Heron, Rosalind and Amato, Clelia and Wood, Will and Davidson, Andrew J. (2023) Understanding the diversity and dynamics of in vivo efferocytosis: insights from the fly embryo. Immunological Reviews, 319 (1). pp. 27-44. ISSN 0105-2896
AI Summary:
The clearance of dead and dying cells, termed efferocytosis, is a rapid and efficient process. The fly embryo has emerged as a powerful model to study this process.AI Topics:
The clearance of dead and dying cells, termed efferocytosis, is a rapid and efficient process and one that is critical for organismal health. The extraordinary speed and efficiency with which dead cells are detected and engulfed by immune cells within tissues presents a challenge to researchers who wish to unravel this fascinating process, since these fleeting moments of uptake are almost impossible to catch in vivo. In recent years, the fruit fly (Drosophila melanogaster) embryo has emerged as a powerful model to circumvent this problem. With its abundance of dying cells, specialist phagocytes and relative ease of live imaging, the humble fly embryo provides a unique opportunity to catch and study the moment of cell engulfment in real‐time within a living animal. In this review, we explore the recent advances that have come from studies in the fly, and how live imaging and genetics have revealed a previously unappreciated level of diversity in the efferocytic program. A variety of efferocytic strategies across the phagocytic cell population ensure efficient and rapid clearance of corpses wherever death is encountered within the varied and complex setting of a multicellular living organism.
Title | Understanding the diversity and dynamics of in vivo efferocytosis: insights from the fly embryo |
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Creators | Heron, Rosalind and Amato, Clelia and Wood, Will and Davidson, Andrew J. |
Identification Number | 10.1111/imr.13266 |
Date | October 2023 |
Divisions | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Publisher | Wiley |
Additional Information | RH was supported by a Horizon Europe Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship (894935). CA was supported by a Sir Henry Wellcome Postdoctoral fellowship (218627/Z/19/Z). AJD and WW were supported by a Wellcome Trust Investigator Award to WW (22460/Z/21/Z). |
URI | https://pub.demo35.eprints-hosting.org/id/eprint/496 |
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Item Type | Article |
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Depositing User | Unnamed user with email ejo1f20@soton.ac.uk |
SWORD Depositor | Users 37347 not found. |
Date Deposited | 11 Jun 2025 16:38 |
Revision | 15 |
Last Modified | 12 Jun 2025 09:06 |
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