Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

Abstract

Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3. Here we find that MOMP occurring in a subset of mitochondria is a feature of cellular senescence. This process, called minority MOMP (miMOMP), requires BAX and BAK macropores enabling the release of mitochondrial DNA (mtDNA) into the cytosol. Cytosolic mtDNA in turn activates the cGAS–STING pathway, a major regulator of the SASP. We find that inhibition of MOMP in vivo decreases inflammatory markers and improves healthspan in aged mice. Our results reveal that apoptosis and senescence are regulated by similar mitochondria-dependent mechanisms and that sublethal mitochondrial apoptotic stress is a major driver of the SASP. We provide proof-of-concept that inhibition of miMOMP-induced inflammation may be a therapeutic route to improve healthspan.

People
Victorelli, Stella
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Salmonowicz, Hanna
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Chapman, James
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Martini, Helene
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Vizioli, Maria Grazia
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Riley, Joel S.
Author

von Mässenhausen, Anne and Schlecht, Marlena Nastassja and Beer, Kristina and Maremonti, Francesca and Tonnus, Wulf and Belavgeni, Alexia and Gavali, Shubhangi and Flade, Karolin and Riley, Joel S. and Zamora Gonzalez, Nadia and Brucker, Anne and Becker, Jorunn Naila and Tmava, Mirela and Meyer, Claudia and Peitzsch, Mirko and Hugo, Christian and Gembardt, Florian and Angeli, Jose Pedro Friedmann and Bornstein, Stefan R. and Tait, Stephen W. G. and Linkermann, Andreas (2024) Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis. Science Advances, 10 (11): eadk7329. ISSN 2375-2548

Vringer, Esmee and Heilig, Rosalie and Riley, Joel S. and Black, Annabel and Cloix, Catherine and Skalka, George and Montes-Gómez, Alfredo E. and Aguado, Aurore and Lilla, Sergio and Walczak, Henning and Gyrd-Hansen, Mads and Murphy, Daniel J. and Huang, Danny T. and Zanivan, Sara and Tait, Stephen W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43 (6). pp. 904-930. ISSN 0261-4189

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Cloix, Catherine
Author

Vringer, Esmee and Heilig, Rosalie and Riley, Joel S. and Black, Annabel and Cloix, Catherine and Skalka, George and Montes-Gómez, Alfredo E. and Aguado, Aurore and Lilla, Sergio and Walczak, Henning and Gyrd-Hansen, Mads and Murphy, Daniel J. and Huang, Danny T. and Zanivan, Sara and Tait, Stephen W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43 (6). pp. 904-930. ISSN 0261-4189

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Hall-Younger, Ella
Author

Hall-Younger, Ella and Tait, Stephen W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94: 102510. ISSN 0955-0674

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Espindola-Netto, Jair Machado
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Jurk, Diana
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Lagnado, Anthony B.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Gomez, Lilian Sales
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Farr, Joshua N.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Saul, Dominik
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Reed, Rebecca
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Kelly, George
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Eppard, Madeline
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Greaves, Laura C.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Dou, Zhixun
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Pirius, Nicholas
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Szczepanowska, Karolina
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Porritt, Rebecca A.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Huang, Huijie
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Huang, Timothy Y.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Mann, Derek A.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Masuda, Claudio Akio
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Khosla, Sundeep
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Dai, Haiming
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Kaufmann, Scott H.
Author

Vincelette, Nicole D. and Yu, Xiaoqing and Kuykendall, Andrew T. and Moon, Jungwon and Su, Siyuan and Cheng, Chia- Ho and Sammut, Rinzine and Razabdouski, Tiffany N. and Nguyen, Hai Vu and Eksioglu, Erika A. and Chan, Onyee and Al Ali, Najla and Patel, Parth C. and Lee, Dae Hyun and Nakanishi, Shima and Ferreira, Renan B. and Mo, Qianxing and Cory, Suzanne and Lawrence, Harshani R. and Zhang, Ling and Murphy, Daniel J. and Komrokji, Rami S. and Lee, Daesung and Kaufmann, Scott H. and Cleveland, John L. and Yun, Seongseok (2024) Trisomy 8 defines a distinct subtype of myeloproliferative neoplasms driven by the MYC-alarmin axis. Blood Cancer Discovery, 5 (4). pp. 276-297. ISSN 2643-3230

