De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
AI Summary:
The study reveals that CLDN18, a membrane tetraspanin, plays an immune role in orchestrating T-cell infiltration and shaping the tumor immune contexture.AI Topics:
Tumors weakly infiltrated by T lymphocytes poorly respond to immunotherapy. We aimed to unveil malignancy-associated programs regulating T cell entrance, arrest, and activation in the tumor environment. Differential expression of cell adhesion and tissue architecture programs, particularly the presence of the membrane tetraspanin claudin (CLDN)18 as a signature gene, demarcated immune-infiltrated from immune-depleted mouse pancreatic tumors. In human pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer, CLDN18 expression positively correlated with more differentiated histology and favorable prognosis. CLDN18 on the cell surface promoted accrual of cytotoxic T lymphocytes (CTLs), facilitating direct CTL contacts with tumor cells by driving the mobilization of the adhesion protein ALCAM to the lipid rafts of the tumor cell membrane through actin. This process favored the formation of robust immunological synapses (ISs) between CTLs and CLDN18-positive cancer cells, resulting in increased T cell activation. Our data reveal an immune role for CLDN18 in orchestrating T cell infiltration and shaping the tumor immune contexture.
De Sanctis, Francesco
Author
Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listDusi, Silvia
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listCaligola, Simone
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listAnselmi, Cristina
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listPetrova, Varvara
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listRossi, Barbara
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listAngelini, Gabriele
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listErdeljan, Michael
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listWöll, Stefan
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listSchlitter, Anna Melissa
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listMetzler, Thomas
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listSteiger, Katja
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listBorok, Zea
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listBailey, Peter
Author
Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listBauer, Aline
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listHalin, Cornelia
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listBoschi, Federico
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listGiugno, Rosalba
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listCanè, Stefania
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listLawlor, Rita
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listCorbo, Vincenzo
Author
Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723
See full publications listScarpa, Aldo
Author
Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listConstantin, Gabriela
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listUgel, Stefano
Author
Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listVascotto, Fulvia
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listSahin, Ugur
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listTüreci, Özlem
Author
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
See full publications listBronte, Vincenzo
Author
Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613
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