Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

Abstract

Objectives: To report the NHS Digital (NHSD) data for patients diagnosed with kidney cancer (KC) in England. We explore the incidence, route to diagnosis (RTD), treatment, and survival patterns from 2013 to 2019. Materials and Methods: Data was extracted from the Cancer Data NHSD portal for International Classification of Diseases, 10th edition coded KC; this included Cancer Registry data, Hospital Episode Statistics, and cancer waiting times data. Results: Registrations included 66 696 individuals with KC. Incidence of new KC diagnoses increased (8998 in 2013, to 10 232 in 2019), but the age‐standardised rates were stable (18.7–19.4/100 000 population). Almost half of patients (30 340 [45.5%]) were aged 0–70 years and the cohort were most frequently diagnosed with Stage 1–2 KC (n = 26 297 [39.4%]). Most patients were diagnosed through non‐urgent general practitioner referrals (n = 16 814 [30.4%]), followed by 2‐week‐wait (n = 15 472 [28.0%]) and emergency routes (n = 11 796 [21.3%]), with older patients (aged ≥70 years), Stage 4 KCs, and patients with non‐specified renal cell carcinoma being significantly more likely to present through the emergency route (all P < 0.001). Invasive treatment (surgery or ablation), radiotherapy, or systemic anti‐cancer therapy use varied with disease stage, patient factors, and treatment network (Cancer Alliance). Survival outcomes differed by Stage, histological subtype, and social deprivation class (P < 0.001). Age‐standardised mortality rates did not change over the study duration, although immunotherapy usage is likely not captured in this study timeline. Conclusion: The NHSD resource provides useful insight about the incidence, diagnostic pathways, treatment, and survival of patients with KC in England and a useful benchmark for the upcoming commissioned National Kidney Cancer Audit. The RTD data may be limited by incidental diagnoses, which could confound the high proportion of ‘emergency’ diagnoses. Importantly, survival outcomes remained relatively unchanged.

People
Conroy, Samantha
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Catto, James W.F.
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Bex, Axel
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Brown, Janet E.
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Cartledge, Jon
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Fielding, Alison
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Jones, Robert
Author

Elyan, Benjamin M.P. and Tan, Beatrix and Lambourg, Emilie and McAllister, David A. and Jones, Rob J. and Lang, Ninian N. and Mark, Patrick B. and Lees, Jennifer S. and Bell, Samira (2025) Incidence of cancer in people with CKD not requiring kidney replacement therapy: a systematic review and meta-analysis. Clinical Kidney Journal, 18 (5): sfaf084. ISSN 2048-8505

Elyan, Benjamin M.P. and Sullivan, Michael K. and Hedley, James and De La Mata, Nicole and Webster, Angela C. and Venugopal, Balaji and Jones, Rob J. and Lang, Ninian N. and Mark, Patrick B. and Lees, Jennifer S. (2024) The impact of VEGF signalling pathway inhibitors and/or immune checkpoint inhibitors on kidney function over time: a single centre retrospective analysis. BJC Reports, 2: 57. ISSN 2731-9377

Rescigno, Pasquale and Porta, Nuria and Finneran, Laura and Riisnaes, Ruth and Figueiredo, Ines and Carreira, Suzanne and Flohr, Penny and Miranda, Susana and Bertan, Claudia and Ferreira, Ana and Crespo, Mateus and Rodrigues, Daniel Nava and Gurel, Bora and Nobes, Jenny and Crabb, Simon and Malik, Zafar and Ralph, Christy and McGovern, Ursula and Hoskin, Peter and Jones, Robert J. and Birtle, Alison and Gale, Joanna and Sankey, Peter and Jain, Suneil and McLaren, Duncan and Chadwick, Eliot and Espinasse, Aude and Hall, Emma and de Bono, Johann (2024) Capivasertib in combination with enzalutamide for metastatic castration resistant prostate cancer after docetaxel and abiraterone: Results from the randomized phase II RE-AKT trial. European Journal of Cancer, 205: 114103. ISSN 0959-8049

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Khoo, Vincent
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Nicol, David
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Stewart, Grant D.
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Sullivan, Mark
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Tran, Maxine G.B.
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Woodward, Rose
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Cumberbatch, Marcus G.
Author

Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G. (2023) Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019. BJU International, 132 (5). pp. 541-553. ISSN 1464-4096

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Title:
Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019
Creators:
Conroy, Samantha and Catto, James W.F. and Bex, Axel and Brown, Janet E. and Cartledge, Jon and Fielding, Alison and Jones, Rob J. and Khoo, Vincent and Nicol, David and Stewart, Grant D. and Sullivan, Mark and Tran, Maxine G.B. and Woodward, Rose and Cumberbatch, Marcus G.
Identification Number:
10.1111/bju.16128
Date:
November 2023
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:
Wiley
Additional Information:
This study was supported by the Yorkshire Cancer Research UK (Grant number RA/2019/R1/004). Samantha Conroy has received charitable research funding from The Urology Foundation (2020/21 and 2022/23) and is recipient of the Royal College of Surgeon's 1-year Research Fellowship (2022/23). James W.F. Catto is funded by a Research Professorship from the National Institute for Health and Care Research (NIHR). Rob J. Jones has received grant funding from Exelixis and Roche. Maxine G.B. Tran has received research funding from GSK. Janet E. Brown has received research funding paid to their institution from the NIHR. Vincent Khoo had received research funding paid to their institution for Cancer Research UK (CRUK). Axel Bex received research funding paid to their institution from Pfizer.
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https://pub.demo35.eprints-hosting.org/id/eprint/463
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
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Date Deposited:
11 Jun 2025 16:38
Revision:
15
Last Modified:
12 Jun 2025 08:56
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