Miari, Katerina E. and Williams, Mark T. S. (2024) Stromal bone marrow fibroblasts and mesenchymal stem cells support acute myeloid leukaemia cells and promote therapy resistance. British Journal of Pharmacology, 181 (2). pp. 216-237. ISSN 0007-1188
AI Summary:
The bone marrow stroma plays a crucial role in supporting blood cell development. However, an abnormal clone can lead to acute myeloid leukaemia (AML). Despite advances in understanding the pathophysiology of AML, patient survival remains suboptimal due to therapy resistance.AI Topics:
The bone marrow (BM) is the primary site of adult haematopoiesis, where stromal elements (e.g. fibroblasts and mesenchymal stem cells [MSCs]) work in concert to support blood cell development. However, the establishment of an abnormal clone can lead to a blood malignancy, such as acute myeloid leukaemia (AML). Despite our increased understanding of the pathophysiology of the disease, patient survival remains suboptimal, mainly driven by the development of therapy resistance. In this review, we highlight the importance of bone marrow fibroblasts and MSCs in health and acute myeloid leukaemia and their impact on patient prognosis. We discuss how stromal elements reduce the killing effects of therapies via a combination of contact-dependent (e.g. integrins) and contact-independent (i.e. secreted factors) mechanisms, accompanied by the establishment of an immunosuppressive microenvironment. Importantly, we underline the challenges of therapeutically targeting the bone marrow stroma to improve acute myeloid leukaemia patient outcomes, due to the inherent heterogeneity of stromal cell populations.
Miari, Katerina E.
Author
Sun, Jennifer and Corradini, Stefan and Azab, Feda and Shokeen, Monica and Muz, Barbara and Miari, Katerina E. and Maksimos, Mina and Diedrich, Camila and Asare, Obed and Alhallak, Kinan and Park, Chaelee and Lubben, Berit and Chen, Yixuan and Adebayo, Ola and Bash, Hannah and Kelley, Sarah and Fiala, Mark and Bender, Diane E. and Zhou, Haibin and Wang, Shaomeng and Vij, Ravi and Williams, Mark T. S. and Kareem Azab, Abdel (2024) IL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma. Leukemia, 38 (11). pp. 2355-2365. ISSN 0887-6924
Miari, Katerina E. and Williams, Mark T. S. (2024) Stromal bone marrow fibroblasts and mesenchymal stem cells support acute myeloid leukaemia cells and promote therapy resistance. British Journal of Pharmacology, 181 (2). pp. 216-237. ISSN 0007-1188
See full publications listWilliams, Mark T. S.
Author
Sun, Jennifer and Corradini, Stefan and Azab, Feda and Shokeen, Monica and Muz, Barbara and Miari, Katerina E. and Maksimos, Mina and Diedrich, Camila and Asare, Obed and Alhallak, Kinan and Park, Chaelee and Lubben, Berit and Chen, Yixuan and Adebayo, Ola and Bash, Hannah and Kelley, Sarah and Fiala, Mark and Bender, Diane E. and Zhou, Haibin and Wang, Shaomeng and Vij, Ravi and Williams, Mark T. S. and Kareem Azab, Abdel (2024) IL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma. Leukemia, 38 (11). pp. 2355-2365. ISSN 0887-6924
Miari, Katerina E. and Williams, Mark T. S. (2024) Stromal bone marrow fibroblasts and mesenchymal stem cells support acute myeloid leukaemia cells and promote therapy resistance. British Journal of Pharmacology, 181 (2). pp. 216-237. ISSN 0007-1188
See full publications listAvailable under License Creative Commons Attribution.
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