Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
AI Summary:
This study reports an analytical approach to the largest multi-parameter immunoprofiling study of clinical trial samples to date. The authors developed an adaptive thresholding method to account for inter- and intra-slide intensity variation in TMA analysis.AI Topics:
Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers for tumour immunoprofiling. However, application at scale to clinical trial samples sourced from multiple institutions is challenging due to pre-analytical heterogeneity. This study reports an analytical approach to the largest multi-parameter immunoprofiling study of clinical trial samples to date. We analysed 12,592 tissue microarray (TMA) spots from 3,545 colorectal cancers sourced from more than 240 institutions in two clinical trials (QUASAR 2 and SCOT) stained for CD4, CD8, CD20, CD68, FoxP3, pan-cytokeratin, and DAPI by mIF. TMA slides were multi-spectrally imaged and analysed by cell-based and pixel-based marker analysis. We developed an adaptive thresholding method to account for inter- and intra-slide intensity variation in TMA analysis. Applying this method effectively ameliorated inter- and intra-slide intensity variation improving the image analysis results compared with methods using a single global threshold. Correlation of CD8 data derived by our mIF analysis approach with single-plex chromogenic immunohistochemistry CD8 data derived from subsequent sections indicates the validity of our method (Spearman's rank correlation coefficients ρ between 0.63 and 0.66, p ≪ 0.01) as compared with the current gold standard analysis approach. Evaluation of correlation between cell-based and pixel-based analysis results confirms equivalency (ρ > 0.8, p ≪ 0.01, except for CD20 in the epithelial region) of both analytical approaches. These data suggest that our adaptive thresholding approach can enable analysis of mIF-stained clinical trial TMA datasets by digital pathology at scale for precision immunoprofiling.
Frei, Anja L.
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listMcGuigan, Anthony
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listSinha, Ritik RAK
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listGlaire, Mark A.
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listJabbar, Faiz
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listGneo, Luciana
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listTomasevic, Tijana
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listHarkin, Andrea
Author
Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966
Lemanska, A. and Harkin, Andrea and Iveson, T. and Kelly, Caroline and Saunders, M. and Faithfull, S. (2023) The association of clinical and patient factors with chemotherapy-induced peripheral neuropathy (CIPN) in colorectal cancer: secondary analysis of the SCOT trial. ESMO Open, 8 (6): 102063. ISSN 2059-7029
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listIveson, Tim J.
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listSaunders, Mark
Author
Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listOein, Karin
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listMaka, Noori
Author
Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377
Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X
Galbraith, Norman J. and Quinn, Jean A. and Al-Badran, Sara Sf and Pennel, Kathryn A.F. and Hillson, Lily V.S. and Hatthakarnkul, Phimmada and McKenzie, Molly and Maka, Noori and Loi, Lynette and Frixou, Mikaela and Steele, Colin W. and Roxburgh, Campbell S. and Horgan, Paul G. and McMillan, Donald C. and Edwards, Joanne (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48: 102064. ISSN 1944-7124
See full publications listPezella, Francesco
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listCampo, Leticia
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listHay, J.
Author
Fullerton, Josie L. and Hay, Jennifer and Bryant-Craig, Charlotte and Atkinson, Josephine and Smith, Douglas H. and Stewart, William (2024) Pediatric traumatic brain injury and microvascular blood-brain barrier pathology. JAMA Network Open, 7 (11): e2446767. ISSN 2574-3805
Knight, Katrina and Bigley, Christopher and Pennel, Kathryn and Hay, Jennifer and Maka, Noori and McMillan, Donald and Park, James and Roxburgh, Campbell and Edwards, Joanne (2024) The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer. Journal of Pathology: Clinical Research, 10: e12385. ISSN 2056-4538
Hatthakarnkul, Phimmada and Pennel, Kathryn and Alexander, Peter and Van Wyk, Hester and Roseweir, Antonia and Inthagard, Jitwadee and Hay, Jennifer and Andersen, Ditte and Maka, Noori and Park, James and Roxburgh, Campbell and Thuwajit, Chanitra and McMillan, Donald and Edwards, Joanne (2024) Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 10 (3): e12374. ISSN 2056-4538
See full publications listEdwards, J.