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Zacharioudakis, Emmanouil
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Gavathiotis, Evripidis
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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LeBrasseur, Nathan K.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Lei, Xue
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Sainz, Alva G.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Korolchuk, Viktor I.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Adams, Peter D.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Shadel, Gerald S.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Tait, Stephen W.G.
Author

Hall-Younger, Ella and Tait, Stephen W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94: 102510. ISSN 0955-0674

Ahmed Hassan Elshiekh, Asma and Tait, Stephen W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18 (5). pp. 1054-1057. ISSN 1574-7891

Vringer, Esmee and Heilig, Rosalie and Riley, Joel S. and Black, Annabel and Cloix, Catherine and Skalka, George and Montes-Gómez, Alfredo E. and Aguado, Aurore and Lilla, Sergio and Walczak, Henning and Gyrd-Hansen, Mads and Murphy, Daniel J. and Huang, Danny T. and Zanivan, Sara and Tait, Stephen W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43 (6). pp. 904-930. ISSN 0261-4189

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Passos, João F.
Author

Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F. (2023) Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature, 622 (7983). pp. 627-636. ISSN 0028-0836

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Title:
Apoptotic stress causes mtDNA release during senescence and drives the SASP
Creators:
Victorelli, Stella and Salmonowicz, Hanna and Chapman, James and Martini, Helene and Vizioli, Maria Grazia and Riley, Joel S. and Cloix, Catherine and Hall-Younger, Ella and Espindola-Netto, Jair Machado and Jurk, Diana and Lagnado, Anthony B. and Gomez, Lilian Sales and Farr, Joshua N. and Saul, Dominik and Reed, Rebecca and Kelly, George and Eppard, Madeline and Greaves, Laura C. and Dou, Zhixun and Pirius, Nicholas and Szczepanowska, Karolina and Porritt, Rebecca A. and Huang, Huijie and Huang, Timothy Y. and Mann, Derek A. and Masuda, Claudio Akio and Khosla, Sundeep and Dai, Haiming and Kaufmann, Scott H. and Zacharioudakis, Emmanouil and Gavathiotis, Evripidis and LeBrasseur, Nathan K. and Lei, Xue and Sainz, Alva G. and Korolchuk, Viktor I. and Adams, Peter D. and Shadel, Gerald S. and Tait, Stephen W.G. and Passos, João F.
Identification Number:
10.1038/s41586-023-06621-4
Date:
19 October 2023
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:
Nature Research
Additional Information:
This work was funded by NIH grants R01AG068048 (JFP); UG3CA268103 (JFP); P01 AG062413 (SK, JNF, NKL, JFP), P01 AG073084 and R01 AR069876 (GSS), F31 AG062099 (AGS), R01 AG068182-01 (DJ), R01 CA225996 (SHK and HD), R01 DK128552 (JNF), R01 AG071861-01 (XL, PDA), P01 AG073084 (PDA, XL), R01 AG076515 (SK), R01 AG061875 and RF1 AG070391 (TYH), R01AG071861 (PDA), Department of Defense grant W81XWH-20-1-0792 (EG), U54 AG79754 (SK, NKL), Cancer Research UK grants C40872/A2014, DRCNPG-Jun22\100011 (S.W.G.T), the Ted Nash long life foundation (JFP, DJ), The Glenn Foundation For Medical Research (JFP, NKL), Hevolution/AFAR (DJ), a Robert and Arlene Kogod Center on Aging Career Development Award (SGV), a fellowship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (Capes)—Finance Code 001 and by the Universidade Federal do Rio de Janeiro (CAM). BBSRC PhD studentship BB/R506345/1 (GK, VIK). CRUK Awards C18342/A23390 and DRCRPG-Nov22/100007, and MRC MR/R023026/1 (DAM). GSS holds the Audrey Geisel Chair in Biomedical Science. MS interactome analysis was done at the Proteomic Core Facility of IMol Polish Academy of Sciences and supported by ReMedy International Research Agenda (Foundation of Polish Science, MAB/2017/2) and EMBO Installation Grant 5040-2022 (KS).
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URI:
https://pub.demo35.eprints-hosting.org/id/eprint/482
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
Date Deposited:
11 Jun 2025 16:38
Revision:
82
Last Modified:
12 Jun 2025 09:43
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