueel, Rhea and Nawaz, Ali and Ijaz, Umer Zeeshan and Malik, Kauser Abdulla (2025) Microbiota transplantation for Cotton Leaf Curl Disease suppression - core microbiome and transcriptome dynamics. Communications Biology, 8 (1): 380. ISSN 2399-3642

See full publications list
Bergman, Peter
Author

Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

See full publications list
Shiels, Paul G.
Author

Mafra, Denise and Ugochukwu, Stephanie Ariemu and Borges, Natalia A and Cardozo, Ludmila F. M. F and Stenvinkel, Peter and Shiels, Paul G. (2024) Food for healthier aging: power on your plate. Critical Reviews in Food Science and Nutrition, 64 (3). pp. 603-616. ISSN 1040-8398

Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

See full publications list
Stenvinkel, Peter
Author

Mafra, Denise and Ugochukwu, Stephanie Ariemu and Borges, Natalia A and Cardozo, Ludmila F. M. F and Stenvinkel, Peter and Shiels, Paul G. (2024) Food for healthier aging: power on your plate. Critical Reviews in Food Science and Nutrition, 64 (3). pp. 603-616. ISSN 1040-8398

Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137 (20). pp. 1563-1575. ISSN 0143-5221

See full publications list
Texts
483:501
lightbox image
307634.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview
Information
Title:
A normative microbiome is not restored following kidney transplantation
Creators:
Craven, Hannah and Erlandsson, Helen and McGuinness, Dagmara and McGuinness, David and Mafra, Denise and Ijaz, Umer Zeeshan and Bergman, Peter and Shiels, Paul G. and Stenvinkel, Peter
Identification Number:
10.1042/CS20230779
Date:
17 October 2023
Divisions:
College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
College of Science and Engineering > School of Engineering > Infrastructure and Environment
Publisher:
Portland Press
Additional Information:
Funding provided by Swedish Medical Research Council, CIMED and Heart and Lung Foundation.
Library
URI:
https://pub.demo35.eprints-hosting.org/id/eprint/483
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
Date Deposited:
11 Jun 2025 16:38
Revision:
29
Last Modified:
12 Jun 2025 09:33
View Item