Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
AI Summary:
Enteral nutrition (EN) was found to have a dose-dependent impact on the faecal microbiota and diet-related bacterial metabolites. The study suggests that EN may detrimentally influence the gut microbiome, particularly at doses of at least 50%.AI Topics:
Introduction:
Enteral nutrition (EN) involves replacing all or part of a person's habitual diet with a nutritional formula. The impact of varying doses of EN on the gut microbiome remains understudied.
Methods:
Healthy adults replaced all (100% EN) or part (85% EN, 50% EN and 20% EN) of their energy requirements with EN for 7 days. Faecal samples were collected before and on day 7 of interventions. Faecal pH, short chain fatty acids (SCFAs), branched-chain fatty acids (BCFAs) and 16S rRNA sequencing were performed. Dietary assessment was performed with 7-day food diaries.
Results:
Sixty-one participants (31 females; median (IQR) age: 24.7 (23.0–27.8) years) were recruited. A dose-dependent impact of EN on faecal microbiota, SCFAs, BCFAs) and pH was observed, with changes detectable at EN intakes of at least 50% of energy requirements. 100% and 85% EN reduced the abundance of fibre-fermenting taxa such as Agathobacter, Faecalibaterium, Succinivibrio and Acidaminococcus. In parallel, potentially harmful organisms like Eubacterium, Actinomyces, and Klebsiella increased. In the 50% EN group, adherence to a diet high in fish, vegetables, potatoes, non-alcoholic beverages, and fat spreads, and low in cereal products, milk, and meat negatively correlated with changes in microbiota structure (r = −0.75, P = 0.025). This signal was not observed when using compositional tools for microbiota analysis.
Conclusions:
EN detrimentally influences the faecal microbiota and diet-related bacterial metabolites in a dose-dependent manner, particularly at doses of at least 50%. The findings of this study have implications for the dietary management and counselling of patients receiving high volume EN.
Jatkowska, Aleksandra
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
See full publications listGkikas, Konstantinos
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
Nichols, Ben and Briola, Anny and Logan, Michael and Havlik, Jaroslav and Mascellani, Anna and Gkikas, Konstantinos and Milling, Simon and Ijaz, Umer Zeeshan and Quince, Christopher and Svolos, Vaios and Russell, Richard K. and Hansen, Richard and Gerasimidis, Konstantinos (2024) Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn’s disease. American Journal of Clinical Nutrition, 119 (4). pp. 885-895. ISSN 0002-9165
See full publications listNichols, Ben
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
Nichols, Ben and Briola, Anny and Logan, Michael and Havlik, Jaroslav and Mascellani, Anna and Gkikas, Konstantinos and Milling, Simon and Ijaz, Umer Zeeshan and Quince, Christopher and Svolos, Vaios and Russell, Richard K. and Hansen, Richard and Gerasimidis, Konstantinos (2024) Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn’s disease. American Journal of Clinical Nutrition, 119 (4). pp. 885-895. ISSN 0002-9165
See full publications listShort, Bryn
Author
Allkja, Jontana and Bakri, Ahmed and Short, Bryn and Gilmour, Andrew and Brown, Jason L. and Bal, Abhijit M. and Newby, Kelly J.M. and Jenkins, Toby and Short, Rob D. and Williams, Craig and Ramage, Gordon (2025) Investigating the prevalence of fungi in diabetic ulcers: an under-recognised contributor to polymicrobial biofilms. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (4): e70025. ISSN 0903-4641
Abduljalil, Hafsa and Alshanta, Om Alkhir and Chougule, Safa and Butcher, Mark and Short, Bryn and Mclean, William and Parry, Neil and O'Keeffe, Joanne and Ramage, Gordon (2025) Lactams exhibit potent antifungal activity against monospecies and multispecies interkingdom biofilms on a novel hydrogel skin model. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (1): e13510. ISSN 0903-4641
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
See full publications listRizou, Vasiliki-Konstantina
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
See full publications listKapranos, Panagiotis
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
See full publications listKlein Gunnewiek, Jennier
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
See full publications listChristina, Edelyn
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
See full publications listSvolos, Vaios
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
Nichols, Ben and Briola, Anny and Logan, Michael and Havlik, Jaroslav and Mascellani, Anna and Gkikas, Konstantinos and Milling, Simon and Ijaz, Umer Zeeshan and Quince, Christopher and Svolos, Vaios and Russell, Richard K. and Hansen, Richard and Gerasimidis, Konstantinos (2024) Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn’s disease. American Journal of Clinical Nutrition, 119 (4). pp. 885-895. ISSN 0002-9165
See full publications listQuince, Christopher
Author
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
Nichols, Ben and Briola, Anny and Logan, Michael and Havlik, Jaroslav and Mascellani, Anna and Gkikas, Konstantinos and Milling, Simon and Ijaz, Umer Zeeshan and Quince, Christopher and Svolos, Vaios and Russell, Richard K. and Hansen, Richard and Gerasimidis, Konstantinos (2024) Gut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn’s disease. American Journal of Clinical Nutrition, 119 (4). pp. 885-895. ISSN 0002-9165
See full publications listGerasimidis, Konstantinos
Author
Bibi, Sara and Kerbiriou, Caroline and Uzma and Mckirdy, Shona and Kostrytsia, Anastasiia and Rasheed, Hifza and Eqani, Syed Ali Musstjab Akber Shah and Gerasimidis, Konstantinos and Nurulain, Syed Muhammad and Ijaz, Umer Zeeshan (2024) Gut microbiome and function are altered for individuals living in high fluoride concentration areas in Pakistan. Ecotoxicology and Environmental Safety, 284: 116959. ISSN 0147-6513
Koci, Orges and Russell, Richard K. and Shaikh, M. Guftar and Edwards, Christine and Gerasimidis, Konstantinos and Ijaz, Umer Zeeshan (2024) CViewer: a Java-based statistical framework for integration of shotgun metagenomics with other omics datasets. Microbiome, 12 (1): 117. ISSN 2049-2618
Jatkowska, Aleksandra and Gkikas, Konstantinos and Nichols, Ben and Short, Bryn and Rizou, Vasiliki-Konstantina and Kapranos, Panagiotis and Klein Gunnewiek, Jennier and Christina, Edelyn and Svolos, Vaios and Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
See full publications listAvailable under License Creative Commons Attribution.
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