Author
Thompson, Joshua J. and MacLeod, Nicholas and Will, Sarah and O'Rourke, Fraser and McGovern, Josh and Roxburgh, Campbell and Edwards, Joanne and Dolan, Ross D. and McMillan, Donald C. (2025) The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. BMC Cancer, 25: 543. ISSN 1471-2407
Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377
Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X
See full publications listSansom, Owen
Author
Lu, Yuting and Travnickova, Jana and Badonyi, Mihaly and Rambow, Florian and Coates, Andrea and Khan, Zaid and Marques, Jair and Murphy, Laura C. and Garcia-Martinez, Pablo and Marais, Richard and Louphrasitthiphol, Pakavarin and Chan, Alex H.Y. and Schofield, Christopher J. and von Kriegsheim, Alex and Marsh, Joseph A. and Pavet, Valeria and Sansom, Owen J. and Illingworth, Robert S. and Patton, E. Elizabeth (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports, 43 (7): 114406. ISSN 2639-1856
Pereira, Brooke A. and Ritchie, Shona and Chambers, Cecilia R. and Gordon, Katie A. and Magenau, Astrid and Murphy, Kendelle J. and Nobis, Max and Tyma, Victoria M. and Liew, Ying Fei and Lucas, Morghan C. and Naeini, Marjan M. and Barkauskas, Deborah S. and Chacon-Fajardo, Diego and Howell, Anna E. and Parker, Amelia L. and Warren, Sean C. and Reed, Daniel A. and Lee, Victoria and Metcalf, Xanthe L. and Lee, Young Kyung and O'Regan, Luke P. and Zhu, Jessie and Trpceski, Michael and Fontaine, Angela R.M. and Stoehr, Janett and Rouet, Romain and Lin, Xufeng and Chitty, Jessica L. and Porazinski, Sean and Wu, Sunny Z. and Filipe, Elysse C. and Cadell, Antonia L. and Holliday, Holly and Yang, Jessica and Papanicolaou, Michael and Lyons, Ruth J. and Zaratzian, Anaiis and Tayao, Michael and Da Silva, Andrew and Vennin, Claire and Yin, Julia and Dew, Alysha B. and McMillan, Paul J. and Goldstein, Leonard D. and Deveson, Ira W. and Croucher, David R. and Samuel, Michael S. and Sim, Hao-Wen and Batten, Marcel and Chantrill, Lorraine and Grimmond, Sean M. and Gill, Anthony J. and Samra, Jaswinder and Evans, Thomas R. Jeffry and Sasaki, Takako and Phan, Tri G. and Swarbrick, Alexander and Sansom, Owen J. and Morton, Jennifer P. and Australian Pancreatic Cancer Matrix Atlas (APMA) and Australian Pancreatic Cancer Genome Initiative (APGI) and Pajic, Marina and Parker, Benjamin L. and Herrmann, David and Cox, Thomas R. and Timpson, Paul (2024) Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science Advances, 10 (27): eadl1197. ISSN 2375-2548
Malla, Sudhir B. and Byrne, Ryan M. and Lafarge, Maxime W. and Corry, Shania M. and Fisher, Natalie C. and Tsantoulis, Petros K. and Mills, Megan L. and Ridgway, Rachel A. and Lannagan, Tamsin R. M. and Najumudeen, Arafath K. and Gilroy, Kathryn L. and Amirkhah, Raheleh and Maguire, Sarah L. and Mulholland, Eoghan J. and Belnoue-Davis, Hayley L. and Grassi, Elena and Viviani, Marco and Rogan, Emily and Redmond, Keara L. and Sakhnevych, Svetlana and McCooey, Aoife J. and Bull, Courtney and Hoey, Emily and Sinevici, Nicoleta and Hall, Holly and Ahmaderaghi, Baharak and Domingo, Enric and Blake, Andrew and Richman, Susan D. and Isella, Claudio and Miller, Crispin and Bertotti, Andrea and Trusolino, Livio and Loughrey, Maurice B. and Kerr, Emma M. and Tejpar, Sabine and S:CORT Consortium and Maughan, Timothy S. and Lawler, Mark and Campbell, Andrew D. and Leedham, Simon J. and Koelzer, Viktor H. and Sansom, Owen J. and Dunne, Philip D. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56 (6): 1321. ISSN 1061-4036
See full publications listKelly, Caroline
Author
Derby, Sarah and Jackson, Mark R. and Williams, Karin and Stobo, Jamie and Kelly, Caroline and Sweeting, Lorna and Shad, Shumaila and Herbert, Christopher and Short, Susan C. and Williamson, Aoife and James, Allan and Nowicki, Stefan and Bulbeck, Helen and Chalmers, Anthony (2024) Concurrent olaparib and radiotherapy in elderly patients with newly diagnosed glioblastoma: the phase I dose escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118 (5). pp. 1371-1378. ISSN 0360-3016
Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
See full publications listTomlinson, Ian
Author
Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listKildal, Wanja
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listKerr, Rachel S.
