Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

Abstract

Pancreatic cancer is a malignant tumor of the digestive system. It is highly aggressive, easily metastasizes, and extremely difficult to treat. This study aimed to analyze the genes that might regulate pancreatic cancer migration to provide an essential basis for the prognostic assessment of pancreatic cancer and individualized treatment. A CRISPR knockout library directed against 915 murine genes was transfected into TB 32047 cell line to screen which gene loss promoted cell migration. Next-generation sequencing and PinAPL.py- analysis was performed to identify candidate genes. We then assessed the effect of serine/threonine kinase 11 (STK11) knockout on pancreatic cancer by wound-healing assay, chick agnosia (CAM) assay, and orthotopic mouse pancreatic cancer model. We performed RNA sequence and Western blotting for mechanistic studies to identify and verify the pathways. After accelerated Transwell migration screening, STK11 was identified as one of the top candidate genes. Further experiments showed that targeted knockout of STK11 promoted the cell migration and increased liver metastasis in mice. Mechanistic analyses revealed that STK11 knockout influences blood vessel morphogenesis and is closely associated with the enhanced expression of phosphodiesterases (PDEs), especially PDE4D, PDE4B, and PDE10A. PDE4 inhibitor Roflumilast inhibited STK11-KO cell migration and tumor size, further demonstrating that PDEs are essential for STK11-deficient cell migration. Our findings support the adoption of therapeutic strategies, including Roflumilast, for patients with STK11-mutated pancreatic cancer in order to improve treatment efficacy and ultimately prolong survival.

People

Zhang, Shuman

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Yun, Duo

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Yang, Hao

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Eckstein, Markus

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Elbait, Gihan Daw

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Zhou, Yaxing

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Lu, Yanxi

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Yang, Hai

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Zhang, Jinping

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Dörflein, Isabella

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Britzen-Laurent, Nathalie

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Pfeffer, Susanne

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Stemmler, Marc P.

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Dahl, Andreas

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Mukhopadhyay, Debabrata

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Chang, David

Author

Cooke, Sean F. and Wright, Thomas A. and Sin, Yuan Yan and Ling, Jiayue and Kyurkchieva, Elka and Phanthaphol, Nattaporn and McSkimming, Thomas and Herbert, Katharine and Rebus, Selma and Biankin, Andrew V. and Chang, David K. and Baillie, George S. and Blair, Connor M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14: 8998. ISSN 2045-2322

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966

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He, Hang

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Zeng, Siyuan

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Lan, Bin

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Frey, Benjamin

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Hampel, Chuanpit

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Lentsch, Eva

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Gollavilli, Paradesi Naidu

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Büttner, Christian

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Ekici, Arif B

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Biankin, Andrew

Author

Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235

Cooke, Sean F. and Wright, Thomas A. and Sin, Yuan Yan and Ling, Jiayue and Kyurkchieva, Elka and Phanthaphol, Nattaporn and McSkimming, Thomas and Herbert, Katharine and Rebus, Selma and Biankin, Andrew V. and Chang, David K. and Baillie, George S. and Blair, Connor M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14: 8998. ISSN 2045-2322

Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723

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Schneider-Stock, Regine

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Ceppi, Paolo

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

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Grützmann, Robert

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

See full publications list

Pilarsky, Christian

Author

Zhang, Shuman and Yun, Duo and Yang, Hao and Eckstein, Markus and Elbait, Gihan Daw and Zhou, Yaxing and Lu, Yanxi and Yang, Hai and Zhang, Jinping and Dörflein, Isabella and Britzen-Laurent, Nathalie and Pfeffer, Susanne and Stemmler, Marc P. and Dahl, Andreas and Mukhopadhyay, Debabrata and Chang, David and He, Hang and Zeng, Siyuan and Lan, Bin and Frey, Benjamin and Hampel, Chuanpit and Lentsch, Eva and Gollavilli, Paradesi Naidu and Büttner, Christian and Ekici, Arif B and Biankin, Andrew and Schneider-Stock, Regine and Ceppi, Paolo and Grützmann, Robert and Pilarsky, Christian (2024) Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Cell Death Discovery, 10: 124. ISSN 2058-7716

See full publications list
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