Kidd, Andrew C. and Cowell, Gordon W. and Martin, Geoffrey A. and Ferguson, Jenny and Fennell, Dean A. and Evison, Matt and Blyth, Kevin G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42: 100856. ISSN 2468-2942
AI Summary:
This study investigated the prevalence, prognostic significance, and clinicopathological correlates of sarcopenia and adipopenia in patients with pleural mesothelioma receiving chemotherapy. The results showed that T4 muscle indices were feasible in all cases and outperformed L3 values in prognostication.AI Topics:
Introduction:
Altered body composition is associated with adverse survival in multiple cancers. We determined the prevalence, prognostic significance and clinicopathological correlates of sarcopenia and adipopenia in Pleural Mesothelioma (PM) patients receiving chemotherapy.
Methods:
We performed a multi-centre retrospective cohort study. Clinical data and CT images were retrieved for 111 patients from 4 UK centres. Skeletal muscle (at L3 and T4) and fat tissue areas (at L3 only) were measured on pre- and post-chemotherapy CT scans (ImageJ software) and normalised for height. Pre-chemotherapy sarcopenia and adipopenia were defined using validated thresholds, where available or indices <25th percentile. Muscle/fat loss were defined by <0% change (%∆) between CT scans. Extreme muscle/fat loss were defined by <25th percentile of %∆. Overall survival associations were evaluated using Kaplan-Meier methodology ± Cox proportional hazards models.
Results:
T4 and L3 measurements were possible in 111/111 and 91/111 (82%). L3 sarcopenia was observed at baseline in 35% (32/91); all other features were observed in 25% at baseline, as defined a priori. Body composition changes during chemotherapy were heterogeneous. Overall, 61.5% and 53.1% patients lost muscle at L3 and T4. 60.4% lost fat (at L3 only). Extreme T4 muscle loss and total fat loss were independently prognostic (HR 2.99, p<0.001; HR 1.92, p=0.014). Pre-chemotherapy T4 muscle indices were inversely associated with age. No associations were observed with tumour volume, histology, weight, inflammatory markers.
Conclusion:
T4 muscle indices were feasible in all cases and outperformed L3 values in prognostication. Extreme T4 muscle and total fat loss were independently prognostic.
Kidd, Andrew C.
Author
Cartwright, Douglas and Kidd, Andrew C. and Ansel, Sonam and Ascierto, Maria Libera and Spiliopoulou, Pavlina (2025) Oncogenic signalling pathways in cancer immunotherapy: leader or follower in this delicate dance? International Journal of Molecular Sciences, 26 (9): 4393. ISSN 1661-6596
Kidd, Andrew C. and Cowell, Gordon W. and Martin, Geoffrey A. and Ferguson, Jenny and Fennell, Dean A. and Evison, Matt and Blyth, Kevin G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42: 100856. ISSN 2468-2942
See full publications listCowell, Gordon
Author
Kidd, Andrew C. and Cowell, Gordon W. and Martin, Geoffrey A. and Ferguson, Jenny and Fennell, Dean A. and Evison, Matt and Blyth, Kevin G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42: 100856. ISSN 2468-2942
Ferguson, Jenny and Tsim, Selina and Kelly, Caroline and Alexander, Laura and Shad, Shumaila and Neilly, Mark and Tate, Matthew and Zahra, Baryab and Saleh, Merna and Cowell, Gordon and Banks, Elspeth and Grundy, Seamus and Corcoran, John and Downer, Nicola and Stanton, Andrew and Evison, Matthew and Rahman, Najib and Maskell, Nick and Blyth, Kevin (2023) Staging by Thoracoscopy in potentially radically treatable Lung Cancer associated with Minimal Pleural Effusion (STRATIFY): Protocol of a prospective, multicentre, observational study. BMJ Open Respiratory Research, 10: e001771. ISSN 2052-4439
See full publications listMartin, Geoffrey A.
Author
Kidd, Andrew C. and Cowell, Gordon W. and Martin, Geoffrey A. and Ferguson, Jenny and Fennell, Dean A. and Evison, Matt and Blyth, Kevin G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42: 100856. ISSN 2468-2942
See full publications listFerguson, Jenny
Author
Kidd, Andrew C. and Cowell, Gordon W. and Martin, Geoffrey A. and Ferguson, Jenny and Fennell, Dean A. and Evison, Matt and Blyth, Kevin G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42: 100856. ISSN 2468-2942
See full publications listFennell, Dean A.
