Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
AI Summary:
The study found that positive surgical margins (PSMs) in pT2 prostate cancer are associated with higher rates of biochemical recurrence. The introduction of centralisation via robotic surgery did not impact PSM occurrence or biochemical recurrence.AI Topics:
Background:
To assess how centralisation of cancer services via robotic surgery influenced positive surgical margin (PSM) occurrence and its associated risk of biochemical recurrence (BCR) in cases of pT2 prostate cancer (PC).
Methods:
Retrospective analysis of all radical prostatectomy (RP) cases performed in the West of Scotland during the period from January 2013 to June 2022. Primary outcomes were PSM and BCR. The secondary outcomes compared the impact of centralisation and surgical approach on PSM and BCR; and margin length and location on BCR. Propensity score matching and Cox regression models were performed using R.
Results:
A total of, 907 patients were included; 662 robot assisted radical prostatectomy (RARP), 245 open RP. PSM rate was 17.7% (161/907), similar in RARP and open cohorts. Patients with PSM had higher rates of BCR; 26.7%, compared to 8.7% in patients with no PSM. Patients with margins of ≥ 1 mm had higher risk of developing BCR. Patients who underwent open RP had increased incidence of PSM ≥ 1 mm; 40/43 (93%) compared to 83/117 (71%) in robotic approach (p = 0.003). Limitations include the study being retrospective, introduction of centralisation and robot concurrently, and evolution of practice.
Discussion:
PSMs in pT2 PC are associated with higher rates of BCR. Introduction of centralisation via the robot had no impact on PSM occurrence or BCR, although did demonstrate a reduction in PSM length.
Ibrahim, Ibrahim
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
See full publications listKouli, Omar
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
See full publications listIlangovan, Sanjana
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
See full publications listSneddon, Melanie
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
See full publications listNalagatla, Sarika
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
See full publications listMarshall, Carol
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
See full publications listDutto, Lorenzo
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
Taggart, Ruairidh and Dutto, Lorenzo and Leung, Hing Y. and Salji, Mark and Ahmad, Imran (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP). Cancer Medicine, 12 (22). pp. 20830-20837. ISSN 2045-7634
See full publications listLeung, Hing Y.
Author
Dehghani, Parisa and Salehirozveh, Mostafa and Tajabadi, Ataollah and Yeung, Chi Chung and Lam, Michael and Leung, Hing Y. and Roy, Vellaisamy A.L. (2025) Next-gen point-of-care tool for ultra-sensitive detection of urinary spermine for prostate cancer diagnosis. ACS Sensors, 10 (4). pp. 2640-2651. ISSN 2379-3694
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
Dehghani, Parisa and Karthikeyan, Vaithinathan and Tajabadi, Ataollah and Assi, Dani S. and Catchpole, Anthony and Wadsworth, John and Leung, Hing Y. and Roy, Vellaisamy A.L. (2024) Rapid near-patient impedimetric sensing platform for prostate cancer diagnosis. ACS Omega, 9 (12). pp. 14580-14591. ISSN 2470-1343
See full publications listAhmad, Imran
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
Mariappan, Paramananthan and Johnston, Allan and Trail, Matthew and Hamid, Sami and Hollins, Graham and Dreyer, Barend A and Ramsey, Sara and Padovani, Luisa and Garau, Roberta and Enriquez, Julia Guerrero and Boden, Alasdair and Maresca, Gianluca and Simpson, Helen and Hasan, Rami and Sharpe, Claire and Thomas, Benjamin G. and Chaudhry, Altaf H. and Khan, Rehan S. and Bhatt, Jaimin R. and Ahmad, Imran and Nandwani, Ghulam M and Dimitropoulos, Konstantinos and Makaroff, Lydia and Shaw, Johnstone and Graham, Catriona and Hendry, David (2024) Achieving benchmarks for national quality indicators reduces recurrence and progression in non-muscle-invasive bladder cancer. European Urology Oncology, 7 (6). pp. 1327-1337. ISSN 2588-9311
Taggart, Ruairidh and Dutto, Lorenzo and Leung, Hing Y. and Salji, Mark and Ahmad, Imran (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP). Cancer Medicine, 12 (22). pp. 20830-20837. ISSN 2045-7634
See full publications listAvailable under License Creative Commons Attribution.
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