Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
AI Summary:
This study investigated the effects of obesity on systemic inflammatory response and clinical outcomes in patients undergoing robotic-assisted surgery for left-sided colorectal cancer resections. The results showed that greater comorbidity was associated with postoperative systemic inflammatory response and clinical outcomes, but not with obesity.AI Topics:
Obesity (BMI > 30 kg/m2) is rapidly increasing worldwide with 26% of the UK population being obese and 38% being overweight. Obesity is intimately related to several life-limiting conditions including colorectal cancer (CRC). Obese patients have a higher degree of perioperative systemic inflammatory response (SIR) and an increased risk of perioperative complications. The aim of this current study was to investigate whether robotic-assisted surgery mitigates the effects of obesity in left sided CRC resections on the SIR and clinical outcomes. All patients undergoing left-sided colorectal cancer resections from May 2021 to May 2023 were, prospectively, entered into a database with patient characteristics and perioperative short-term outcomes recorded. CRP was considered a surrogate for SIR. The relationship between obesity and complications were examined using Chi Square for linear association, Kruskal–Wallis for continuous data and multivariate binary logistic regression model. 221 patients who underwent RAS for left-sided CRC were analysed. Obesity was associated with more comorbidity (ASA, p < 0.01) and SSI (p < 0.05) but not with age, sex, procedure or pathology. POD3 CRP < 150 mg/l was also associated with obesity (p < 0.01). In turn, greater comorbidity was associated with age (p < 0.001), site of resection (p < 0.05), SSI (p < 0.05), postoperative blood transfusion (p < 0.01) and LOS (p < 0.001). On multivariate analysis, only greater ASA (p < 0.05) and surgical procedure (p < 0.01) were associated with the development of an SSI independently. Greater comorbidity but not obesity was independently associated with postoperative SIR and clinical outcomes in patients undergoing RAS. These results support the use of RAS for left sided CRC resections, particularly in the obese.
Ingham, Abigail R.
Author
Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
See full publications listMcSorley, Steven T.
Author
Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377
Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
Brown, Leo R. and Thomson, Georgina G. and Gardner, Ellen and Chien, Siobhan and McGovern, Josh and Dolan, Ross D. and McSorley, Stephen T. and Forshaw, Matthew J. and McMillan, Donald C. and Wigmore, Stephen J. and Crumley, AndrewB. and Skipworth, Richard J.E. (2024) Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study. British Journal of Surgery, 111 (4): znae098. ISSN 0007-1323
See full publications listMcMillan, D.C.
Author
Bradley, Nicholas A. and Walter, Amy and Sankey, Chiara and Wilson, Alasdair and Siddiqui, Tamim and Roxburgh, Campbell D. and McMillan, Donald C. and Guthrie, Graeme J.K. (2025) Longitudinal association between statins and changes in CT derived body composition in patients with abdominal aortic aneurysm. Journal of Cachexia, Sarcopenia and Muscle, 16 (2). ISSN 2190-5991
Thompson, Joshua J. and MacLeod, Nicholas and Will, Sarah and O'Rourke, Fraser and McGovern, Josh and Roxburgh, Campbell and Edwards, Joanne and Dolan, Ross D. and McMillan, Donald C. (2025) The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. BMC Cancer, 25: 543. ISSN 1471-2407
Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377
See full publications listChong, David
Author
Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
Ingham,, Abigail R. and Kong, Chia Yew and Wong, Tin-Ning and McSorley, Stephen T. and McMillan, Donald C. and Nicholson, Gary A. and Alani, Ahmed and Mansouri, David and Chong, David and Mackay, Graham J. and Roxburgh, Campbell S.D. (2024) Robotic-assisted surgery for left sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study. Surgical Endoscopy. ISSN 0930-2794
See full publications listMackay, Graham J.
Author
Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
Ingham,, Abigail R. and Kong, Chia Yew and Wong, Tin-Ning and McSorley, Stephen T. and McMillan, Donald C. and Nicholson, Gary A. and Alani, Ahmed and Mansouri, David and Chong, David and Mackay, Graham J. and Roxburgh, Campbell S.D. (2024) Robotic-assisted surgery for left sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study. Surgical Endoscopy. ISSN 0930-2794
See full publications listWrobel, Aleksandra
Author
Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
See full publications listKong, Chia Yew
Author
Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
Ingham,, Abigail R. and Kong, Chia Yew and Wong, Tin-Ning and McSorley, Stephen T. and McMillan, Donald C. and Nicholson, Gary A. and Alani, Ahmed and Mansouri, David and Chong, David and Mackay, Graham J. and Roxburgh, Campbell S.D. (2024) Robotic-assisted surgery for left sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study. Surgical Endoscopy. ISSN 0930-2794
See full publications listAlani, Ahmed
Author
Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
Ingham,, Abigail R. and Kong, Chia Yew and Wong, Tin-Ning and McSorley, Stephen T. and McMillan, Donald C. and Nicholson, Gary A. and Alani, Ahmed and Mansouri, David and Chong, David and Mackay, Graham J. and Roxburgh, Campbell S.D. (2024) Robotic-assisted surgery for left sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study. Surgical Endoscopy. ISSN 0930-2794
See full publications listNicholson, Gary
Author
Ingham, Abigail R. and McSorley, Stephen T. and McMillan, Donald C. and Chong, David and Mackay, Graham J. and Wrobel, Aleksandra and Kong, Chia Yew and Alani, Ahmed and Nicholson, Gary and Roxburgh, Campbell S.D. (2025) Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections? Journal of Robotic Surgery, 19 (1): 98. ISSN 1863-2483
See full publications listRoxburgh, Campbell S. D.
Author
Bradley, Nicholas A. and Walter, Amy and Sankey, Chiara and Wilson, Alasdair and Siddiqui, Tamim and Roxburgh, Campbell D. and McMillan, Donald C. and Guthrie, Graeme J.K. (2025) Longitudinal association between statins and changes in CT derived body composition in patients with abdominal aortic aneurysm. Journal of Cachexia, Sarcopenia and Muscle, 16 (2). ISSN 2190-5991
Thompson, Joshua J. and MacLeod, Nicholas and Will, Sarah and O'Rourke, Fraser and McGovern, Josh and Roxburgh, Campbell and Edwards, Joanne and Dolan, Ross D. and McMillan, Donald C. (2025) The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. BMC Cancer, 25: 543. ISSN 1471-2407
Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377
See full publications listAvailable under License Creative Commons Attribution.
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