Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

Abstract

BACKGROUND:
Anthracycline-induced cardiotoxicity has a variable incidence, and the development of left ventricular dysfunction is preceded by elevations in cardiac troponin concentrations. Beta-adrenergic receptor blocker and renin-angiotensin system inhibitor therapies have been associated with modest cardioprotective effects in unselected patients receiving anthracycline chemotherapy.

METHODS:
In a multicenter, prospective, randomized, open-label, blinded end-point trial, patients with breast cancer and non-Hodgkin lymphoma receiving anthracycline chemotherapy underwent serial high-sensitivity cardiac troponin testing and cardiac magnetic resonance imaging before and 6 months after anthracycline treatment. Patients at high risk of cardiotoxicity (cardiac troponin I concentrations in the upper tertile during chemotherapy) were randomized to standard care plus cardioprotection (combination carvedilol and candesartan therapy) or standard care alone. The primary outcome was adjusted change in left ventricular ejection fraction at 6 months. In low-risk nonrandomized patients with cardiac troponin I concentrations in the lower 2 tertiles, we hypothesized the absence of a 6-month change in left ventricular ejection fraction and tested for equivalence of ±2%.

RESULTS:
Between October 2017 and June 2021, 175 patients (mean age, 53 years; 87% female; 71% with breast cancer) were recruited. Patients randomized to cardioprotection (n=29) or standard care (n=28) had left ventricular ejection fractions of 69.4±7.4% and 69.1±6.1% at baseline and 65.7±6.6% and 64.9±5.9% 6 months after completion of chemotherapy, respectively. After adjustment for age, pretreatment left ventricular ejection fraction, and planned anthracycline dose, the estimated mean difference in 6-month left ventricular ejection fraction between the cardioprotection and standard care groups was −0.37% (95% CI, −3.59% to 2.85%; P=0.82). In low-risk nonrandomized patients, baseline and 6-month left ventricular ejection fractions were 69.3±5.7% and 66.4±6.3%, respectively: estimated mean difference, 2.87% (95% CI, 1.63%–4.10%; P=0.92, not equivalent).

CONCLUSIONS:
Combination candesartan and carvedilol therapy had no demonstrable cardioprotective effect in patients receiving anthracycline-based chemotherapy with high-risk on-treatment cardiac troponin I concentrations. Low-risk nonrandomized patients had similar declines in left ventricular ejection fraction, bringing into question the utility of routine cardiac troponin monitoring. Furthermore, the modest declines in left ventricular ejection fraction suggest that the value and clinical impact of early cardioprotection therapy need to be better defined in patients receiving high-dose anthracycline.

People
Henriksen, Peter A.
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Hall, Peter
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Macpherson, Iain R.
Author

Maldonado, Horacio and Dreger, Marcel and Bedgood, Lara D. and Kyriakou, Theano and Wolanska, Katarzyna I. and Rigby, Megan E. and Marotta, Valeria E. and Webster, Justine M. and Wang, Jun and Rusilowicz-Jones, Emma V. and Marshall, John F. and Coulson, Judy M. and MacPherson, Iain R. and Hurlstone, Adam and Morgan, Mark R. (2024) A trafficking regulatory subnetwork governs α V β 6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance. Science Advances, 10 (49): eadk9944. ISSN 2375-2548

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Agnew, Sommer and Crawford, Megan and MacPherson, Iain and Shiramizu, Victor and Fleming, Leanne (2024) The impact of symptom clusters on endocrine therapy adherence in patients with breast cancer. Breast, 75: 103731. ISSN 0960-9776

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Joshi, Shruti S.
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Singh, Trisha
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Maclean, Morag
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Lewis, Steff
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Rodriguez, Aryelly
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Fletcher, Alexander
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Everett, Russell J.
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Stavert, Harriet
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Broom, Angus
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Eddie, Lois
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Primrose, Lorraine
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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McVicars, Heather
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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McKay, Pam
Author

Rankin, Stephen and Fountain, Caitlin and Gemmell, Alastair J. and Quinn, Daire and Henderson, Alasdair and McClure, John and Small, Sandy and Venugopal, Balaji and McKay, Pamela and Slomka, Piotr J. and Colville, David and Petrie, Mark C. and Meléndez, Giselle C. and Lang, Ninian N. (2025) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients. Clinical Science, 139 (1). pp. 29-41. ISSN 0143-5221

Rankin, Stephen and Fountain, Caitlin and Gemmell, Alastair and Quinn, Daire and Henderson, Alasdair and McClure, John and Small, Sandy and Venugopal, Balaji and McKay, Pamela and Slomka, Piotr J. and Colville, David and Petrie, Mark C. and Meléndez, Giselle C. and Lang, Ninian N. (2024) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients using 18F-FDG positron emission tomography. bioRxiv.

