Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

Abstract

Synthetic biology (SynBio) offers transformative solutions for addressing environmental challenges by engineering organisms capable of degrading pollutants, enhancing carbon sequestration, and valorizing waste (Figure 1). These innovations hold the potential to revolutionize bioremediation strategies, ecosystem restoration, and sustainable environmental management. (1) Advances in SynBio, including automation, precise manipulation of genetic material, (2) and design of semisynthetic organisms with enhanced capabilities, can improve the efficiency of microbes for eliminating pollutants such as hydrocarbons and plastics or extracting valuable resources from the environment. (3) Genome editing technologies, such as CRISPR-Cas9, allows the editing of genomes with unprecedented accuracy, facilitating the development of organisms with desired traits or functions. (4) Furthermore, SynBio encompasses the engineering of metabolic enzymes within organisms, leading to the design of microbial factories capable of degrading complex and persistent chemicals, and converting waste to valuable resources. (5) These advancements also facilitate the manipulation of bacterial social behaviors, offering the capacity for tunable control at the multicellular level and engineered biofilms. (5)

People
Hassard, Francis
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Curtis, Thomas P.
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Dotro, Gabriela C.
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Golyshin, Peter
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Gutierrez, Tony
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Heaven, Sonia
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Horsfall, Louise
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Jefferson, Bruce
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Jones, Davey L.
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Krasnogor, Natalio
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Kumar, Vinod
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Lea-Smith, David J.
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Le Corre Pidou, Kristell
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Liu, Yongqiang
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Lyu, Tao
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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McCarthy, Ronan R.
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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McKew, Boyd
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Smith, Cindy
Author

Cholet, Fabien and Vignola, Marta and Quinn, Dominic and Ijaz, Umer Z. and Sloan, William T. and Smith, Cindy J. (2025) Microbial ecology of drinking water biofiltration based on 16S rRNA sequencing: a meta-analysis. Water Research, 281: 123684. ISSN 0043-1354

Fantinelli Franco, Fabiane and Malik, Muhammad and Manjakkal, Libu and Roshanghias, Ali and Smith, Cindy and Gauchotte-Lindsay, Caroline (2024) Optimising carbon structures in laser-induced graphene electrodes using design of experiments for enhanced electrochemical sensing characteristics. ACS Applied Materials and Interfaces, 16 (47). pp. 65489-65502. ISSN 1944-8244

Fantinelli Franco, Fabiane and Malik, Muhammad Hassan and Manjakkal, Libu and Roshanghias, Ali and Smith, Cindy J. and Gauchotte-Lindsay, Caroline (2024) Optimizing carbon structures in laser-induced graphene electrodes using design of experiments for enhanced electrochemical sensing characteristics. ACS Applied Materials and Interfaces, 16 (47). pp. 65489-65502. ISSN 1944-8244

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Yakunin, Alexander
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Yang, Zhugen
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Zhang, Yue
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Coulon, Frederic
Author

Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic (2024) Scaling-up engineering biology for enhanced environmental solutions. ACS Synthetic Biology, 13 (6). pp. 1586-1588. ISSN 2161-5063

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Title:
Scaling-up engineering biology for enhanced environmental solutions
Creators:
Hassard, Francis and Curtis, Thomas P. and Dotro, Gabriela C. and Golyshin, Peter and Gutierrez, Tony and Heaven, Sonia and Horsfall, Louise and Jefferson, Bruce and Jones, Davey L. and Krasnogor, Natalio and Kumar, Vinod and Lea-Smith, David J. and Le Corre Pidou, Kristell and Liu, Yongqiang and Lyu, Tao and McCarthy, Ronan R. and McKew, Boyd and Smith, Cindy and Yakunin, Alexander and Yang, Zhugen and Zhang, Yue and Coulon, Frederic
Identification Number:
10.1021/acssynbio.4c00292
Date:
21 June 2024
Divisions:
College of Science and Engineering > School of Engineering > Infrastructure and Environment
Publisher:
American Chemical Society
Additional Information:
This work is funded by Biotechnology and Biological Sciences Research Council (BBSRC) through an Engineering Biology Hub award (grant number: BB/Y008332/1).
Library
URI:
https://pub.demo35.eprints-hosting.org/id/eprint/226
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
Date Deposited:
11 Jun 2025 16:36
Revision:
11
Last Modified:
12 Jun 2025 10:49
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