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listKerr, David J.
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listDanielsen, Håvard E.
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listDomingo, Enric
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listChurch, David N.
Author
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listKoelzer, Viktor H.
Author
Malla, Sudhir B. and Byrne, Ryan M. and Lafarge, Maxime W. and Corry, Shania M. and Fisher, Natalie C. and Tsantoulis, Petros K. and Mills, Megan L. and Ridgway, Rachel A. and Lannagan, Tamsin R. M. and Najumudeen, Arafath K. and Gilroy, Kathryn L. and Amirkhah, Raheleh and Maguire, Sarah L. and Mulholland, Eoghan J. and Belnoue-Davis, Hayley L. and Grassi, Elena and Viviani, Marco and Rogan, Emily and Redmond, Keara L. and Sakhnevych, Svetlana and McCooey, Aoife J. and Bull, Courtney and Hoey, Emily and Sinevici, Nicoleta and Hall, Holly and Ahmaderaghi, Baharak and Domingo, Enric and Blake, Andrew and Richman, Susan D. and Isella, Claudio and Miller, Crispin and Bertotti, Andrea and Trusolino, Livio and Loughrey, Maurice B. and Kerr, Emma M. and Tejpar, Sabine and S:CORT Consortium and Maughan, Timothy S. and Lawler, Mark and Campbell, Andrew D. and Leedham, Simon J. and Koelzer, Viktor H. and Sansom, Owen J. and Dunne, Philip D. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56 (6): 1321. ISSN 1061-4036
Malla, Sudhir B. and Byrne, Ryan M. and Lafarge, Maxime W. and Corry, Shania M. and Fisher, Natalie C. and Tsantoulis, Petros K. and Mills, Megan L. and Ridgway, Rachel A. and Lannagan, Tamsin R. M. and Najumudeen, Arafath K. and Gilroy, Kathryn L. and Amirkhah, Raheleh and Maguire, Sarah L. and Mulholland, Eoghan J. and Belnoue-Davis, Hayley L. and Grassi, Elena and Viviani, Marco and Rogan, Emily and Redmond, Keara L. and Sakhnevych, Svetlana and McCooey, Aoife J. and Bull, Courtney and Hoey, Emily and Sinevici, Nicoleta and Hall, Holly and Ahmaderaghi, Baharak and Domingo, Enric and Blake, Andrew and Richman, Susan D. and Isella, Claudio and Miller, Crispin and Bertotti, Andrea and Trusolino, Livio and Loughrey, Maurice B. and Kerr, Emma M. and Tejpar, Sabine and S:CORT consortium and Maughan, Timothy S. and Lawler, Mark and Campbell, Andrew D. and Leedham, Simon J. and Koelzer, Viktor H. and Sansom, Owen J. and Dunne, Philip D. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56 (3). pp. 458-472. ISSN 1061-4036
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538
See full publications listAvailable under License Creative Commons Attribution.
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