Ajetunmobi, Olabayo H. and Badali, Hamid and Romo, Jesus A. and Ramage, Gordon and Lopez-Ribot, Jose L. (2023) Antifungal therapy of Candida biofilms: past, present and future. Biofilm, 5: 100126. ISSN 2590-2075
AI Summary:
Candida species are capable of forming highly resistant biofilms on different surfaces, posing a significant threat to therapy. Despite the scarcity of antifungal agents and their limited effectiveness against biofilms, researchers remain optimistic about conquering the major challenges of Candida biofilm therapy within a reasonable timeframe.AI Topics:
Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which poses an additional significant threat and further complicates therapy of these infections. There is a scarcity of antifungal agents, and their effectiveness, particularly against biofilms, is limited. Here we provide a historical perspective on antifungal agents and therapy of Candida biofilms. As we reflect upon the past, consider the present, and look towards the future of antifungal therapy of Candida biofilms, we believe that there are reasons to remain optimistic, and that the major challenges of Candida biofilm therapy can be conquered within a reasonable timeframe.
Ajetunmobi, Olabayo H.
Author
Ajetunmobi, Olabayo H. and Badali, Hamid and Romo, Jesus A. and Ramage, Gordon and Lopez-Ribot, Jose L. (2023) Antifungal therapy of Candida biofilms: past, present and future. Biofilm, 5: 100126. ISSN 2590-2075
See full publications listBadali, Hamid
Author
Ajetunmobi, Olabayo H. and Badali, Hamid and Romo, Jesus A. and Ramage, Gordon and Lopez-Ribot, Jose L. (2023) Antifungal therapy of Candida biofilms: past, present and future. Biofilm, 5: 100126. ISSN 2590-2075
See full publications listRomo, Jesus A.
Author
Ajetunmobi, Olabayo H. and Badali, Hamid and Romo, Jesus A. and Ramage, Gordon and Lopez-Ribot, Jose L. (2023) Antifungal therapy of Candida biofilms: past, present and future. Biofilm, 5: 100126. ISSN 2590-2075
See full publications listRamage, Gordon
Author
Allkja, Jontana and Bakri, Ahmed and Short, Bryn and Gilmour, Andrew and Brown, Jason L. and Bal, Abhijit M. and Newby, Kelly J.M. and Jenkins, Toby and Short, Rob D. and Williams, Craig and Ramage, Gordon (2025) Investigating the prevalence of fungi in diabetic ulcers: an under-recognised contributor to polymicrobial biofilms. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (4): e70025. ISSN 0903-4641
Ware, Alicia and Johnston, William and Delaney, Christopher and Butcher, Mark C. and Ramage, Gordon and Price, Lesley and Butcher, John and Kean, Ryan (2025) Dry surface biofilm formation by Candida auris facilitates persistence and tolerance to sodium hypochlorite. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (4): e70022. ISSN 0903-4641
Abduljalil, Hafsa and Alshanta, Om Alkhir and Chougule, Safa and Butcher, Mark and Short, Bryn and Mclean, William and Parry, Neil and O'Keeffe, Joanne and Ramage, Gordon (2025) Lactams exhibit potent antifungal activity against monospecies and multispecies interkingdom biofilms on a novel hydrogel skin model. APMIS: Journal of Pathology, Microbiology and Immunology, 133 (1): e13510. ISSN 0903-4641
See full publications listLopez-Ribot, Jose L.
Author
Ajetunmobi, Olabayo H. and Badali, Hamid and Romo, Jesus A. and Ramage, Gordon and Lopez-Ribot, Jose L. (2023) Antifungal therapy of Candida biofilms: past, present and future. Biofilm, 5: 100126. ISSN 2590-2075
See full publications listAvailable under License Creative Commons Attribution.
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