Lappin, David Francis and Thomas, Sheeba and Bennett, David and Nile, Christopher and Riggio, Marcello Pasquale (2024) Elevated pro-inflammatory cytokines and chemokines in saliva of cats with feline odontoclastic resorptive lesion. Research in Veterinary Science, 166: 105092. ISSN 0034-5288
AI Summary:
Feline odontoclastic resorptive lesion (FORL) is an inflammatory oral disease of unknown etiopathogenesis. The study aimed to investigate the levels of immune-associated molecules in saliva of healthy and diseased cats.AI Topics:
Feline odontoclastic resorptive lesion (FORL) is an inflammatory oral disease of unknown aetiopathogenesis that affects between 20% to 75% of cats. Twenty immune-associated molecules were measured in saliva of 25 healthy and 40 cats with FORL using a multiplex assay. No statistically significant differences were observed in the levels of these proteins between the healthy group and the diseased group of cats. A two-step cluster analysis of the oral microbiome and salivary cytokine data identified two subgroups of cats with FORL: FORL-1 (subset of cats with a less diverse oral microbiome) and FORL-2 (diseased cats with a microbiome similar to that of healthy animals). The level of some key proinflammatory cytokines (IL-1β, IL-12p40) and chemokines (IL-8, RANTES, KC) were significantly higher in the FORL-1 subgroup than in the FORL-2 subgroup and the healthy group. In addition, TNF-α levels were greater in the FORL-1 subgroup than in the FORL-2 subgroup. These increases in pro-inflammatory cytokines and chemokines indicate active ongoing inflammation that may promote the osteoclastic/odontoclastic activity associated with FORL.
Lappin, David Francis
Author
Lappin, David Francis and Thomas, Sheeba and Bennett, David and Nile, Christopher and Riggio, Marcello Pasquale (2024) Elevated pro-inflammatory cytokines and chemokines in saliva of cats with feline odontoclastic resorptive lesion. Research in Veterinary Science, 166: 105092. ISSN 0034-5288
See full publications listThomas, Sheeba
Author
Lappin, David Francis and Thomas, Sheeba and Bennett, David and Nile, Christopher and Riggio, Marcello Pasquale (2024) Elevated pro-inflammatory cytokines and chemokines in saliva of cats with feline odontoclastic resorptive lesion. Research in Veterinary Science, 166: 105092. ISSN 0034-5288
See full publications listBennett, David
Author
Lappin, David Francis and Thomas, Sheeba and Bennett, David and Nile, Christopher and Riggio, Marcello Pasquale (2024) Elevated pro-inflammatory cytokines and chemokines in saliva of cats with feline odontoclastic resorptive lesion. Research in Veterinary Science, 166: 105092. ISSN 0034-5288
See full publications listNile, Christopher
Author
Lappin, David Francis and Thomas, Sheeba and Bennett, David and Nile, Christopher and Riggio, Marcello Pasquale (2024) Elevated pro-inflammatory cytokines and chemokines in saliva of cats with feline odontoclastic resorptive lesion. Research in Veterinary Science, 166: 105092. ISSN 0034-5288
See full publications listRiggio, Marcello
Author
Lappin, David Francis and Thomas, Sheeba and Bennett, David and Nile, Christopher and Riggio, Marcello Pasquale (2024) Elevated pro-inflammatory cytokines and chemokines in saliva of cats with feline odontoclastic resorptive lesion. Research in Veterinary Science, 166: 105092. ISSN 0034-5288
Baz, Abdullah and Bakri, Ahmed and Butcher, Mark and Short, Bryn and Ghimire, Bhagirath and Gaur, Nishtha and Jenkins, Toby and Short, Robert D. and Riggio, Marcello and Williams, Craig and Ramage, Gordon and Brown, Jason L. (2023) Staphylococcus aureus strains exhibit heterogenous tolerance to direct cold atmospheric plasma therapy. Biofilm, 5: 100123. ISSN 2590-2075
See full publications listAvailable under License Creative Commons Attribution.
Download (762kB) | Preview
 |