Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

Abstract

Objective: The dysregulation of the axon guidance pathway is common in pancreatic ductal adenocarcinoma (PDAC), yet our understanding of its biological relevance is limited. Here, we investigated the functional role of the axon guidance cue SEMA3A in supporting PDAC progression.

Design: We integrated bulk and single-cell transcriptomic datasets of human PDAC with in situ hybridisation analyses of patients’ tissues to evaluate SEMA3A expression in molecular subtypes of PDAC. Gain and loss of function experiments in PDAC cell lines and organoids were performed to dissect how SEMA3A contributes to define a biologically aggressive phenotype.

Results: In PDAC tissues, SEMA3A is expressed by stromal elements and selectively enriched in basal-like/squamous epithelial cells. Accordingly, expression of SEMA3A in PDAC cells is induced by both cell-intrinsic and cell-extrinsic determinants of the basal-like phenotype. In vitro, SEMA3A promotes cell migration as well as anoikis resistance. At the molecular level, these phenotypes are associated with increased focal adhesion kinase signalling through canonical SEMA3A-NRP1 axis. SEMA3A provides mouse PDAC cells with greater metastatic competence and favours intratumoural infiltration of tumour-associated macrophages and reduced density of T cells. Mechanistically, SEMA3A functions as chemoattractant for macrophages and skews their polarisation towards an M2-like phenotype. In SEMA3Ahigh tumours, depletion of macrophages results in greater intratumour infiltration by CD8+T cells and better control of the disease from antitumour treatment.

Conclusions: Here, we show that SEMA3A is a stress-sensitive locus that promotes the malignant phenotype of basal-like PDAC through both cell-intrinsic and cell-extrinsic mechanisms.

People
Lupo, Francesca
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Pezzini, Francesco
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Pasini, Davide
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Fiorini, Elena
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Adamo, Annalisa
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Veghini, Lisa
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Bevere, Michele
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Frusteri, Cristina
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Delfino, Pietro
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
D'agosto, Sabrina
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Andreani, Silvia
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Piro, Geny
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723

See full publications list
Malinova, Antonia
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Wang, Tian
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
De Sanctis, Francesco
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

See full publications list
Lawlor, Rita Teresa
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Hwang, Chang-Il
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Carbone, Carmine
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723

See full publications list
Amelio, Ivano
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Bailey, Peter
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

See full publications list
Bronte, Vincenzo
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

See full publications list
Tuveson, David
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

See full publications list
Scarpa, Aldo
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

See full publications list
Ugel, Stefano
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

See full publications list
Corbo, Vincenzo
Author

Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo (2024) Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC. Gut, 73 (8). pp. 1321-1335. ISSN 0017-5749

De Sanctis, Francesco and Dusi, Silvia and Caligola, Simone and Anselmi, Cristina and Petrova, Varvara and Rossi, Barbara and Angelini, Gabriele and Erdeljan, Michael and Wöll, Stefan and Schlitter, Anna Melissa and Metzler, Thomas and Steiger, Katja and Borok, Zea and Bailey, Peter and Bauer, Aline and Halin, Cornelia and Boschi, Federico and Giugno, Rosalba and Canè, Stefania and Lawlor, Rita and Corbo, Vincenzo and Scarpa, Aldo and Constantin, Gabriela and Ugel, Stefano and Vascotto, Fulvia and Sahin, Ugur and Türeci, Özlem and Bronte, Vincenzo (2024) Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity, 57 (6). 1378-1393.e14. ISSN 1074-7613

Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723

See full publications list
Texts
194:202
lightbox image
325869.pdf - Published Version
Available under License Creative Commons Attribution.

Download (11MB) | Preview
Information
Title:
Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC
Creators:
Lupo, Francesca and Pezzini, Francesco and Pasini, Davide and Fiorini, Elena and Adamo, Annalisa and Veghini, Lisa and Bevere, Michele and Frusteri, Cristina and Delfino, Pietro and D'agosto, Sabrina and Andreani, Silvia and Piro, Geny and Malinova, Antonia and Wang, Tian and De Sanctis, Francesco and Lawlor, Rita Teresa and Hwang, Chang-Il and Carbone, Carmine and Amelio, Ivano and Bailey, Peter and Bronte, Vincenzo and Tuveson, David and Scarpa, Aldo and Ugel, Stefano and Corbo, Vincenzo
Identification Number:
10.1136/gutjnl-2023-329807
Date:
11 July 2024
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:
BMJ Publishing Group
Additional Information:
VC is supported by Associazione Italiana Ricerca sul Cancro (AIRC; grant no. 18178; 28801). VC is also supported by the EU (MSCA project PRECODE, grant No: 861196), the National Cancer Institute (NCI, HHSN26100008) and Fondazione Nadia Valsecchi Onlus. AS is supported by AIRC (26343); EF was supported by AIRC (25286;29692). LV was supported by AIRC (29528). PD has been supported by Fondazione Nadia Valsecchi Onlus and Fondazione Umberto Veronesi. MB is supported by AIRC fellowship for Italy (28054) and Fondazione Nadia Valsecchi Onlus. GP is supported by AIRC (MFAG AIRC; grant no. 29224). CC is supported by AIRC (MFAG AIRC Grant ’Luigi Bonatti e Anna Maria Bonatti Rocca’; grant no. 23681). This study was conducted with the support of the Ontario Institute for Cancer Research through funding provided by the Government of Ontario. This work has been supported by the DFG under the TRR353/1 “Death Decision” project A05 to IA.
Library
URI:
https://pub.demo35.eprints-hosting.org/id/eprint/194
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
SWORD Depositor:
Users 37347 not found.
Date Deposited:
11 Jun 2025 16:35
Revision:
12
Last Modified:
12 Jun 2025 11:58
View Item