Neilly, Mark D.J. and Dick, Craig and Blyth, Kevin G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14: 7. ISSN 2199-2428
AI Summary:
Non-Specific Pleuritis (NSP) is a common diagnosis following thoracoscopy, encompassing a broad range of aetiologies with heterogeneous outcomes. The disease typically runs a benign course, but the biomechanical consequences of subsequent tissue re-modelling can be severe.AI Topics:
Purpose of Review:
Non-Specific Pleuritis (NSP) is a common diagnosis following thoracoscopy and encompasses a broad range of aetiologies with heterogeneous outcomes. In this article, we review pathophysiology, associated syndromes, and current best practice in follow-up.
Recent Findings:
NSP typically runs a benign disease course; however, the biomechanical consequences of subsequent tissue re-modelling can be severe. A proportion of patients develop malignancy, notably pleural mesothelioma (PM), and clinicians currently lack the ability to stratify those at risk. Some may be harbouring occult malignancy with false-negative pleural biopsies. Alternatively, NSP may represent a true pre-PM precursor supported by the recent characterisation of mesothelioma-in-situ.
Summary:
Prospective surveillance of NSP patients could unlock the final biological milestone preceding PM evolution. Progress in this area would permit a more personalised patient stratification, whilst offering novel opportunities for translational research. The PREDICT-Meso International Accelerator Network has been established to focus on this goal.
Neilly, Mark
Author
Neilly, Mark D.J. and Dick, Craig and Blyth, Kevin G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14: 7. ISSN 2199-2428
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listDick, Craig
Author
Neilly, Mark D.J. and Dick, Craig and Blyth, Kevin G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14: 7. ISSN 2199-2428
See full publications listBlyth, Kevin
Author
Alkarn, Ahmed and Stapleton, Liam J. and Eleftheriou, Dimitra and Stewart, Laura and Chalmers, George and Hamed, Ahmad and Hussein, Khaled and Blyth, Kevin G. and van der Hors, Joris C. and Maclay, John D. (2025) Real life pre-operative nodal staging accuracy in non-small cell lung cancer and its relationship with survival. Diagnostics, 15 (4): 430. ISSN 2075-4418
Neilly, Mark D.J. and Dick, Craig and Blyth, Kevin G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14: 7. ISSN 2199-2428
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See full publications listAvailable under License Creative Commons Attribution.
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