Spiliopoulou, Pavlina and Lopes, Carlos Diego Holanda and Spreafico, Anna (2024) Promising and minimally invasive biomarkers: targeting melanoma. Cells, 13 (1): 19. ISSN 2073-4409
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The therapeutic landscape of malignant melanoma has been radically reformed in recent years, with novel treatments emerging. Large-scale tumour genomic characterization has accurately classified malignant melanoma into four different genomic subtypes so far.AI Topics:
The therapeutic landscape of malignant melanoma has been radically reformed in recent years, with novel treatments emerging in both the field of cancer immunotherapy and signalling pathway inhibition. Large-scale tumour genomic characterization has accurately classified malignant melanoma into four different genomic subtypes so far. Despite this, only somatic mutations in BRAF oncogene, as assessed in tumour biopsies, has so far become a validated predictive biomarker of treatment with small molecule inhibitors. The biology of tumour evolution and heterogeneity has uncovered the current limitations associated with decoding genomic drivers based only on a single-site tumour biopsy. There is an urgent need to develop minimally invasive biomarkers that accurately reflect the real-time evolution of melanoma and that allow for streamlined collection, analysis, and interpretation. These will enable us to face challenges with tumour tissue attainment and process and will fulfil the vision of utilizing “liquid biopsy” to guide clinical decisions, in a manner akin to how it is used in the management of haematological malignancies. In this review, we will summarize the most recent published evidence on the role of minimally invasive biomarkers in melanoma, commenting on their future potential to lead to practice-changing discoveries.
Spiliopoulou, Pavlina
Author
Cartwright, Douglas and Kidd, Andrew C. and Ansel, Sonam and Ascierto, Maria Libera and Spiliopoulou, Pavlina (2025) Oncogenic signalling pathways in cancer immunotherapy: leader or follower in this delicate dance? International Journal of Molecular Sciences, 26 (9): 4393. ISSN 1661-6596
Genta, S. and Araujo, D.V. and Hueniken, K. and Pipinikas, C. and Ventura, R. and Rojas, P. and Jones, G. and Butler, M.O. and Saibil, S.D. and Yu, C. and Easson, A. and Covelli, A. and Sauder, M.B. and Fournier, C. and Saeed Kamil, Z. and Rogalla, P. and Arteaga, D.P. and Vornicova, O. and Spiliopoulou, Pavlina and Muniz, T.P. and Siu, L.L. and Spreafico, A. (2024) Bespoke ctDNA for longitudinal detection of molecular residual disease in high-risk melanoma patients. ESMO Open, 9 (11): 103978. ISSN 2059-7029
Spear, Sarah and Le Saux, Olivia and Mirza, Hasan B. and Iyer, Nayana and Tyson, Katie and Grundland Freile, Fabio and Walton, Josephine B. and Woodman, Chloe and Jarvis, Sheba and Ennis, Darren P. and Aguirre Hernandez, Carmen and Xu, Yuewei and Spiliopoulou, Pavlina and Brenton, James D. and Costa-Pereira, Ana P. and Cook, David P. and Vanderhyden, Barbara C. and Keun, Hector C. and Triantafyllou, Evangelos and Arnold, James N. and McNeish, Iain A. (2024) PTEN loss shapes macrophage dynamics in high grade serous ovarian carcinoma. Cancer Research. ISSN 0008-5472 (In Press)
See full publications listLopes, Carlos Diego Holanda
Author
Spiliopoulou, Pavlina and Lopes, Carlos Diego Holanda and Spreafico, Anna (2024) Promising and minimally invasive biomarkers: targeting melanoma. Cells, 13 (1): 19. ISSN 2073-4409
See full publications listSpreafico, Anna
Author
Thakral, Abhinav and Lee, John JW. and Hou, Tianzhichao and Hueniken, Katrina and Dudding, Tom and Gormley, Mark and Virani, Shama and Olshan, Andrew and Diergaarde, Brenda and Ness, Andrew R. and Waterboer, Tim and Smith-Byrne, Karl and Brennan, Paul and Hayes, D. Neil and Sanderson, Eleanor and Brown, M. Catherine and Huang, Sophie and Bratman, Scott V. and Spreafico, Anna and De Almeida, John and Davies, Joel C. and Bierut, Laura and Macfarlane, Gary J. and Lagiou, Pagona and Lagiou, Areti and Polesel, Jerry and Agudo, Antonio and Alemany, Laia and Ahrens, Wolfgang and Healy, Claire M. and Conway, David I. and Nygard, Mari and Canova, Cristina and Holcatova, Ivana and Richiardi, Lorenzo and Znaor, Ariana and Goldstein, David P. and Hung, Rayjean J. and Xu, Wei and Liu, Geoffrey and Espin-Garcia, Osvaldo (2024) Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study. Nature Communications, 15: 7835. ISSN 2041-1723
Spiliopoulou, Pavlina and Lopes, Carlos Diego Holanda and Spreafico, Anna (2024) Promising and minimally invasive biomarkers: targeting melanoma. Cells, 13 (1): 19. ISSN 2073-4409
Genta, Sofia and Lajkosz, Katherine and Yee, Noelle R. and Spiliopoulou, Pavlina and Heirali, Alya and Hansen, Aaron R. and Siu, Lillian L. and Saibil, Sam and Stayner, Lee-Anne and Yanekina, Maryia and Sauder, Maxwell B. and Keshavarzi, Sareh and Salawu, Abdulazeez and Vornicova, Olga and Butler, Marcus O. and Bedard, Philippe L. and Razak, Albiruni R. Abdul and Rottapel, Robert and Chruscinski, Andrzej and Coburn, Bryan and Spreafico, Anna (2023) Autoimmune PaneLs as PrEdictors of Toxicity in Patients TReated with Immune Checkpoint InhibiTors (ALERT). Journal of Experimental and Clinical Cancer Research, 42 (1): 276. ISSN 1756-9966
See full publications listAvailable under License Creative Commons Attribution.
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