Author
Frankell, Alexander M. and Dietzen, Michelle and Al Bakir, Maise and Lim, Emilia L. and Karasaki, Takahiro and Ward, Sophia and Veeriah, Selvaraju and Colliver, Emma and Huebner, Ariana and Bunkum, Abigail and Hill, Mark S. and Grigoriadis, Kristiana and Moore, David A. and Black, James R. M. and Liu, Wing Kin and Thol, Kerstin and Pich, Oriol and Watkins, Thomas B. K. and Naceur-Lombardelli, Cristina and Cook, Daniel E. and Salgado, Roberto and Wilson, Gareth A. and Bailey, Chris and Angelova, Mihaela and Bentham, Robert and Martínez-Ruiz, Carlos and Abbosh, Christopher and Nicholson, Andrew G. and Le Quesne, John and Biswas, Dhruva and Rosenthal, Rachel and Puttick, Clare and Hessey, Sonya and Lee, Claudia and Prymas, Paulina and Toncheva, Antonia and Smith, Jon and Xing, Wei and Nicod, Jerome and Price, Gillian and Kerr, Keith M. and Naidu, Babu and Middleton, Gary and Blyth, Kevin G. and Fennell, Dean A. and Forster, Martin D. and Lee, Siow Ming and Falzon, Mary and Hewish, Madeleine and Shackcloth, Michael J. and Lim, Eric and Benafif, Sarah and Russell, Peter and Boleti, Ekaterini and Krebs, Matthew G. and Lester, Jason F. and Papadatos-Pastos, Dionysis and Ahmad, Tanya and Thakrar, Ricky M. and Lawrence, David and Navani, Neal and Janes, Sam M. and Dive, Caroline and Blackhall, Fiona H. and Summers, Yvonne and Cave, Judith and Marafioti, Teresa and Herrero, Javier and Quezada, Sergio A. and Peggs, Karl S. and Schwarz, Roland F. and Van Loo, Peter and Miedema, Daniël M. and Birkbak, Nicolai J. and Hiley, Crispin T. and Hackshaw, Allan and Zaccaria, Simone and TRACERx Consortium and Jamal-Hanjani, Mariam and McGranahan, Nicholas and Swanton, Charles (2024) Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 631 (8022): E15. ISSN 1476-4687
Kidd, Andrew C. and Cowell, Gordon W. and Martin, Geoffrey A. and Ferguson, Jenny and Fennell, Dean A. and Evison, Matt and Blyth, Kevin G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42: 100856. ISSN 2468-2942
See full publications listEvison, Matt
Author
Kidd, Andrew C. and Cowell, Gordon W. and Martin, Geoffrey A. and Ferguson, Jenny and Fennell, Dean A. and Evison, Matt and Blyth, Kevin G. (2024) The prevalence and prognostic significance of sarcopenia and adipopenia in pleural mesothelioma. Cancer Treatment and Research Communications, 42: 100856. ISSN 2468-2942
See full publications listBlyth, Kevin
Author
Alkarn, Ahmed and Stapleton, Liam J. and Eleftheriou, Dimitra and Stewart, Laura and Chalmers, George and Hamed, Ahmad and Hussein, Khaled and Blyth, Kevin G. and van der Hors, Joris C. and Maclay, John D. (2025) Real life pre-operative nodal staging accuracy in non-small cell lung cancer and its relationship with survival. Diagnostics, 15 (4): 430. ISSN 2075-4418
Neilly, Mark D.J. and Dick, Craig and Blyth, Kevin G. (2025) Non-Specific Pleuritis: an update. Current Pulmonology Reports, 14: 7. ISSN 2199-2428
Frankell, Alexander M. and Dietzen, Michelle and Al Bakir, Maise and Lim, Emilia L. and Karasaki, Takahiro and Ward, Sophia and Veeriah, Selvaraju and Colliver, Emma and Huebner, Ariana and Bunkum, Abigail and Hill, Mark S. and Grigoriadis, Kristiana and Moore, David A. and Black, James R. M. and Liu, Wing Kin and Thol, Kerstin and Pich, Oriol and Watkins, Thomas B. K. and Naceur-Lombardelli, Cristina and Cook, Daniel E. and Salgado, Roberto and Wilson, Gareth A. and Bailey, Chris and Angelova, Mihaela and Bentham, Robert and Martínez-Ruiz, Carlos and Abbosh, Christopher and Nicholson, Andrew G. and Le Quesne, John and Biswas, Dhruva and Rosenthal, Rachel and Puttick, Clare and Hessey, Sonya and Lee, Claudia and Prymas, Paulina and Toncheva, Antonia and Smith, Jon and Xing, Wei and Nicod, Jerome and Price, Gillian and Kerr, Keith M. and Naidu, Babu and Middleton, Gary and Blyth, Kevin G. and Fennell, Dean A. and Forster, Martin D. and Lee, Siow Ming and Falzon, Mary and Hewish, Madeleine and Shackcloth, Michael J. and Lim, Eric and Benafif, Sarah and Russell, Peter and Boleti, Ekaterini and Krebs, Matthew G. and Lester, Jason F. and Papadatos-Pastos, Dionysis and Ahmad, Tanya and Thakrar, Ricky M. and Lawrence, David and Navani, Neal and Janes, Sam M. and Dive, Caroline and Blackhall, Fiona H. and Summers, Yvonne and Cave, Judith and Marafioti, Teresa and Herrero, Javier and Quezada, Sergio A. and Peggs, Karl S. and Schwarz, Roland F. and Van Loo, Peter and Miedema, Daniël M. and Birkbak, Nicolai J. and Hiley, Crispin T. and Hackshaw, Allan and Zaccaria, Simone and TRACERx Consortium and Jamal-Hanjani, Mariam and McGranahan, Nicholas and Swanton, Charles (2024) Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature, 631 (8022): E15. ISSN 1476-4687
See full publications listAvailable under License Creative Commons Attribution.
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