Crofts, Samuel J.C. and Latorre Crespo, Eric and Chandra, Tamir (2023) DNA methylation rates scale with maximum lifespan across mammals. Nature Aging, 4. pp. 27-32. ISSN 2662-8465

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Abstract

DNA methylation rates have previously been found to broadly correlate with maximum lifespan in mammals, yet no precise relationship has been observed. We developed a statistically robust framework to compare methylation rates at conserved age-related sites across mammals. We found that methylation rates negatively scale with maximum lifespan in both blood and skin. The emergence of explicit scaling suggests that methylation rates are, or are linked to, an evolutionary constraint on maximum lifespan acting across diverse mammalian lineages.

Information
Title DNA methylation rates scale with maximum lifespan across mammals
Creators Crofts, Samuel J.C. and Latorre Crespo, Eric and Chandra, Tamir
Identification Number 10.1038/s43587-023-00535-6
Date 4 December 2023
Divisions College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher Nature Publishing Group US
Additional Information S.J.C.C. is supported by the Wellcome Trust Hosts, Pathogens and Global Health Programme (grant number grant.226831/Z/22/Z). E.L.-C. is a cross-disciplinary postdoctoral fellow supported by funding from the University of Edinburgh and the Medical Research Council (MC_UU_00009/2). T.C. is supported through a Chancellor’s Fellow award at the University of Edinburgh and the MRC Human Genetics Unit.
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Item Type Article
Depositing User Unnamed user with email ejo1f20@soton.ac.uk
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Date Deposited 11 Jun 2025 16:38
Revision 14
Last Modified 12 Jun 2025 09:04
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