Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Abstract

Background
Tumour-infiltrating CD8+ cytotoxic T cells confer favourable prognosis in colorectal cancer. The added prognostic value of other infiltrating immune cells is unclear and so we sought to investigate their prognostic value in two large clinical trial cohorts.
Methods
We used multiplex immunofluorescent staining of tissue microarrays to assess the densities of CD8+, CD20+, FoxP3+, and CD68+ cells in the intraepithelial and intrastromal compartments from tumour samples of patients with stage II–III colorectal cancer from the SCOT trial (ISRCTN59757862), which examined 3 months versus 6 months of adjuvant oxaliplatin-based chemotherapy, and from the QUASAR 2 trial (ISRCTN45133151), which compared adjuvant capecitabine with or without bevacizumab. Both trials included patients aged 18 years or older with an Eastern Cooperative Oncology Group performance status of 0–1. Immune marker predictors were analysed by multiple regression, and the prognostic and predictive values of markers for colorectal cancer recurrence-free interval by Cox regression were assessed using the SCOT cohort for discovery and QUASAR 2 cohort for validation.
Findings
After exclusion of cases without tissue microarrays and with technical failures, and following quality control, we included 2340 cases from the SCOT trial and 1069 from the QUASAR 2 trial in our analysis. Univariable analysis of associations with recurrence-free interval in cases from the SCOT trial showed a strong prognostic value of intraepithelial CD8 (CD8IE) as a continuous variable (hazard ratio [HR] for 75th vs 25th percentile [75vs25] 0·73 [95% CI 0·68–0·79], p=2·5 × 10−16), and of intrastromal FoxP3 (FoxP3IS; 0·71 [0·64–0·78], p=1·5 × 10−13) but not as strongly in the epithelium (FoxP3IE; 0·89 [0·84–0·96], p=1·5 × 10−4). Associations of other markers with recurrence-free interval were moderate. CD8IE and FoxP3IS retained independent prognostic value in bivariable and multivariable analysis, and, compared with either marker alone, a composite marker including both markers (CD8IE-FoxP3IS) was superior when assessed as a continuous variable (adjusted [a]HR75 vs 25 0·70 [95% CI 0·63–0·78], p=5·1 × 10−11) and when categorised into low, intermediate, and high density groups using previously published cutpoints (aHR for intermediate vs high 1·68 [95% CI 1·29–2·20], p=1·3 × 10−4; low vs high 2·58 [1·91–3·49], p=7·9 × 10−10), with performance similar to the gold-standard Immunoscore. The prognostic value of CD8IE-FoxP3IS was confirmed in cases from the QUASAR 2 trial, both as a continuous variable (aHR75 vs 25 0·84 [95% CI 0·73–0·96], p=0·012) and as a categorical variable for low versus high density (aHR 1·80 [95% CI 1·17–2·75], p=0·0071) but not for intermediate versus high (1·30 [0·89–1·88], p=0·17).
Interpretation
Combined evaluation of CD8IE and FoxP3IS could help to refine risk stratification in colorectal cancer. Investigation of FoxP3IS cells as an immunotherapy target in colorectal cancer might be merited.

People
Frei, Anja L.
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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McGuigan, Anthony
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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Sinha, Ritik R.A.K.
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Jabbar, Faiz
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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Gneo, Luciana
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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Tomasevic, Tijana
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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Iveson, Tim
Author

Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Saunders, Mark P.
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Oien, Karin A.
Author

Bouttell, Janet and Fraser, Heather and Goodlad, John R. and Hopkins, David and McKay, Pam and Oien, Karin A. and Seligmann, Bruce and Von Delft, Stephan and Hawkins, Neil (2024) Adding a gene expression profile test to aid differential diagnosis and treatment in aggressive large B-cell lymphoma: an early exploratory economic evaluation. Applied Health Economics and Health Policy, 22 (2). pp. 243-254. ISSN 1175-5652

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Maka, Noori
Author

Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377

Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X

Galbraith, Norman J. and Quinn, Jean A. and Al-Badran, Sara Sf and Pennel, Kathryn A.F. and Hillson, Lily V.S. and Hatthakarnkul, Phimmada and McKenzie, Molly and Maka, Noori and Loi, Lynette and Frixou, Mikaela and Steele, Colin W. and Roxburgh, Campbell S. and Horgan, Paul G. and McMillan, Donald C. and Edwards, Joanne (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48: 102064. ISSN 1944-7124

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Pezzella, Francesco
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Campo, Leticia
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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Browne, Molly
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Glaire, Mark
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Kildal, Wanja
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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Danielsen, Havard E.
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Hay, Jennifer
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Edwards, J.
Author

Thompson, Joshua J. and MacLeod, Nicholas and Will, Sarah and O'Rourke, Fraser and McGovern, Josh and Roxburgh, Campbell and Edwards, Joanne and Dolan, Ross D. and McMillan, Donald C. (2025) The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. BMC Cancer, 25: 543. ISSN 1471-2407

