Skalka, George L. and Tsakovska, Mina and Murphy, Daniel (2024) Kinase signaling adaptation supports dysfunctional mitochondria in disease. Frontiers in Molecular Biosciences, 11: 1354682. ISSN 2296-889X
AI Summary:
Mitochondria play a critical role in maintaining tissue homeostasis. Dysregulation of mitochondrial function has been linked to cancer development. This review aims to explore how kinase signalling integrates with critical mitochondrial pathways and highlight areas for further investigation.AI Topics:
Mitochondria form a critical control nexus which are essential for maintaining correct tissue homeostasis. An increasing number of studies have identified dysregulation of mitochondria as a driver in cancer. However, which pathways support and promote this adapted mitochondrial function?
A key hallmark of cancer is perturbation of kinase signalling pathways. These pathways include mitogen activated protein kinases (MAPK), lipid secondary messenger networks, cyclic-AMP-activated (cAMP)/ AMP-activated kinases (AMPK), and Ca2+/calmodulin-dependent protein kinase (CaMK) networks. These signalling pathways have multiple substrates which support initiation and persistence of cancer. Many of these are involved in the regulation of mitochondrial morphology, mitochondrial apoptosis, mitochondrial calcium homeostasis, mitochondrial associated membranes (MAMs), and retrograde ROS signalling. This review will aim to both explore how kinase signalling integrates with these critical mitochondrial pathways and highlight how these systems can be usurped to support the development of disease. In addition, we will identify areas which require further investigation to fully understand the complexities of these regulatory interactions. Overall, this review will emphasize how studying the interaction between kinase signalling and mitochondria improves our understanding of mitochondrial homeostasis and can yield novel therapeutic targets to treat disease.
Skalka, George L.
Author
Vringer, Esmee and Heilig, Rosalie and Riley, Joel S. and Black, Annabel and Cloix, Catherine and Skalka, George and Montes-Gómez, Alfredo E. and Aguado, Aurore and Lilla, Sergio and Walczak, Henning and Gyrd-Hansen, Mads and Murphy, Daniel J. and Huang, Danny T. and Zanivan, Sara and Tait, Stephen W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43 (6). pp. 904-930. ISSN 0261-4189
Skalka, George L. and Tsakovska, Mina and Murphy, Daniel (2024) Kinase signaling adaptation supports dysfunctional mitochondria in disease. Frontiers in Molecular Biosciences, 11: 1354682. ISSN 2296-889X
See full publications listTsakovska, Mina
Author
Skalka, George L. and Tsakovska, Mina and Murphy, Daniel (2024) Kinase signaling adaptation supports dysfunctional mitochondria in disease. Frontiers in Molecular Biosciences, 11: 1354682. ISSN 2296-889X
See full publications listMurphy, Daniel
Author
Vincelette, Nicole D. and Yu, Xiaoqing and Kuykendall, Andrew T. and Moon, Jungwon and Su, Siyuan and Cheng, Chia- Ho and Sammut, Rinzine and Razabdouski, Tiffany N. and Nguyen, Hai Vu and Eksioglu, Erika A. and Chan, Onyee and Al Ali, Najla and Patel, Parth C. and Lee, Dae Hyun and Nakanishi, Shima and Ferreira, Renan B. and Mo, Qianxing and Cory, Suzanne and Lawrence, Harshani R. and Zhang, Ling and Murphy, Daniel J. and Komrokji, Rami S. and Lee, Daesung and Kaufmann, Scott H. and Cleveland, John L. and Yun, Seongseok (2024) Trisomy 8 defines a distinct subtype of myeloproliferative neoplasms driven by the MYC-alarmin axis. Blood Cancer Discovery, 5 (4). pp. 276-297. ISSN 2643-3230
Murphy, Daniel J. (2024) Investigating lung cancer using genetically engineered mouse models (GEMMS). Open Access Government, 42 (1). pp. 112-113. ISSN 2516-3817
Vringer, Esmee and Heilig, Rosalie and Riley, Joel S. and Black, Annabel and Cloix, Catherine and Skalka, George and Montes-Gómez, Alfredo E. and Aguado, Aurore and Lilla, Sergio and Walczak, Henning and Gyrd-Hansen, Mads and Murphy, Daniel J. and Huang, Danny T. and Zanivan, Sara and Tait, Stephen W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43 (6). pp. 904-930. ISSN 0261-4189
See full publications listAvailable under License Creative Commons Attribution.
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