Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
AI Summary:
The STRATIFY study aims to evaluate thoracoscopic staging in lung cancer patients with minimal pleural effusion. The study will assess the prevalence of occult pleural metastases, technical feasibility and safety, and impact on treatment plans and patient outcomes.AI Topics:
Introduction: Recurrence rate following radical therapy for lung cancer remains high, potentially reflecting occult metastatic disease, and better staging tools are required. Minimal pleural effusion (mini-PE) is associated with particularly high recurrence risk and is defined as an ipsilateral pleural collection (<1/3 hemithorax on chest radiograph), which is either too small to safely aspirate fluid for cytology using a needle, or from which fluid cytology is negative. Thoracoscopy (local anaesthetic thoracoscopy (LAT) or video-assisted thoracoscopic surgery (VATS)) is the gold-standard diagnostic test for pleural malignancy in patients with larger symptomatic effusions. Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY) will prospectively evaluate thoracoscopic staging in lung cancer associated-mini-PE for the first time.
Methods and analysis: STRATIFY is a prospective multicentre observational study. Recruitment opened in January 2020. The primary objective is to determine the prevalence of detectable occult pleural metastases (OPM). Secondary objectives include assessment of technical feasibility and safety, and the impact of thoracoscopy results on treatment plans, overall survival and recurrence free survival. Inclusion criteria are (1) suspected/confirmed stages I–III lung cancer, (2) mini-PE, (3) Performance Status 0–2 (4), radical treatment feasible if OPM excluded, (5) ≥16 years old and (6) informed consent. Exclusion criteria are any metastatic disease or contraindication to the chosen thoracoscopy method (LAT/VATS). All patients have LAT or VATS within 7 (±5) days of registration, with results returned to lung cancer teams for treatment planning. Following an interim analysis, the sample size was reduced from 96 to 50, based on a lower-than-expected OPM rate. An MRI substudy was removed in November 2022 due to pandemic-related site setup/recruitment delays. These also necessitated a no-cost recruitment extension until October 2023.
Ferguson, Jenny
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listTsim, Selina
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listKelly, Caroline
Author
Derby, Sarah and Jackson, Mark R. and Williams, Karin and Stobo, Jamie and Kelly, Caroline and Sweeting, Lorna and Shad, Shumaila and Herbert, Christopher and Short, Susan C. and Williamson, Aoife and James, Allan and Nowicki, Stefan and Bulbeck, Helen and Chalmers, Anthony (2024) Concurrent olaparib and radiotherapy in elderly patients with newly diagnosed glioblastoma: the phase I dose escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118 (5). pp. 1371-1378. ISSN 0360-3016
Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045
See full publications listAlexander, Laura
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listShad, Shumaila
Author
Derby, Sarah and Jackson, Mark R. and Williams, Karin and Stobo, Jamie and Kelly, Caroline and Sweeting, Lorna and Shad, Shumaila and Herbert, Christopher and Short, Susan C. and Williamson, Aoife and James, Allan and Nowicki, Stefan and Bulbeck, Helen and Chalmers, Anthony (2024) Concurrent olaparib and radiotherapy in elderly patients with newly diagnosed glioblastoma: the phase I dose escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118 (5). pp. 1371-1378. ISSN 0360-3016
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listNeilly, Mark
Author
Neilly, Mark D.J. and Dick, Craig and Blyth, Kevin G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14: 7. ISSN 2199-2428
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listTate, Matthew
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listZahra, Baryab
Author
Morrow, Andrew J. and Sykes, Robert and Saleh, Merna and Zahra, Baryab and MacIntosh, Alasdair and Kamdar, Anna and Bagot, Catherine and Bayes, Hannah K. and Blyth, Kevin G. and Bulluck, Heerajnarain and Carrick, David and Church, Colin and Corcoran, David and Findlay, Iain and Gibson, Vivienne and Gillespie, Lynsey and Grieve, Douglas and Hall Barrientos, Pauline and Ho, Antonia and Lang, Ninian N. and Lowe, David J. and Lennie, Vera and Macfarlane, Peter W. and Mayne, Kaitlin J. and Mark, Patrick B. and McConnachie, Alex and McGeoch, Ross and Nordin, Sabrina and Payne, Alexander and Rankin, Alastair J. and Robertson, Keith and Ryan, Nicola and Roditi, Giles and Sattar, Naveed and Stobo, David and Allwood-Spiers, Sarah and Touyz, Rhian M. and Veldtman, Gruschen and Weeden, Sarah and Weir, Robin and Watkins, Stuart and Welsh, Paul and Mangion, Kenneth and Berry, Colin (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4: 32. ISSN 2730-664X
