Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

Abstract

An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still a challenge. Using an integrated screening approach to identify cancer-specific vulnerabilities, we identified complement receptor C5aR1 as a druggable target, which when inhibited improved radiotherapy, even in tumors displaying immunosuppressive features and poor CD8+ T cell infiltration. While C5aR1 is well-known for its role in the immune compartment, we found that C5aR1 is also robustly expressed on malignant epithelial cells, highlighting potential tumor cell–specific functions. C5aR1 targeting resulted in increased NF-κB–dependent apoptosis specifically in tumors and not normal tissues, indicating that, in malignant cells, C5aR1 primarily regulated cell fate. Collectively, these data revealed that increased complement gene expression is part of the stress response mounted by irradiated tumors and that targeting C5aR1 could improve radiotherapy, even in tumors displaying immunosuppressive features.

People
Beach, Callum
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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MacLean, David
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Majorova, Dominika
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Melemenidis, Stavros
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Nambiar, Dhanya K.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Kim, Ryan K.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Valbuena, Gabriel N.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Guglietta, Silvia
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Krieg, Carsten
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Darvish, Damavandi Mahnaz
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Suwa, Tatsuya
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Easton, Alistair
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Hillson, Lily V.S.
Author

Galbraith, Norman J. and Quinn, Jean A. and Al-Badran, Sara Sf and Pennel, Kathryn A.F. and Hillson, Lily V.S. and Hatthakarnkul, Phimmada and McKenzie, Molly and Maka, Noori and Loi, Lynette and Frixou, Mikaela and Steele, Colin W. and Roxburgh, Campbell S. and Horgan, Paul G. and McMillan, Donald C. and Edwards, Joanne (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48: 102064. ISSN 1944-7124

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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McCulloch, Ashley K.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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McMahon, Ross K.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Pennel, Kathryn A.F.
Author

Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377

Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X

Galbraith, Norman J. and Quinn, Jean A. and Al-Badran, Sara Sf and Pennel, Kathryn A.F. and Hillson, Lily V.S. and Hatthakarnkul, Phimmada and McKenzie, Molly and Maka, Noori and Loi, Lynette and Frixou, Mikaela and Steele, Colin W. and Roxburgh, Campbell S. and Horgan, Paul G. and McMillan, Donald C. and Edwards, Joanne (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48: 102064. ISSN 1944-7124

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Edwards, J.
Author

Thompson, Joshua J. and MacLeod, Nicholas and Will, Sarah and O'Rourke, Fraser and McGovern, Josh and Roxburgh, Campbell and Edwards, Joanne and Dolan, Ross D. and McMillan, Donald C. (2025) The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. BMC Cancer, 25: 543. ISSN 1471-2407

Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377

Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X

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O'Cathail, Sean M.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Domingo, Enric
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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Moon, Eui Jung
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Jiang, Dadi
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Jiang, Yanyan
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Zhang, Q.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Koong, Albert C.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Woodruff, Trent M.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Graves, Edward E.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Maughan, Tim
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Buczacki, Simon J.A.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Stucki, Manuel
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Le, Quynh-Thu
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Leedham, Simon J.
Author

Malla, Sudhir B. and Byrne, Ryan M. and Lafarge, Maxime W. and Corry, Shania M. and Fisher, Natalie C. and Tsantoulis, Petros K. and Mills, Megan L. and Ridgway, Rachel A. and Lannagan, Tamsin R. M. and Najumudeen, Arafath K. and Gilroy, Kathryn L. and Amirkhah, Raheleh and Maguire, Sarah L. and Mulholland, Eoghan J. and Belnoue-Davis, Hayley L. and Grassi, Elena and Viviani, Marco and Rogan, Emily and Redmond, Keara L. and Sakhnevych, Svetlana and McCooey, Aoife J. and Bull, Courtney and Hoey, Emily and Sinevici, Nicoleta and Hall, Holly and Ahmaderaghi, Baharak and Domingo, Enric and Blake, Andrew and Richman, Susan D. and Isella, Claudio and Miller, Crispin and Bertotti, Andrea and Trusolino, Livio and Loughrey, Maurice B. and Kerr, Emma M. and Tejpar, Sabine and S:CORT Consortium and Maughan, Timothy S. and Lawler, Mark and Campbell, Andrew D. and Leedham, Simon J. and Koelzer, Viktor H. and Sansom, Owen J. and Dunne, Philip D. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56 (6): 1321. ISSN 1061-4036

Malla, Sudhir B. and Byrne, Ryan M. and Lafarge, Maxime W. and Corry, Shania M. and Fisher, Natalie C. and Tsantoulis, Petros K. and Mills, Megan L. and Ridgway, Rachel A. and Lannagan, Tamsin R. M. and Najumudeen, Arafath K. and Gilroy, Kathryn L. and Amirkhah, Raheleh and Maguire, Sarah L. and Mulholland, Eoghan J. and Belnoue-Davis, Hayley L. and Grassi, Elena and Viviani, Marco and Rogan, Emily and Redmond, Keara L. and Sakhnevych, Svetlana and McCooey, Aoife J. and Bull, Courtney and Hoey, Emily and Sinevici, Nicoleta and Hall, Holly and Ahmaderaghi, Baharak and Domingo, Enric and Blake, Andrew and Richman, Susan D. and Isella, Claudio and Miller, Crispin and Bertotti, Andrea and Trusolino, Livio and Loughrey, Maurice B. and Kerr, Emma M. and Tejpar, Sabine and S:CORT consortium and Maughan, Timothy S. and Lawler, Mark and Campbell, Andrew D. and Leedham, Simon J. and Koelzer, Viktor H. and Sansom, Owen J. and Dunne, Philip D. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56 (3). pp. 458-472. ISSN 1061-4036

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Giaccia, Amato J.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Olcina, Monica M.
Author

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

See full publications list
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