Farndale, Lucas and Insall, Robert and Yuan, Ke (2025) TriDeNT: Triple deep network training for privileged knowledge distillation in histopathology. Medical Image Analysis, 102: 103479. ISSN 1361-8415
AI Summary:
TriDeNT is a novel self-supervised method that utilises privileged data not available during inference to improve performance. The method outperforms other state-of-the-art methods in downstream tasks, with observed improvements of up to 101.AI Topics:
Computational pathology models rarely utilise data that will not be available for inference. This means most models cannot learn from highly informative data such as additional immunohistochemical (IHC) stains and spatial transcriptomics. We present TriDeNT, a novel self-supervised method for utilising privileged data that is not available during inference to improve performance. We demonstrate the efficacy of this method for a range of different paired data including immunohistochemistry, spatial transcriptomics and expert nuclei annotations. In all settings, TriDeNT outperforms other state-of-the-art methods in downstream tasks, with observed improvements of up to 101%. Furthermore, we provide qualitative and quantitative measurements of the features learned by these models and how they differ from baselines. TriDeNT offers a novel method to distil knowledge from scarce or costly data during training, to create significantly better models for routine inputs.
Title | TriDeNT: Triple deep network training for privileged knowledge distillation in histopathology |
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Creators | Farndale, Lucas and Insall, Robert and Yuan, Ke |
Identification Number | 10.1016/j.media.2025.103479 |
Date | May 2025 |
Divisions | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Publisher | Elsevier |
Additional Information | Lucas Farndale is supported by the MRC, United Kingdom grant MR/W006804/1, Robert Insall is supported by EPSRC, United Kingdom grant EP/S0300875/1 and Wellcome grant, United Kingdom 221786/Z/20/Z. Ke Yuan acknowledges support from EPSRC, United Kingdom EP/R018634/1, Cancer Research UK (EDDPGM-Nov21/100001 and DRCMDP-Nov23/100010), BBSRC BB/V016067/1 and Prostate Cancer UK MA-TIA22-001. |
URI | https://pub.demo35.eprints-hosting.org/id/eprint/15 |
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Item Type | Article |
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Depositing User | Unnamed user with email ejo1f20@soton.ac.uk |
Date Deposited | 11 Jun 2025 16:34 |
Revision | 24 |
Last Modified | 12 Jun 2025 12:40 |
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