Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

Abstract

To fuel accelerated proliferation, leukaemic cells undergo metabolic deregulation, which can result in specific nutrient dependencies. Here, we perform an amino acid drop-out screen and apply pre-clinical models of chronic phase chronic myeloid leukaemia (CML) to identify arginine as a nutrient essential for primary human CML cells. Analysis of the Microarray Innovations in Leukaemia (MILE) dataset uncovers reduced ASS1 levels in CML compared to most other leukaemia types. Stable isotope tracing reveals repressed activity of all urea cycle enzymes in patient-derived CML CD34+ cells, rendering them arginine auxotrophic. Thus, arginine deprivation completely blocks proliferation of CML CD34+ cells and induces significantly higher levels of apoptosis when compared to arginine-deprived cell lines. Similarly, primary CML cells, but not normal CD34+ samples, are particularly sensitive to treatment with the arginine-depleting enzyme, BCT-100, which induces apoptosis and reduces clonogenicity. Moreover, BCT-100 is highly efficacious in a patient-derived xenograft model, causing > 90% reduction in the number of human leukaemic stem cells (LSCs). These findings indicate arginine depletion to be a promising and novel strategy to eradicate therapy resistant LSCs.

People
Rattigan, Kevin M.
Author

Khalaf, Ahmed and de Beauchamp, Lucie and Kalkman, Eric and Rattigan, Kevin and Himonas, Ekaterini and Jones, Joe and James, Daniel and Shokry, Engy Shokry Abd and Scott, Mary T. and Dunn, Karen and Tardito, Saverio and Copland, Mhairi and Sumpton, David and Shanks, Emma and Helgason, Vignir (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16 (751): eadi5336. ISSN 1946-6234

Zarou, Martha M. and Rattigan, Kevin M. and Sarnello, Daniele and Shokry, Engy and Dawson, Amy and Ianniciello, Angela and Dunn, Karen and Copland, Mhairi and Sumpton, David and Vazquez, Alexei and Helgason, Vignir (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15: 1931. ISSN 2041-1723

Rattigan, Kevin M. (2024) Mini review of metabolism in leukaemia: from complexity to the clinic. Frontiers in Hematology, 2: 1353994. ISSN 2813-3935

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Zarou, Martha M.
Author

Dawson, Amy and Zarou, Martha M. and Prasad, Bodhayan and Bittencourt-Silvestre, Joana and Zerbst, Désirée and Himonas, Ekaterini and Hsieh, Ya-Ching and van Loon, Isabel and Rodriguez Blanco, Giovanny and Ianniciello, Angela and Kerekes, Zsombor and Krishnan, Vaidehi and Agarwal, Puneet and Almasoudi, Hassan and McCluskey, Laura and Hopcroft, Lisa E.M. and Scott, Mary T. and Baquero, Pablo and Dunn, Karen and Vetrie, David and Copland, Mhairi and Bhatia, Ravi and Coffelt, Seth B. and Tiong, Ong Sin and Wheadon, Helen and Zanivan, Sara and Kirschner, Kristina and Helgason, G. Vignir (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15: 1090. ISSN 2041-1723

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

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Brabcova, Zuzana
Author

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

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Prasad, Bodhayan
Author

Dawson, Amy and Zarou, Martha M. and Prasad, Bodhayan and Bittencourt-Silvestre, Joana and Zerbst, Désirée and Himonas, Ekaterini and Hsieh, Ya-Ching and van Loon, Isabel and Rodriguez Blanco, Giovanny and Ianniciello, Angela and Kerekes, Zsombor and Krishnan, Vaidehi and Agarwal, Puneet and Almasoudi, Hassan and McCluskey, Laura and Hopcroft, Lisa E.M. and Scott, Mary T. and Baquero, Pablo and Dunn, Karen and Vetrie, David and Copland, Mhairi and Bhatia, Ravi and Coffelt, Seth B. and Tiong, Ong Sin and Wheadon, Helen and Zanivan, Sara and Kirschner, Kristina and Helgason, G. Vignir (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15: 1090. ISSN 2041-1723

