EPrints - Publications Repository

Vasan, Richa and Yadav, Jahnavi and Aiyappa‐Maudsley, Radhika and Deen, Suha and Storr, Sarah and Martin, Stewart (2023) High BMP7 expression is associated with poor prognosis in ovarian cancer. Journal of Cellular and Molecular Medicine, 27 (21). pp. 3378-3387. ISSN 1582-1838

AI Summary:

The study aimed to assess BMP7 protein expression in ovarian carcinoma patient tumour samples. The results showed that high BMP7 expression was associated with aggressive clinicopathological variables, including advanced FIGO stage, high grade, residual disease and poor overall survival.

AI Topics:

The following topics are generate through an AI service. Clicking on them will take you to a search result page with related items.

Abstract

Bone Morphogenetic Protein 7 (BMP7) is an extracellular signalling protein that belongs to the transforming growth factor-β (TGF- β) superfamily. Previous transcriptomic data suggested that BMP7 expression may be disrupted in ovarian carcinoma and may play an important role in the aggressiveness of the disease. However, the protein expression in patient tumours has not been well studied. The current study aimed to assess BMP7 protein expression in a large cohort of ovarian carcinoma patient tumour samples to establish its associations with different clinical endpoints. Ovarian carcinoma tissue samples from 575 patients who underwent surgery for different subtypes of ovarian cancer were used. BMP7 protein expression was analysed by immunohistochemistry using tissue microarray and full face tumour sections. High BMP7 expression is associated with aggressive ovarian cancer clinicopathological variables including advanced FIGO stage, high grade, residual disease and poor overall survival. Elevated cytoplasmic and nuclear BMP7 expression was significantly associated with advanced FIGO stage, high tumour grade, presence of residual tumours and high-grade serous carcinomas (p = 0.001, 0.005, 0.004, <0.001 and p < 0.001, <0.001, 0.002, 0.001 respectively). Increased cytoplasmic and nuclear BMP7 expression was also significantly associated with an adverse overall survival (p = 0.001 and 0.046 respectively). The study highlights the potential of BMP7 as a prognostic tool and as a potential novel target for ovarian cancer therapies to limit disease progression.

People

Vasan, Richa

Author

Publications

Saidy, Behnaz and Vasan, Richa and Durant, Rosie and Greener, Megan-Rose and Immanuel, Adelynn and Green, Andrew R. and Rakha, Emad and Ellis, Ian and Ball, Graham and Martin, Stewart G. and Storr, Sarah J. (2023) Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways. Scientific Reports, 13: 21163. ISSN 2045-2322