Ramage, Gordon and Borghi, Elisa and Fortuna Rodrigues, Celia and Kean, Ryan and Williams, Craig and Lopez-Ribot, Jose (2023) Our current clinical understanding of Candida biofilms: where are we two decades on? APMIS: Journal of Pathology, Microbiology and Immunology, 131 (11). pp. 636-653. ISSN 0903-4641
AI Summary:
Candida biofilms have been clinically recognized for decades, although their formal designation emerged around 20 years ago. These biofilms are highly tolerant to antifungal therapies and can cause infections in various parts of the body.AI Topics:
Clinically we have been aware of the concept of Candida biofilms for many decades, though perhaps without the formal designation. Just over 20 years ago the subject emerged on the back of progress made from the bacterial biofilms, and academic progress pace has continued to mirror the bacterial biofilm community, albeit at a decreased volume. It is apparent that Candida species have a considerable capacity to colonize surfaces and interfaces and form tenacious biofilm structures, either alone or in mixed species communities. From the oral cavity, to the respiratory and genitourinary tracts, wounds, or in and around a plethora of biomedical devices, the scope of these infections is vast. These are highly tolerant to antifungal therapies that has a measurable impact on clinical management. This review aims to provide a comprehensive overight of our current clinical understanding of where these biofilms cause infections, and we discuss existing and emerging antifungal therapies and strategies.
Ramage, Gordon
Author
Allkja, Jontana and Bakri, Ahmed and Short, Bryn and Gilmour, Andrew and Brown, Jason L. and Bal, Abhijit M. and Newby, Kelly J.M. and Jenkins, Toby and Short, Rob D. and Williams, Craig and Ramage, Gordon (2025) Investigating the prevalence of fungi in diabetic ulcers: an under-recognised contributor to polymicrobial biofilms. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (4): e70025. ISSN 0903-4641
Ware, Alicia and Johnston, William and Delaney, Christopher and Butcher, Mark C. and Ramage, Gordon and Price, Lesley and Butcher, John and Kean, Ryan (2025) Dry surface biofilm formation by Candida auris facilitates persistence and tolerance to sodium hypochlorite. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (4): e70022. ISSN 0903-4641
Abduljalil, Hafsa and Alshanta, Om Alkhir and Chougule, Safa and Butcher, Mark and Short, Bryn and Mclean, William and Parry, Neil and O'Keeffe, Joanne and Ramage, Gordon (2025) Lactams exhibit potent antifungal activity against monospecies and multispecies interkingdom biofilms on a novel hydrogel skin model. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (1): e13510. ISSN 0903-4641
See full publications listBorghi, Elisa
Author
Ramage, Gordon and Borghi, Elisa and Fortuna Rodrigues, Celia and Kean, Ryan and Williams, Craig and Lopez-Ribot, Jose (2023) Our current clinical understanding of Candida biofilms: where are we two decades on? APMIS: Journal of Pathology, Microbiology and Immunology, 131 (11). pp. 636-653. ISSN 0903-4641
See full publications listFortuna Rodrigues, Celia
Author
Ramage, Gordon and Borghi, Elisa and Fortuna Rodrigues, Celia and Kean, Ryan and Williams, Craig and Lopez-Ribot, Jose (2023) Our current clinical understanding of Candida biofilms: where are we two decades on? APMIS: Journal of Pathology, Microbiology and Immunology, 131 (11). pp. 636-653. ISSN 0903-4641
See full publications listKean, Ryan
Author
Ware, Alicia and Johnston, William and Delaney, Christopher and Butcher, Mark C. and Ramage, Gordon and Price, Lesley and Butcher, John and Kean, Ryan (2025) Dry surface biofilm formation by Candida auris facilitates persistence and tolerance to sodium hypochlorite. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (4): e70022. ISSN 0903-4641
Ramage, Gordon and Borghi, Elisa and Fortuna Rodrigues, Celia and Kean, Ryan and Williams, Craig and Lopez-Ribot, Jose (2023) Our current clinical understanding of Candida biofilms: where are we two decades on? APMIS: Journal of Pathology, Microbiology and Immunology, 131 (11). pp. 636-653. ISSN 0903-4641
See full publications listWilliams, Craig
Author
Allkja, Jontana and Bakri, Ahmed and Short, Bryn and Gilmour, Andrew and Brown, Jason L. and Bal, Abhijit M. and Newby, Kelly J.M. and Jenkins, Toby and Short, Rob D. and Williams, Craig and Ramage, Gordon (2025) Investigating the prevalence of fungi in diabetic ulcers: an under-recognised contributor to polymicrobial biofilms. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (4): e70025. ISSN 0903-4641
Delaney, Christopher and Short, Bryn and Rajendran, Ranjith and Kean, Ryan and Burgess, Karl and Williams, Craig and Munro, Carol A. and Ramage, Gordon (2023) An integrated transcriptomic and metabolomic approach to investigate the heterogeneous Candida albicans biofilm phenotype. Biofilm, 5: 100112. ISSN 2590-2075
Ramage, Gordon and Borghi, Elisa and Fortuna Rodrigues, Celia and Kean, Ryan and Williams, Craig and Lopez-Ribot, Jose (2023) Our current clinical understanding of Candida biofilms: where are we two decades on? APMIS: Journal of Pathology, Microbiology and Immunology, 131 (11). pp. 636-653. ISSN 0903-4641
See full publications listLopez-Ribot, Jose
Author
Ramage, Gordon and Borghi, Elisa and Fortuna Rodrigues, Celia and Kean, Ryan and Williams, Craig and Lopez-Ribot, Jose (2023) Our current clinical understanding of Candida biofilms: where are we two decades on? APMIS: Journal of Pathology, Microbiology and Immunology, 131 (11). pp. 636-653. ISSN 0903-4641
See full publications listAvailable under License Creative Commons Attribution.
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