Although the mechanical response of granular materials strongly depends on the interplay between their anisotropic internal structure (fabric) and loading direction, such coupling is not explicitly considered in existing high-cycle experimental datasets and models. High-cycle experiments on granular specimens specifically prepared with various fabric orientations are presented. It is found that the high-cycle strain accumulation behavior can change remarkably, from shakedown to ratcheting, when the fabric orientation deviates more from the loading direction. Inspired by the experimental observations, a fabric-dependent anisotropic high-cycle model is proposed, by proper recasting of an existing model formulated within Critical State Theory, into the framework of Anisotropic Critical State Theory. The model explicitly accounts for the fabric evolution, which is linked to plastic modulus, dilatancy and kinematic hardening rules. The model can quantitatively reproduce the high-cycle strain accumulation (i.e., shakedown and ratcheting) under drained conditions, as well as pre-liquefaction and post-liquefaction responses granular materials having widely ranged fabric anisotropy, densities and cyclic loading types using a unified set of constants. It exhibits a unique feature of simulating the distinct high-cycle strain accumulation and liquefaction of granular material with various fabric anisotropy, while the existing high-cycle models treat them equally. The successful reproduction of the anisotropic sand element response under high-cycle drained and undrained conditions makes it possible to perform whole life analysis of various foundations on granular soil subjected to high-cycle loading events.