De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

Abstract

Tumors weakly infiltrated by T lymphocytes poorly respond to immunotherapy. We aimed to unveil malignancy-associated programs regulating T cell entrance, arrest, and activation in the tumor environment. Differential expression of cell adhesion and tissue architecture programs, particularly the presence of the membrane tetraspanin claudin (CLDN)18 as a signature gene, demarcated immune-infiltrated from immune-depleted mouse pancreatic tumors. In human pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer, CLDN18 expression positively correlated with more differentiated histology and favorable prognosis. CLDN18 on the cell surface promoted accrual of cytotoxic T lymphocytes (CTLs), facilitating direct CTL contacts with tumor cells by driving the mobilization of the adhesion protein ALCAM to the lipid rafts of the tumor cell membrane through actin. This process favored the formation of robust immunological synapses (ISs) between CTLs and CLDN18-positive cancer cells, resulting in increased T cell activation. Our data reveal an immune role for CLDN18 in orchestrating T cell infiltration and shaping the tumor immune contexture.

People
De Sanctis, Francesco
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Dusi, Silvia
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Caligola, Simone
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Anselmi, Cristina
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Petrova, Varvara
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Rossi, Barbara
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Angelini, Gabriele
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Erdeljan, Michael
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Wöll, Stefan
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Schlitter, Anna Melissa
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Metzler, Thomas
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Steiger, Katja
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Borok, Zea
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Bailey, Peter
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Bauer, Aline
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Halin, Cornelia
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Boschi, Federico
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Giugno, Rosalba
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Canè, Stefania
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Lawlor, Rita
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Corbo, Vincenzo
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723

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Scarpa, Aldo
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Constantin, Gabriela
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Ugel, Stefano
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Vascotto, Fulvia
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Sahin, Ugur
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Türeci, Özlem
Author

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Bronte, Vincenzo
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

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Title:
Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer
Creators:
De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo
Identification Number:
10.1016/j.immuni.2024.04.021
Date:
11 June 2024
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:
Elsevier (Cell Press)
Additional Information:
s. Funding: this work was jointly supported by Cancer Research Institute (CRI, CLIP PI: V.B., project CRI3118); Associazione Italiana per la Ricerca sul Cancro (AIRC, PI: V.B., project 23788; PI: S.U., project: 21509; PI: A.S., project: 26343); PRIN programs of the Italian Ministry of Education, University, and Research (MIUR, PI: V.B., CUP: B38D19000260006; PI: S.U., CUP: B38D19000140006; PI: F.D.S., CUP: B39J22001200001); PNRR program project: MAD-2022-12375871 (PI: V.B., CUP J93C22002250006), and PNRR project MNESYS PE00000006 (PI: G.C., CUP: B33C22001060002). This research was also funded by Italian Ministry of Health Ricerca Corrente.
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URI:
https://pub.demo35.eprints-hosting.org/id/eprint/234
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
SWORD Depositor:
Users 37347 not found.
Date Deposited:
11 Jun 2025 16:36
Revision:
12
Last Modified:
12 Jun 2025 10:36
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