Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
AI Summary:
UNSPECIFIEDAI Topics:
Background:
Tenecteplase has potential benefits over alteplase, the standard agent for intravenous thrombolysis in acute ischaemic stroke, because it is administered as a single bolus and might have superior efficacy. The ATTEST-2 trial investigated whether tenecteplase was non-inferior or superior to alteplase within 4·5 h of onset.
Methods:
We undertook a prospective, randomised, parallel-group, open-label trial with masked endpoint evaluation in 39 UK stroke centres. Previously independent adults with acute ischaemic stroke, eligible for intravenous thrombolysis less than 4·5 h from last known well, were randomly assigned 1:1 to receive intravenous alteplase 0·9 mg/kg or tenecteplase 0·25 mg/kg, by use of a telephone-based interactive voice response system. The primary endpoint was the distribution of the day 90 modified Rankin Scale (mRS) score and was analysed using ordinal logistic regression in the modified intention-to-treat population. We tested the primary outcome for non-inferiority (odds ratio for tenecteplase vs alteplase non-inferiority limit of 0·75), and for superiority if non-inferiority was confirmed. Safety outcomes were mortality, symptomatic intracranial haemorrhage, radiological intracranial haemorrhage, and major extracranial bleeding. The trial was prospectively registered on ClinicalTrials.gov (NCT02814409).
Findings:
Between Jan 25, 2017, and May 30, 2023, 1858 patients were randomly assigned to a treatment group, of whom 1777 received thrombolytic treatment and were included in the modified intention-to-treat population (n=885 allocated tenecteplase and n=892 allocated alteplase). The mean age of participants was 70·4 (SD 12·9) years and median National Institutes of Health Stroke Scale was 7 (IQR 5–13) at baseline. Tenecteplase was non-inferior to alteplase for mRS score distribution at 90 days, but was not superior (odds ratio 1·07; 95% CI 0·90–1·27; p value for non-inferiority<0·0001; p=0·43 for superiority). 68 (8%) patients in the tenecteplase group compared with 75 (8%) patients in the alteplase group died, symptomatic intracerebral haemorrhage (defined by SITS-MOST criteria) occurred in 20 (2%) versus 15 (2%) patients, parenchymal haematoma type 2 occurred in 37 (4%) versus 26 (3%) patients, post-treatment intracranial bleed occurred in 94 (11%) versus 78 (9%) patients, significant extracranial haemorrhage occurred in 13 (1%) versus six (1%) patients, respectively, and angioedema occurred in six (1%) participants in both groups.
Interpretation:
Tenecteplase 0·25 mg/kg was non-inferior to 0·9 mg/kg alteplase within 4·5 h of symptom onset in acute ischaemic stroke. Easier administration of tenecteplase, especially in the context of interhospital transfers, indicates that tenecteplase should be preferred to alteplase for thrombolysis in acute ischaemic stroke. The ATTEST-2 population was large and representative of thrombolysis-eligible patients in the UK and, together with findings from other trials, provides robust evidence supporting the introduction of tenecteplase in preference to alteplase.
Muir, Keith
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listFord, Gary A.
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listFord, Ian
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
Cleland, John and Pellicori, Pierpaolo and Graham, Fraser J. and Lane, Rebecca and Petrie, Mark C. and Ahmed, Fozia and Squire, Iain B. and Ludman, Andrew and Japp, Alan and Al-Mohammad, Abdallah and Clark, Andrew L. and Szwejkowski, Ben and Critoph, Chris and Chong, Victor and Schiff, Rebekah and Nageh, Thuraia and Glover, Jason and McMurray, John J.V. and Thomson, Elizabeth A. and Robertson, Michele and Ford, Ian and Kalra, Philip A. and Kalra, Paul R. (2024) Adjudication of hospitalizations and deaths in the IRONMAN Trial of intravenous iron for heart failure. Journal of the American College of Cardiology, 84 (18). pp. 1704-1717. ISSN 0735-1097
See full publications listWardlaw, Joanna M.
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listMcConnachie, Alex
Author
Taylor, Rod and Burrell, Emma and O’Hare, Claire and Thomson, Elizabeth and Placzek, Anna and Bollen, Jessica and Cleland, John G.F. and Cowie, Ansley and Dalal, Hasnain and Deaton, Christi and Doherty, Patrick and Dudman, Katie and Fraser, Heather and Frost, Julia and Greaves, Colin J. and Hartshorne-Evans, Nick and Hillsdon, Melvyn and Ibbotson, Tracy and Jarallah, Mohammad and Jolly, Kate and McConnachie, Alex and McIntosh, Emma and Smith, Valerie and Squire, Iain and Taylor, Louise and van Beurden, Sam and Lang, Chim C. and REACH-HFpEF investigators (2025) Clinical effectiveness and cost-effectiveness of the rehabilitation enablement in chronic heart failure facilitated self-care rehabilitation intervention for people with heart failure with preserved ejection fraction and their caregivers: rationale and protocol for a multicentre randomised controlled trial – REACH-HFpEF trial. BMJ Open, 15 (5): e094254. ISSN 2044-6055
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
Dagnan, Dave and Thompson, Paul and Hastings, Richard P. and Hatton, Chris and Melville, Craig and Cooper, Sally-Ann and McMeekin, Nicola and Fulton, Lauren and Jones, Rob S.P. and McConnachie, Alex and Jahoda, Andrew (2024) The influence of therapy quality on outcomes from behavioural activation and guided self-help treatments for depression in adults with intellectual disabilities. British Journal of Clinical Psychology, 64 (2). pp. 139-147. ISSN 0144-6657
See full publications listGreenlaw, Nicola
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listMair, Grant
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listSprigg, Nikola
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listPrice, Christopher I.
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listMacLeod, Mary Joan
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listDima, Sofia
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listVenter, Marius
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listZhang, Liqun
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listO’Brien, Eoin
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listSanyal, Ranjan
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listReid, John
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listSztriha, Laszlo K.
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listHaider, Syed
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listWhiteley, William N.
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listKennedy, James
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listPerry, Richard
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listMarigold, Richard
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listRaghunathan, Senthil
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listSims, Don
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listBhandari, Mohit
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listWiggam, Ivan
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listRashed, Khalid
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listDouglass, Chris
Author
Muir, Keith and Ford, Gary A. and Ford, Ian and Wardlaw, Joanna M. and McConnachie, Alex and Greenlaw, Nicola and Mair, Grant and Sprigg, Nikola and Price, Christopher I. and MacLeod, Mary Joan and Dima, Sofia and Venter, Marius and Zhang, Liqun and O’Brien, Eoin and Sanyal, Ranjan and Reid, John and Sztriha, Laszlo K. and Haider, Syed and Whiteley, William N. and Kennedy, James and Perry, Richard and Marigold, Richard and Raghunathan, Senthil and Sims, Don and Bhandari, Mohit and Wiggam, Ivan and Rashed, Khalid and Douglass, Chris (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23 (11). pp. 1087-1096. ISSN 1474-4422
See full publications listAvailable under License Creative Commons Attribution.
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