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Borley, Annabel
Author

Hanna, Daire and Merrick, Sophie and Ghose, Aruni and Devlin, Michael John and Yang, Dorothy D. and Phillips, Edward and Okines, Alicia and Chopra, Neha and Papadimatraki, Elisavet and ROSS, KIRSTY and MacPherson, Iain and Boh, Zhuang Y. and Michie, Caroline O. and Swampillai, Angela and Gupta, Sunnia and Robinson, Tim and Germain, Lewis and Twelves, Chris and Atkinson, Charlotte and Konstantis, Apostolos and Riddle, Pippa and Cresti, Nicola and Naik, Jay D. and Borley, Annabel and Guppy, Amy and Schmid, Peter and Phillips, Melissa (2024) Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom. British Journal of Cancer, 130 (12). pp. 1916-1920. ISSN 0007-0920

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Rowntree, Clare
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Lord, Simon
Author

Spiliopoulou, Pavlina and Kazmi, Farasat and Aroldi, Francesca and Holmes, Thomas and Thompson, David and Griffiths, Lucinda and Qi, Cathy and Parkes, Matthew and Lord, Simon and Veal, Gareth J. and Harrison, David J. and Coyle, Vicky M. and Graham, Jill and Jeffry Evans, Thomas R. and Blagden, Sarah P. (2024) A phase I open-label, dose-escalation study of NUC-3373, a targeted thymidylate synthase inhibitor, in patients with advanced cancer (NuTide:301). Journal of Experimental and Clinical Cancer Research, 43 (1): 100. ISSN 1756-9966

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Collins, Graham
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Radford, John
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Guppy, Amy
Author

Hanna, Daire and Merrick, Sophie and Ghose, Aruni and Devlin, Michael John and Yang, Dorothy D. and Phillips, Edward and Okines, Alicia and Chopra, Neha and Papadimatraki, Elisavet and ROSS, KIRSTY and MacPherson, Iain and Boh, Zhuang Y. and Michie, Caroline O. and Swampillai, Angela and Gupta, Sunnia and Robinson, Tim and Germain, Lewis and Twelves, Chris and Atkinson, Charlotte and Konstantis, Apostolos and Riddle, Pippa and Cresti, Nicola and Naik, Jay D. and Borley, Annabel and Guppy, Amy and Schmid, Peter and Phillips, Melissa (2024) Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom. British Journal of Cancer, 130 (12). pp. 1916-1920. ISSN 0007-0920

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Williams, Michelle C.
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Japp, Alan
Author

Cleland, John and Pellicori, Pierpaolo and Graham, Fraser J. and Lane, Rebecca and Petrie, Mark C. and Ahmed, Fozia and Squire, Iain B. and Ludman, Andrew and Japp, Alan and Al-Mohammad, Abdallah and Clark, Andrew L. and Szwejkowski, Ben and Critoph, Chris and Chong, Victor and Schiff, Rebekah and Nageh, Thuraia and Glover, Jason and McMurray, John J.V. and Thomson, Elizabeth A. and Robertson, Michele and Ford, Ian and Kalra, Philip A. and Kalra, Paul R. (2024) Adjudication of hospitalizations and deaths in the IRONMAN Trial of intravenous iron for heart failure. Journal of the American College of Cardiology, 84 (18). pp. 1704-1717. ISSN 0735-1097

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Payne, John R.
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Newby, David E.
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Mills, Nick L.
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Oikonomidou, Olga
Author

Henriksen, Peter A. and Hall, Peter and MacPherson, Iain R. and Joshi, Shruti S. and Singh, Trisha and Maclean, Morag and Lewis, Steff and Rodriguez, Aryelly and Fletcher, Alexander and Everett, Russell J. and Stavert, Harriet and Broom, Angus and Eddie, Lois and Primrose, Lorraine and McVicars, Heather and McKay, Pam and Borley, Annabel and Rowntree, Clare and Lord, Simon and Collins, Graham and Radford, John and Guppy, Amy and Williams, Michelle C. and Japp, Alan and Payne, John R. and Newby, David E. and Mills, Nick L. and Oikonomidou, Olga and Lang, Ninian N. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148 (21). pp. 1680-1690. ISSN 0009-7322

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Lang, Ninian N.
Author

Elyan, Benjamin M.P. and Tan, Beatrix and Lambourg, Emilie and McAllister, David A. and Jones, Rob J. and Lang, Ninian N. and Mark, Patrick B. and Lees, Jennifer S. and Bell, Samira (2025) Incidence of cancer in people with CKD not requiring kidney replacement therapy: a systematic review and meta-analysis. Clinical Kidney Journal, 18 (5): sfaf084. ISSN 2048-8505

Elbassioni, Ali Ali Mohamed and Raheem, Anmar A. and Song, Jian and Johnston, Alexander S. and Trivett, Cara and Lin, Hong and Zhang, Haobo and Bradley, Ashley and Higgins, Erin and Mooney, Leanne and Koay, Yen Chin and O'Toole, Dylan and Herzyk, Pawel and Nixon, Colin and Blyth, Karen and O'Sullivan, John F. and Lang, Ninian N. and Berry, Colin and Braun, Thomas and Schiattarella, Gabriele G. and Giacca, Mauro and McBride, Martin W. and Nicklin, Stuart A. and Cameron, Ewan R. and Loughrey, Christopher M. and MacDonald, Eilidh A. (2025) Targeting Runx1 protects against heart failure with preserved ejection fraction. bioRxiv.

Rankin, Stephen and Fountain, Caitlin and Gemmell, Alastair J. and Quinn, Daire and Henderson, Alasdair and McClure, John and Small, Sandy and Venugopal, Balaji and McKay, Pamela and Slomka, Piotr J. and Colville, David and Petrie, Mark C. and Meléndez, Giselle C. and Lang, Ninian N. (2025) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients. Clinical Science, 139 (1). pp. 29-41. ISSN 0143-5221

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