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

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Zerbst, Désirée
Author

Dawson, Amy and Zarou, Martha M. and Prasad, Bodhayan and Bittencourt-Silvestre, Joana and Zerbst, Désirée and Himonas, Ekaterini and Hsieh, Ya-Ching and van Loon, Isabel and Rodriguez Blanco, Giovanny and Ianniciello, Angela and Kerekes, Zsombor and Krishnan, Vaidehi and Agarwal, Puneet and Almasoudi, Hassan and McCluskey, Laura and Hopcroft, Lisa E.M. and Scott, Mary T. and Baquero, Pablo and Dunn, Karen and Vetrie, David and Copland, Mhairi and Bhatia, Ravi and Coffelt, Seth B. and Tiong, Ong Sin and Wheadon, Helen and Zanivan, Sara and Kirschner, Kristina and Helgason, G. Vignir (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15: 1090. ISSN 2041-1723

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

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Sarnello, Daniele
Author

Zarou, Martha M. and Rattigan, Kevin M. and Sarnello, Daniele and Shokry, Engy and Dawson, Amy and Ianniciello, Angela and Dunn, Karen and Copland, Mhairi and Sumpton, David and Vazquez, Alexei and Helgason, Vignir (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15: 1931. ISSN 2041-1723

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

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Kalkman, Eric R.
Author

Khalaf, Ahmed and de Beauchamp, Lucie and Kalkman, Eric and Rattigan, Kevin and Himonas, Ekaterini and Jones, Joe and James, Daniel and Shokry, Engy Shokry Abd and Scott, Mary T. and Dunn, Karen and Tardito, Saverio and Copland, Mhairi and Sumpton, David and Shanks, Emma and Helgason, Vignir (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16 (751): eadi5336. ISSN 1946-6234

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

See full publications list
Ianniciello, Angela
Author

Zarou, Martha M. and Rattigan, Kevin M. and Sarnello, Daniele and Shokry, Engy and Dawson, Amy and Ianniciello, Angela and Dunn, Karen and Copland, Mhairi and Sumpton, David and Vazquez, Alexei and Helgason, Vignir (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15: 1931. ISSN 2041-1723

Dawson, Amy and Zarou, Martha M. and Prasad, Bodhayan and Bittencourt-Silvestre, Joana and Zerbst, Désirée and Himonas, Ekaterini and Hsieh, Ya-Ching and van Loon, Isabel and Rodriguez Blanco, Giovanny and Ianniciello, Angela and Kerekes, Zsombor and Krishnan, Vaidehi and Agarwal, Puneet and Almasoudi, Hassan and McCluskey, Laura and Hopcroft, Lisa E.M. and Scott, Mary T. and Baquero, Pablo and Dunn, Karen and Vetrie, David and Copland, Mhairi and Bhatia, Ravi and Coffelt, Seth B. and Tiong, Ong Sin and Wheadon, Helen and Zanivan, Sara and Kirschner, Kristina and Helgason, G. Vignir (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15: 1090. ISSN 2041-1723

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

See full publications list
Scott, Mary T.
Author

Khalaf, Ahmed and de Beauchamp, Lucie and Kalkman, Eric and Rattigan, Kevin and Himonas, Ekaterini and Jones, Joe and James, Daniel and Shokry, Engy Shokry Abd and Scott, Mary T. and Dunn, Karen and Tardito, Saverio and Copland, Mhairi and Sumpton, David and Shanks, Emma and Helgason, Vignir (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16 (751): eadi5336. ISSN 1946-6234

Dawson, Amy and Zarou, Martha M. and Prasad, Bodhayan and Bittencourt-Silvestre, Joana and Zerbst, Désirée and Himonas, Ekaterini and Hsieh, Ya-Ching and van Loon, Isabel and Rodriguez Blanco, Giovanny and Ianniciello, Angela and Kerekes, Zsombor and Krishnan, Vaidehi and Agarwal, Puneet and Almasoudi, Hassan and McCluskey, Laura and Hopcroft, Lisa E.M. and Scott, Mary T. and Baquero, Pablo and Dunn, Karen and Vetrie, David and Copland, Mhairi and Bhatia, Ravi and Coffelt, Seth B. and Tiong, Ong Sin and Wheadon, Helen and Zanivan, Sara and Kirschner, Kristina and Helgason, G. Vignir (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15: 1090. ISSN 2041-1723

