Nyamondo, Kudzai and Wheadon, Helen (2024) Microenvironment alterations through time leading to myeloid malignancies. British Journal of Pharmacology, 181 (2). pp. 283-294. ISSN 0007-1188
AI Summary:
The microenvironment plays a critical role in haematopoietic stem cell development, self-renewal, differentiation and maintenance. The bone marrow microenvironment is impacted by ageing, the onset of age-related clonal haematopoiesis and the development of myeloid malignancies.AI Topics:
The microenvironment plays a critical role in haematopoietic stem cell (HSC) development, self-renewal, differentiation and maintenance by providing a supportive cellular framework and essential molecular cues to sustain homeostasis. In ageing and development of age-related clonal haematopoiesis (ARCH), the combined contribution of intrinsic alterations in HSCs and their surrounding microenvironment can promote myeloid skewing and release of pro-inflammatory cytokines. A pro-inflammatory microenvironment is a common feature in the initiation and sustenance of several myeloid malignancies. Furthermore, remodelling of the microenvironment is recognised to potentiate the survival of malignant over normal cells. This review explores microenvironmental interactions in the haematopoietic system of adults, especially how the bone marrow (BM) microenvironment is impacted by ageing, the onset of ARCH and the development of myeloid malignancies. In addition, we also discuss the possible role inflammageing and chronic inflammatory conditions play in altering the BM microenvironment dynamics. Finally, we explore the importance of in vitro models that accurately recapitulate different aspects of the BM microenvironment in order to study normal and malignant haematopoiesis.
Nyamondo, Kudzai
Author
Busch, Caroline and Nyamondo, Kudzai and Wheadon, Helen (2024) Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research. Experimental Hematology, 135: 104233. ISSN 0301-472X
Nyamondo, Kudzai and Wheadon, Helen (2024) Microenvironment alterations through time leading to myeloid malignancies. British Journal of Pharmacology, 181 (2). pp. 283-294. ISSN 0007-1188
See full publications listWheadon, Helen
Author
Donnelly, Hannah and Ross, Ewan and Xiao, Yinbo and Hermantara, Rio and Taqi, Aqeel and Doherty-Boyd, W. Sebastian and Cassels, Jennifer and Tsimbouri, Penelope M. and Dunne, Karen M. and Hay, Jodie and Cheng, Annie and Meek, R.M. Dominic and Jain, Nikhil and West, Christopher and Wheadon, Helen and Michie, Alison M. and Peault, Bruno and West, Adam G. and Salmeron-Sanchez, Manuel and Dalby, Matthew J. (2024) Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nature Communications, 15: 5791. ISSN 2041-1723
Busch, Caroline and Nyamondo, Kudzai and Wheadon, Helen (2024) Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research. Experimental Hematology, 135: 104233. ISSN 0301-472X
Dawson, Amy and Zarou, Martha M. and Prasad, Bodhayan and Bittencourt-Silvestre, Joana and Zerbst, Désirée and Himonas, Ekaterini and Hsieh, Ya-Ching and van Loon, Isabel and Rodriguez Blanco, Giovanny and Ianniciello, Angela and Kerekes, Zsombor and Krishnan, Vaidehi and Agarwal, Puneet and Almasoudi, Hassan and McCluskey, Laura and Hopcroft, Lisa E.M. and Scott, Mary T. and Baquero, Pablo and Dunn, Karen and Vetrie, David and Copland, Mhairi and Bhatia, Ravi and Coffelt, Seth B. and Tiong, Ong Sin and Wheadon, Helen and Zanivan, Sara and Kirschner, Kristina and Helgason, G. Vignir (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15: 1090. ISSN 2041-1723
See full publications listAvailable under License Creative Commons Attribution.
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