Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
AI Summary:
A systematic literature review and meta-analysis found that higher levels of IL-6, but not IL-1, may be associated with an increased risk of developing hypertension.AI Topics:
Background:
Immune responses play a significant role in hypertension, though the importance of key inflammatory mediators remains to be defined. We used a systematic literature review and meta-analysis to study the associations between key cytokines and incident hypertension.
Methods:
We performed a systematic search of Pubmed/Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), for peer-reviewed studies published up to August 2022. Incident hypertension was defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg and/or the use of antihypertensive medications. Random effects meta-analyses were used to calculate pooled hazard ratios (HRs)/risk ratios (RRs) and 95% confidence intervals by cytokine levels (highest vs. lowest quartile).
Results:
Only IL-6 and IL-1β levels have evidence allowing for quantitative evaluation concerning the onset of hypertension. Six studies (10,406 participants, 2,932 incident cases) examined the association of IL-6 with incident hypertension. The highest versus lowest quartile of circulating IL-6 was associated with a significant HR/RR of hypertension (1.61, 95% CI: 1.00 to 2.60; I2=87%). After adjusting for potential confounders, including body mass index (BMI), HR/RR was no longer significant (HR/RR: 1.24; 95% CI, 0.96 to 1.61; I2= 56%). About IL-1β, neither the crude (HR/RR: 1.03; 95% CI, 0.60 to 1.76; n=2) nor multivariate analysis (HR/RR: 0.97, 95% CI, 0.60 to 1.56; n=2) suggested a significant association with the risk of developing hypertension.
Conclusions:
A limited number of studies suggest that higher IL-6, but not IL-1β, might be associated with the development of hypertension.
Caiazzo, Elisabetta
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listSharma, Malvika
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listRezig, Asma O.M.
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listMorsy, Moustafa I.
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listCzesnikiewicz-Guzik, Marta
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listIalenti, Armando
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listSulicka-Grodzicka, Joanna
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listPellicori, Pierpaolo
Author
Cleland, John and Pellicori, Pierpaolo and Graham, Fraser J. and Lane, Rebecca and Petrie, Mark C. and Ahmed, Fozia and Squire, Iain B. and Ludman, Andrew and Japp, Alan and Al-Mohammad, Abdallah and Clark, Andrew L. and Szwejkowski, Ben and Critoph, Chris and Chong, Victor and Schiff, Rebekah and Nageh, Thuraia and Glover, Jason and McMurray, John J.V. and Thomson, Elizabeth A. and Robertson, Michele and Ford, Ian and Kalra, Philip A. and Kalra, Paul R. (2024) Adjudication of hospitalizations and deaths in the IRONMAN Trial of intravenous iron for heart failure. Journal of the American College of Cardiology, 84 (18). pp. 1704-1717. ISSN 0735-1097
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listCrouch, Simone H.
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listSchutte, Aletta E.
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listBruzzese, Dario
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listMaffia, Pasquale
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listGuzik, Tomasz J.
Author
Caiazzo, Elisabetta and Sharma, Malvika and Rezig, Asma O.M. and Morsy, Moustafa I. and Czesnikiewicz-Guzik, Marta and Ialenti, Armando and Sulicka-Grodzicka, Joanna and Pellicori, Pierpaolo and Crouch, Simone H. and Schutte, Aletta E. and Bruzzese, Dario and Maffia, Pasquale and Guzik, Tomasz J. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200: 107050. ISSN 1043-6618
See full publications listAvailable under License Creative Commons Attribution.
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