Scott, Mary T. and Liu, Wei and Mitchell, Rebecca and Clarke, Cassie J. and Kinstrie, Ross and Warren, Felix and Almasoudi, Hassan and Stevens, Thomas and Dunn, Karen and Pritchard, John and Drotar, Mark E. and Michie, Alison M. and Jorgensen, Heather G. and Higgins, Brian and Copland, Mhairi and Vetrie, David (2024) Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature Communications, 15: 651. ISSN 2041-1723

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Dunn, Karen M.
Author

Khalaf, Ahmed and de Beauchamp, Lucie and Kalkman, Eric and Rattigan, Kevin and Himonas, Ekaterini and Jones, Joe and James, Daniel and Shokry, Engy Shokry Abd and Scott, Mary T. and Dunn, Karen and Tardito, Saverio and Copland, Mhairi and Sumpton, David and Shanks, Emma and Helgason, Vignir (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16 (751): eadi5336. ISSN 1946-6234

Zarou, Martha M. and Rattigan, Kevin M. and Sarnello, Daniele and Shokry, Engy and Dawson, Amy and Ianniciello, Angela and Dunn, Karen and Copland, Mhairi and Sumpton, David and Vazquez, Alexei and Helgason, Vignir (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15: 1931. ISSN 2041-1723

Dawson, Amy and Zarou, Martha M. and Prasad, Bodhayan and Bittencourt-Silvestre, Joana and Zerbst, Désirée and Himonas, Ekaterini and Hsieh, Ya-Ching and van Loon, Isabel and Rodriguez Blanco, Giovanny and Ianniciello, Angela and Kerekes, Zsombor and Krishnan, Vaidehi and Agarwal, Puneet and Almasoudi, Hassan and McCluskey, Laura and Hopcroft, Lisa E.M. and Scott, Mary T. and Baquero, Pablo and Dunn, Karen and Vetrie, David and Copland, Mhairi and Bhatia, Ravi and Coffelt, Seth B. and Tiong, Ong Sin and Wheadon, Helen and Zanivan, Sara and Kirschner, Kristina and Helgason, G. Vignir (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15: 1090. ISSN 2041-1723

See full publications list
Shokry, Engy
Author

Zarou, Martha M. and Rattigan, Kevin M. and Sarnello, Daniele and Shokry, Engy and Dawson, Amy and Ianniciello, Angela and Dunn, Karen and Copland, Mhairi and Sumpton, David and Vazquez, Alexei and Helgason, Vignir (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15: 1931. ISSN 2041-1723

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

See full publications list
Sumpton, David
Author

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

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Copland, Mhairi
Author

Copland, Mhairi (2024) Triplet therapy for advanced BCR::ABL1 positive myeloid leukaemias. Lancet Haematology, 11 (11). e807-e808. ISSN 2352-3026

Innes, Andrew I. and Hayden, Chloe and Orovbon, Victoria and Claudiani, Simone and Fernando, Fiona and Khan, Afzal and Rees, David and Byrne, Jennifer and Gallipoli, Paolo and Francis, Sebastian and Copland, Mhairi and Horne, Gillian and Raghavan, Manoj and Arnold, Claire and Collins, Angela and Cranfield, Tanya and Cunningham, Nicholas and Danga, Akila and Forsythe, Peter and Frewin, Rebecca and Garland, Paula and Hannah, Guy and Avenoso, Daniele and Hassan, Sandra and Huntly, Brian J.P. and Husain, Jissan and Makkuni, Sudhakaran and Rothwell, Kate and Khorashad, Jamshid and Apperley, Jane F. and Milojkovic, Dragana (2024) Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy. Leukemia, 38 (11). pp. 2443-2455. ISSN 0887-6924