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listSaleh, Merna
Author
Morrow, Andrew J. and Sykes, Robert and Saleh, Merna and Zahra, Baryab and MacIntosh, Alasdair and Kamdar, Anna and Bagot, Catherine and Bayes, Hannah K. and Blyth, Kevin G. and Bulluck, Heerajnarain and Carrick, David and Church, Colin and Corcoran, David and Findlay, Iain and Gibson, Vivienne and Gillespie, Lynsey and Grieve, Douglas and Hall Barrientos, Pauline and Ho, Antonia and Lang, Ninian N. and Lowe, David J. and Lennie, Vera and Macfarlane, Peter W. and Mayne, Kaitlin J. and Mark, Patrick B. and McConnachie, Alex and McGeoch, Ross and Nordin, Sabrina and Payne, Alexander and Rankin, Alastair J. and Robertson, Keith and Ryan, Nicola and Roditi, Giles and Sattar, Naveed and Stobo, David and Allwood-Spiers, Sarah and Touyz, Rhian M. and Veldtman, Gruschen and Weeden, Sarah and Weir, Robin and Watkins, Stuart and Welsh, Paul and Mangion, Kenneth and Berry, Colin (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4: 32. ISSN 2730-664X
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listCowell, Gordon
Author
Kidd, Andrew C. and Cowell, Gordon W. and Martin, Geoffrey A. and Ferguson, Jenny and Fennell, Dean A. and Evison, Matt and Blyth, Kevin G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42: 100856. ISSN 2468-2942
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listBanks, Elspeth
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listGrundy, Seamus
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listCorcoran, John
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listDowner, Nicola
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listStanton, Andrew
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listEvison, Matthew
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listRahman, Najib
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listMaskell, Nick
Author
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listBlyth, Kevin
Author
Alkarn, Ahmed and Stapleton, Liam J. and Eleftheriou, Dimitra and Stewart, Laura and Chalmers, George and Hamed, Ahmad and Hussein, Khaled and Blyth, Kevin G. and van der Hors, Joris C. and Maclay, John D. (2025) Real life pre-operative nodal staging accuracy in non-small cell lung cancer and its relationship with survival. Diagnostics, 15 (4): 430. ISSN 2075-4418
Neilly, Mark D.J. and Dick, Craig and Blyth, Kevin G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14: 7. ISSN 2199-2428
Frankell, Alexander M. and Dietzen, Michelle and Al Bakir, Maise and Lim, Emilia L. and Karasaki, Takahiro and Ward, Sophia and Veeriah, Selvaraju and Colliver, Emma and Huebner, Ariana and Bunkum, Abigail and Hill, Mark S. and Grigoriadis, Kristiana and Moore, David A. and Black, James R. M. and Liu, Wing Kin and Thol, Kerstin and Pich, Oriol and Watkins, Thomas B. K. and Naceur-Lombardelli, Cristina and Cook, Daniel E. and Salgado, Roberto and Wilson, Gareth A. and Bailey, Chris and Angelova, Mihaela and Bentham, Robert and Martínez-Ruiz, Carlos and Abbosh, Christopher and Nicholson, Andrew G. and Le Quesne, John and Biswas, Dhruva and Rosenthal, Rachel and Puttick, Clare and Hessey, Sonya and Lee, Claudia and Prymas, Paulina and Toncheva, Antonia and Smith, Jon and Xing, Wei and Nicod, Jerome and Price, Gillian and Kerr, Keith M. and Naidu, Babu and Middleton, Gary and Blyth, Kevin G. and Fennell, Dean A. and Forster, Martin D. and Lee, Siow Ming and Falzon, Mary and Hewish, Madeleine and Shackcloth, Michael J. and Lim, Eric and Benafif, Sarah and Russell, Peter and Boleti, Ekaterini and Krebs, Matthew G. and Lester, Jason F. and Papadatos-Pastos, Dionysis and Ahmad, Tanya and Thakrar, Ricky M. and Lawrence, David and Navani, Neal and Janes, Sam M. and Dive, Caroline and Blackhall, Fiona H. and Summers, Yvonne and Cave, Judith and Marafioti, Teresa and Herrero, Javier and Quezada, Sergio A. and Peggs, Karl S. and Schwarz, Roland F. and Van Loo, Peter and Miedema, Daniël M. and Birkbak, Nicolai J. and Hiley, Crispin T. and Hackshaw, Allan and Zaccaria, Simone and TRACERx Consortium and Jamal-Hanjani, Mariam and McGranahan, Nicholas and Swanton, Charles (2024) Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 631 (8022): E15. ISSN 1476-4687
See full publications listAvailable under License Creative Commons Attribution.
Download (1MB) | Preview
308854_suppl.pdf
Available under License Creative Commons Attribution.
Download (6MB) | Preview