Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
AI Summary:
The study investigated the relationship between flow-metabolic phenotype and overall survival of pancreatic ductal adenocarcinoma (PDAC). The results showed that hypoattenuating PDAC with high 18F-FDG uptake had the poorest prognosis, while iso- or hyperattenuating PDAC with low 18F-FDG uptake had a better prognosis.AI Topics:
Background
Retrospective analysis to investigate the relationship between the flow-metabolic phenotype and overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) and its potential clinical utility.
Methods
Patients with histopathologically proven PDAC between 2005 and 2014 using tumor attenuation on routine pre-operative CECT as a surrogate for the vascularity and [18F]FDG-uptake as a surrogate for metabolic activity on [18F]FDG-PET.
Results
In total, 93 patients (50 male, 43 female, median age 63) were included. Hypoattenuating PDAC with high [18F]FDG-uptake has the poorest prognosis (median OS 7 ± 1 months), compared to hypoattenuating PDAC with low [18F]FDG-uptake (median OS 11 ± 3 months; p = 0.176), iso- or hyperattenuating PDAC with high [18F]FDG-uptake (median OS 15 ± 5 months; p = 0.004) and iso- or hyperattenuating PDAC with low [18F]FDG-uptake (median OS 23 ± 4 months; p = 0.035). In multivariate analysis, surgery combined with tumor differentiation, tumor stage, systemic therapy and flow metabolic phenotype remained independent predictors for overall survival.
Discussion
The novel qualitative flow-metabolic phenotype of PDAC using a combination of CECT and [18F]FDG-PET features, predicted significantly worse survival for hypoattenuating-high uptake pancreatic cancers compared to the other phenotypes.
Riviere, Deniece
Author
Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
See full publications listAarntzen, Erik
Author
Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
See full publications listvan Geenen, Erwin
Author
Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
See full publications listChang, David
Author
Cooke, Sean F. and Wright, Thomas A. and Sin, Yuan Yan and Ling, Jiayue and Kyurkchieva, Elka and Phanthaphol, Nattaporn and McSkimming, Thomas and Herbert, Katharine and Rebus, Selma and Biankin, Andrew V. and Chang, David K. and Baillie, George S. and Blair, Connor M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14: 8998. ISSN 2045-2322
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Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966
See full publications listde Geus-Oei, Lioe-Fee
Author
Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
See full publications listBrosens, Lodewijk
Author
Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
See full publications listvan Laarhoven, Kees
Author
Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
See full publications listGotthardt, Martin
Author
Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
See full publications listHermans, John
Author
Riviere, Deniece and Aarntzen, Erik and van Geenen, Erwin and Chang, David and de Geus-Oei, Lioe-Fee and Brosens, Lodewijk and van Laarhoven, Kees and Gotthardt, Martin and Hermans, John (2024) Qualitative flow metabolic phenotype of pancreatic cancer: a new prognostic biomarker? HPB, 26 (3). pp. 389-399. ISSN 1365-182X
See full publications listAvailable under License Creative Commons Attribution Non-commercial No Derivatives.
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