Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

Abstract

Approved therapies for the treatment of patients with pulmonary arterial hypertension (PAH) mediate pulmonary vascular vasodilatation by targeting distinct biological pathways. International guidelines recommend that patients with an inadequate response to dual therapy with a phosphodiesterase type‐5 inhibitor (PDE5i) and endothelin receptor antagonist (ERA), are recommended to either intensify oral therapy by adding a selective prostacyclin receptor (IP) agonist (selexipag), or switching from PDE5i to a soluble guanylate‐cyclase stimulator (sGCS; riociguat). The clinical equipoise between these therapeutic choices provides the opportunity for evaluation of individualized therapeutic effects. Traditionally, invasive/hospital‐based investigations are required to comprehensively assess disease severity and demonstrate treatment benefits. Regulatory‐approved, minimally invasive monitors enable equivalent measurements to be obtained while patients are at home. In this 2 × 2 randomized crossover trial, patients with PAH established on guideline‐recommended dual therapy and implanted with CardioMEMS™ (a wireless pulmonary artery sensor) and ConfirmRx™ (an insertable cardiac rhythm monitor), will receive ERA + sGCS, or PDEi + ERA + IP agonist. The study will evaluate clinical efficacy via established clinical investigations and remote monitoring technologies, with remote data relayed through regulatory‐approved online clinical portals. The primary aim will be the change in right ventricular systolic volume measured by magnetic resonance imaging (MRI) from baseline to maximal tolerated dose with each therapy. Using data from MRI and other outcomes, including hemodynamics, physical activity, physiological measurements, quality of life, and side effect reporting, we will determine whether remote technology facilitates early evaluation of clinical efficacy, and investigate intra‐patient efficacy of the two treatment approaches.

People
Varian, Frances
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Dick, Jennifer
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Battersby, Christian
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Roman, Stefan
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Ablott, Jenna
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Watson, Lisa
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Binmahfooz, Sarah
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Zafar, Hamza
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Colgan, Gerry
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Cannon, John
Author

Stubbs, Harrison and Cannon, John and Knightbridge, Emily and Durrington, Charlotte and Roddis, Chloe and Gin-Sing, Wendy and Massey, Fiona and Knight, Daniel S. and Virsinskaite, Ruta and Lordan, James L. and Sear, Eleanoe and Apple-Pinguel, Joy and Morris, Eleanor and Johnson, Martin K. and Wort, Stephen J. (2024) Sendaway capillary NT-proBNP in pulmonary hypertension. BMJ Open Respiratory Research, 11 (1): e002124. ISSN 2052-4439

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Suntharalingam, Jay
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Lordan, Jim
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Howard, Luke
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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McCabe, Colm
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Wort, John
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Price, Laura
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Church, Colin
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Hamilton, Neil
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Armstrong, Iain
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Hameed, Abdul
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Hurdman, Judith
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Elliot, Charlie
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Condliffe, Robin
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Wilkins, Martin
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Webb, Alastair
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Adlam, David
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Benza, Ray L.
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Rahimi, Kazem
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Shojaei‐Shahrokhabadi, Mohadeseh
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Lin, Nan X.
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Wason, James M. S.
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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McIntosh, Alasdair
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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McConnachie, Alex
Author

Taylor, Rod and Burrell, Emma and O’Hare, Claire and Thomson, Elizabeth and Placzek, Anna and Bollen, Jessica and Cleland, John G.F. and Cowie, Ansley and Dalal, Hasnain and Deaton, Christi and Doherty, Patrick and Dudman, Katie and Fraser, Heather and Frost, Julia and Greaves, Colin J. and Hartshorne-Evans, Nick and Hillsdon, Melvyn and Ibbotson, Tracy and Jarallah, Mohammad and Jolly, Kate and McConnachie, Alex and McIntosh, Emma and Smith, Valerie and Squire, Iain and Taylor, Louise and van Beurden, Sam and Lang, Chim C. and REACH-HFpEF investigators (2025) Clinical effectiveness and cost-effectiveness of the rehabilitation enablement in chronic heart failure facilitated self-care rehabilitation intervention for people with heart failure with preserved ejection fraction and their caregivers: rationale and protocol for a multicentre randomised controlled trial – REACH-HFpEF trial. BMJ Open, 15 (5): e094254. ISSN 2044-6055

Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422

Dagnan, Dave and Thompson, Paul and Hastings, Richard P. and Hatton, Chris and Melville, Craig and Cooper, Sally-Ann and McMeekin, Nicola and Fulton, Lauren and Jones, Rob S.P. and McConnachie, Alex and Jahoda, Andrew (2024) The influence of therapy quality on outcomes from behavioural activation and guided self-help treatments for depression in adults with intellectual disabilities. British Journal of Clinical Psychology, 64 (2). pp. 139-147. ISSN 0144-6657

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Middleton, Jennifer T.
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Thompson, Roger
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Kiely, David G.
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Toshner, Mark
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Rothman, Alexander
Author

Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander (2024) Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies. Pulmonary Circulation, 14 (1): e12337. ISSN 2045-8932

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Title:
Pulmonary hypertension: intensification and personalization of combination Rx (PHoenix): a phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies
Creators:
Varian, Frances and Dick, Jennifer and Battersby, Christian and Roman, Stefan and Ablott, Jenna and Watson, Lisa and Binmahfooz, Sarah and Zafar, Hamza and Colgan, Gerry and Cannon, John and Suntharalingam, Jay and Lordan, Jim and Howard, Luke and McCabe, Colm and Wort, John and Price, Laura and Church, Colin and Hamilton, Neil and Armstrong, Iain and Hameed, Abdul and Hurdman, Judith and Elliot, Charlie and Condliffe, Robin and Wilkins, Martin and Webb, Alastair and Adlam, David and Benza, Ray L. and Rahimi, Kazem and Shojaei‐Shahrokhabadi, Mohadeseh and Lin, Nan X. and Wason, James M. S. and McIntosh, Alasdair and McConnachie, Alex and Middleton, Jennifer T. and Thompson, Roger and Kiely, David G. and Toshner, Mark and Rothman, Alexander
Identification Number:
10.1002/pul2.12337
Date:
17 March 2024
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
Publisher:
Wiley
Additional Information:
Funding information MRC Experimental Medicine Project, Grant/Award Number: MR/W026279/1;Wellcome Trust Clinical Research Career Development Fellowship, Grant/Award Numbers: 206632/Z/17/Z,205188/Z/16/Z, 214567/Z/18/Z; BHF Intermediate Fellowship, Grant/Award Number: FS/18/13/33281;National Institute for Health Research, Grant/Award Number: NIHR301614.
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URI:
https://pub.demo35.eprints-hosting.org/id/eprint/329
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
SWORD Depositor:
Users 37347 not found.
Date Deposited:
11 Jun 2025 16:37
Revision:
12
Last Modified:
12 Jun 2025 10:21
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