Khalaf, Ahmed and de Beauchamp, Lucie and Kalkman, Eric and Rattigan, Kevin and Himonas, Ekaterini and Jones, Joe and James, Daniel and Shokry, Engy Shokry Abd and Scott, Mary T. and Dunn, Karen and Tardito, Saverio and Copland, Mhairi and Sumpton, David and Shanks, Emma and Helgason, Vignir (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16 (751): eadi5336. ISSN 1946-6234

See full publications list
Tardito, Saverio
Author

Khalaf, Ahmed and de Beauchamp, Lucie and Kalkman, Eric and Rattigan, Kevin and Himonas, Ekaterini and Jones, Joe and James, Daniel and Shokry, Engy Shokry Abd and Scott, Mary T. and Dunn, Karen and Tardito, Saverio and Copland, Mhairi and Sumpton, David and Shanks, Emma and Helgason, Vignir (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16 (751): eadi5336. ISSN 1946-6234

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

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Vande Voorde, Johan
Author

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

See full publications list
Mussai, Francis
Author

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

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Cheng, Paul
Author

Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24: e56279. ISSN 1469-221X

See full publications list
Helgason, G. Vignir
Author

Khalaf, Ahmed and de Beauchamp, Lucie and Kalkman, Eric and Rattigan, Kevin and Himonas, Ekaterini and Jones, Joe and James, Daniel and Shokry, Engy Shokry Abd and Scott, Mary T. and Dunn, Karen and Tardito, Saverio and Copland, Mhairi and Sumpton, David and Shanks, Emma and Helgason, Vignir (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16 (751): eadi5336. ISSN 1946-6234

Zarou, Martha M. and Rattigan, Kevin M. and Sarnello, Daniele and Shokry, Engy and Dawson, Amy and Ianniciello, Angela and Dunn, Karen and Copland, Mhairi and Sumpton, David and Vazquez, Alexei and Helgason, Vignir (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15: 1931. ISSN 2041-1723

Dawson, Amy and Zarou, Martha M. and Prasad, Bodhayan and Bittencourt-Silvestre, Joana and Zerbst, Désirée and Himonas, Ekaterini and Hsieh, Ya-Ching and van Loon, Isabel and Rodriguez Blanco, Giovanny and Ianniciello, Angela and Kerekes, Zsombor and Krishnan, Vaidehi and Agarwal, Puneet and Almasoudi, Hassan and McCluskey, Laura and Hopcroft, Lisa E.M. and Scott, Mary T. and Baquero, Pablo and Dunn, Karen and Vetrie, David and Copland, Mhairi and Bhatia, Ravi and Coffelt, Seth B. and Tiong, Ong Sin and Wheadon, Helen and Zanivan, Sara and Kirschner, Kristina and Helgason, G. Vignir (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15: 1090. ISSN 2041-1723

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Title:
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
Creators:
Rattigan, Kevin M. and Zarou, Martha M. and Brabcova, Zuzana and Prasad, Bodhayan and Zerbst, Désirée and Sarnello, Daniele and Kalkman, Eric R. and Ianniciello, Angela and Scott, Mary T. and Dunn, Karen and Shokry, Engy and Sumpton, David and Copland, Mhairi and Tardito, Saverio and Vande Voorde, Johan and Mussai, Francis and Cheng, Paul and Helgason, G. Vignir
Identification Number:
10.15252/embr.202256279
Date:
9 October 2023
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:
EMBO Press
Additional Information:
The authors thank the Core Services and Advanced Technologies at the Cancer Research UK Beatson Institute (C596/A17196; A31287). This work was supported by The Kay Kendall Leukaemia Fund (KKL1069), Blood Cancer UK (formerly Bloodwise; Ref 18006), Cancer Research UK (C57352/A29754), Cancer Research UK Glasgow Centre (A25142), The Howat Foundation, Tenovus Scotland and Friends of Paul O'Gorman Leukaemia Research Centre (all to GVH); NHS-GGC Endowment Fellowship (GN17ON425) to KMR; and Cancer Research UK to DS and ST (A23982).
Library
URI:
https://pub.demo35.eprints-hosting.org/id/eprint/487
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
Date Deposited:
11 Jun 2025 16:38
Revision:
43
Last Modified:
12 Jun 2025 09:16
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