Taggart, Ruairidh and Dutto, Lorenzo and Leung, Hing Y. and Salji, Mark and Ahmad, Imran (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP). Cancer Medicine, 12 (22). pp. 20830-20837. ISSN 2045-7634
AI Summary:
The study analyzed 1223 robotic-assisted laparoscopic prostatectomy (RALP) cases. The results showed that many patients who met CPG1 or EAU low-risk criteria were upgraded post-RALP and approximately 25% were upstaged due to extraprostatic disease.AI Topics:
Background:
Risk of biochemical recurrence (BCR) in localised prostate cancer can be stratified using the 5-tier Cambridge Prognostic Group (CPG) or 3-tier European Association of Urology (EAU) model. Active surveillance is the current recommendation if CPG1 or EAU low-risk criteria are met. We aimed to determine the contemporary rates of upgrading, upstaging and BCR after radical prostatectomy for CPG1 or EAU low-risk disease.
Methods:
A database of all robotic-assisted laparoscopic prostatectomies (RALPs) performed in Glasgow between 12/2015 and 05/2022 was analysed. Rates of upgrading, upstaging and BCR post-RALP for CPG1 or EAU low-risk disease were defined. Univariate and multivariate analysis were performed to assess the relationship between patient factors and outcomes.
Results:
A total of 1223 RALP cases were identified. A total of 12.6% met CPG1 criteria with 70.1% and 25.3% upgraded and upstaged to extraprostatic disease post-operatively respectively. A total of 5.8% met EAU low-risk criteria with 60.6% upgraded and 25.4% upstaged to extraprostatic disease post-operatively respectively. CPG1 (p < 0.0001) and EAU low-risk (p = 0.02) patients were at a significantly higher risk of BCR if upstaged.
Discussion:
Many patients who met CPG1 or EAU low-risk criteria were upgraded post-RALP and approximately 25% were upstaged due to extraprostatic disease. Upstaging puts patients at a significantly higher risk of BCR.
Taggart, Ruairidh
Author
Taggart, Ruairidh and Dutto, Lorenzo and Leung, Hing Y. and Salji, Mark and Ahmad, Imran (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP). Cancer Medicine, 12 (22). pp. 20830-20837. ISSN 2045-7634
See full publications listDutto, Lorenzo
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
Taggart, Ruairidh and Dutto, Lorenzo and Leung, Hing Y. and Salji, Mark and Ahmad, Imran (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP). Cancer Medicine, 12 (22). pp. 20830-20837. ISSN 2045-7634
See full publications listLeung, Hing Y.
Author
Sahni, Dhruv Satya and Morrison, John and Leung, Hing Y. (2024) Grid-based cognitive diagnostic prostatic biopsies without transrectal ultrasound imaging. BJU International, 134 (4). pp. 659-663. ISSN 1464-4096
Taggart, Ruairidh and Dutto, Lorenzo and Leung, Hing Y. and Salji, Mark and Ahmad, Imran (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP). Cancer Medicine, 12 (22). pp. 20830-20837. ISSN 2045-7634
See full publications listSalji, Mark
Author
Taggart, Ruairidh and Dutto, Lorenzo and Leung, Hing Y. and Salji, Mark and Ahmad, Imran (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP). Cancer Medicine, 12 (22). pp. 20830-20837. ISSN 2045-7634
See full publications listAhmad, Imran
Author
Ibrahim, Ibrahim and Kouli, Omar and Ilangovan, Sanjana and Sneddon, Melanie and Nalagatla, Sarika and Marshall, Carol and Dutto, Lorenzo and Leung, Hing Y. and Ahmad, Imran (2025) Impact of centralisation of radical prostatectomy driven by the introduction of robotic systems on positive surgical margin and biochemical recurrence in pT2 prostate cancer. Cancer Medicine, 14 (2): e70514. ISSN 2045-7634
Mariappan, Paramananthan and Johnston, Allan and Trail, Matthew and Hamid, Sami and Hollins, Graham and Dreyer, Barend A and Ramsey, Sara and Padovani, Luisa and Garau, Roberta and Enriquez, Julia Guerrero and Boden, Alasdair and Maresca, Gianluca and Simpson, Helen and Hasan, Rami and Sharpe, Claire and Thomas, Benjamin G. and Chaudhry, Altaf H. and Khan, Rehan S. and Bhatt, Jaimin R. and Ahmad, Imran and Nandwani, Ghulam M and Dimitropoulos, Konstantinos and Makaroff, Lydia and Shaw, Johnstone and Graham, Catriona and Hendry, David (2024) Achieving benchmarks for national quality indicators reduces recurrence and progression in non-muscle-invasive bladder cancer. European Urology Oncology, 7 (6). pp. 1327-1337. ISSN 2588-9311
Taggart, Ruairidh and Dutto, Lorenzo and Leung, Hing Y. and Salji, Mark and Ahmad, Imran (2023) A contemporary analysis of disease upstaging of Gleason 3+3 prostate cancer patients after Robot-Assisted Laparoscopic Prostatectomy (RALP). Cancer Medicine, 12 (22). pp. 20830-20837. ISSN 2045-7634
See full publications listAvailable under License Creative Commons Attribution.
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