Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
AI Summary:
A novel impedimetric sensing platform was developed to detect urinary zinc (UZn) in artificial and clinical urine samples. The sensor demonstrated a limit of detection of 7.33 ng/mL, comparable with results from inductively coupled plasma mass spectrometry (ICP-MS).AI Topics:
With the global escalation of concerns surrounding prostate cancer (PCa) diagnosis, reliance on the serologic prostate-specific antigen (PSA) test remains the primary approach. However, the imperative for early PCa diagnosis necessitates more effective, accurate, and rapid diagnostic point-of-care (POC) devices to enhance the result reliability and minimize disease-related complications. Among POC approaches, electrochemical biosensors, known for their amenability and miniaturization capabilities, have emerged as promising candidates. In this study, we developed an impedimetric sensing platform to detect urinary zinc (UZn) in both artificial and clinical urine samples. Our approach lies in integrating label-free impedimetric sensing and the introduction of porosity through surface modification techniques. Leveraging a cellulose acetate/reduced graphene oxide composite, our sensor’s recognition layer is engineered to exhibit enhanced porosity, critical for improving the sensitivity, capture, and interaction with UZn. The sensitivity is further amplified by incorporating zincon as an external dopant, establishing highly effective recognition sites. Our sensor demonstrates a limit of detection of 7.33 ng/mL in the 0.1–1000 ng/mL dynamic range, which aligns with the reference benchmark samples from clinical biochemistry. Our sensor results are comparable with the results of inductively coupled plasma mass spectrometry (ICP-MS) where a notable correlation of 0.991 is achieved. To validate our sensor in a real-life scenario, tests were performed on human urine samples from patients being investigated for prostate cancer. Testing clinical urine samples using our sensing platform and ICP-MS produced highly comparable results. A linear correlation with R2 = 0.964 with no significant difference between two groups (p-value = 0.936) was found, thus confirming the reliability of our sensing platform.
Dehghani, Parisa
Author
Dehghani, Parisa and Salehirozveh, Mostafa and Tajabadi, Ataollah and Yeung, Chi Chung and Lam, Michael and Leung, Hing Y. and Roy, Vellaisamy A.L. (2025) Next-gen point-of-care tool for ultra-sensitive detection of urinary spermine for prostate cancer diagnosis. ACS Sensors, 10 (4). pp. 2640-2651. ISSN 2379-3694
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listKarthikeyan, Vaithinathan
Author
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listTajabadi, Ataollah
Author
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listAssi, Dani S.
Author
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listCatchpole, Anthony
Author
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listWadsworth, John
Author
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listLeung, Hing Y.
Author
Dehghani, Parisa and Salehirozveh, Mostafa and Tajabadi, Ataollah and Yeung, Chi Chung and Lam, Michael and Leung, Hing Y. and Roy, Vellaisamy A.L. (2025) Next-gen point-of-care tool for ultra-sensitive detection of urinary spermine for prostate cancer diagnosis. ACS Sensors, 10 (4). pp. 2640-2651. ISSN 2379-3694
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listRoy, Vellaisamy A.L.
Author
Dehghani, Parisa and Salehirozveh, Mostafa and Tajabadi, Ataollah and Yeung, Chi Chung and Lam, Michael and Leung, Hing Y. and Roy, Vellaisamy A.L. (2025) Next-gen point-of-care tool for ultra-sensitive detection of urinary spermine for prostate cancer diagnosis. ACS Sensors, 10 (4). pp. 2640-2651. ISSN 2379-3694
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listAvailable under License Creative Commons Attribution.
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