Dolan, Ross D. and Pennel, Kathryn and Thompson, Joshua and McKenzie, Molly and Alexander, Peter and Richards, Colin and Black, Douglas and Abbass, Tanvir and Maka, Noori and McGovern, Josh and Roseweir, Antonia and McSorley, Stephen T. and Horgan, Paul G. and Roxburgh, Campbell and McMillan, Donald C. and Edwards, Joanne (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3 (1): 7. ISSN 2731-9377

Pennel, Kathryn and Kurniawan, Ahmad and Al-Badran, Sara Samir Foad and Schubert Santana, Leonor and Quinn, Jean and Nixon, Colin and Hatthakarnkul, Phimmada and Maka, Noori and Roxburgh, Campbell and McMillan, Donald and Edwards, Joanne (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14 (12): 1629. ISSN 2218-273X

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Sansom, Owen
Author

Lu, Yuting and Travnickova, Jana and Badonyi, Mihaly and Rambow, Florian and Coates, Andrea and Khan, Zaid and Marques, Jair and Murphy, Laura C. and Garcia-Martinez, Pablo and Marais, Richard and Louphrasitthiphol, Pakavarin and Chan, Alex H.Y. and Schofield, Christopher J. and von Kriegsheim, Alex and Marsh, Joseph A. and Pavet, Valeria and Sansom, Owen J. and Illingworth, Robert S. and Patton, E. Elizabeth (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports, 43 (7): 114406. ISSN 2639-1856

Pereira, Brooke A. and Ritchie, Shona and Chambers, Cecilia R. and Gordon, Katie A. and Magenau, Astrid and Murphy, Kendelle J. and Nobis, Max and Tyma, Victoria M. and Liew, Ying Fei and Lucas, Morghan C. and Naeini, Marjan M. and Barkauskas, Deborah S. and Chacon-Fajardo, Diego and Howell, Anna E. and Parker, Amelia L. and Warren, Sean C. and Reed, Daniel A. and Lee, Victoria and Metcalf, Xanthe L. and Lee, Young Kyung and O'Regan, Luke P. and Zhu, Jessie and Trpceski, Michael and Fontaine, Angela R.M. and Stoehr, Janett and Rouet, Romain and Lin, Xufeng and Chitty, Jessica L. and Porazinski, Sean and Wu, Sunny Z. and Filipe, Elysse C. and Cadell, Antonia L. and Holliday, Holly and Yang, Jessica and Papanicolaou, Michael and Lyons, Ruth J. and Zaratzian, Anaiis and Tayao, Michael and Da Silva, Andrew and Vennin, Claire and Yin, Julia and Dew, Alysha B. and McMillan, Paul J. and Goldstein, Leonard D. and Deveson, Ira W. and Croucher, David R. and Samuel, Michael S. and Sim, Hao-Wen and Batten, Marcel and Chantrill, Lorraine and Grimmond, Sean M. and Gill, Anthony J. and Samra, Jaswinder and Evans, Thomas R. Jeffry and Sasaki, Takako and Phan, Tri G. and Swarbrick, Alexander and Sansom, Owen J. and Morton, Jennifer P. and Australian Pancreatic Cancer Matrix Atlas (APMA) and Australian Pancreatic Cancer Genome Initiative (APGI) and Pajic, Marina and Parker, Benjamin L. and Herrmann, David and Cox, Thomas R. and Timpson, Paul (2024) Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science Advances, 10 (27): eadl1197. ISSN 2375-2548

Malla, Sudhir B. and Byrne, Ryan M. and Lafarge, Maxime W. and Corry, Shania M. and Fisher, Natalie C. and Tsantoulis, Petros K. and Mills, Megan L. and Ridgway, Rachel A. and Lannagan, Tamsin R. M. and Najumudeen, Arafath K. and Gilroy, Kathryn L. and Amirkhah, Raheleh and Maguire, Sarah L. and Mulholland, Eoghan J. and Belnoue-Davis, Hayley L. and Grassi, Elena and Viviani, Marco and Rogan, Emily and Redmond, Keara L. and Sakhnevych, Svetlana and McCooey, Aoife J. and Bull, Courtney and Hoey, Emily and Sinevici, Nicoleta and Hall, Holly and Ahmaderaghi, Baharak and Domingo, Enric and Blake, Andrew and Richman, Susan D. and Isella, Claudio and Miller, Crispin and Bertotti, Andrea and Trusolino, Livio and Loughrey, Maurice B. and Kerr, Emma M. and Tejpar, Sabine and S:CORT Consortium and Maughan, Timothy S. and Lawler, Mark and Campbell, Andrew D. and Leedham, Simon J. and Koelzer, Viktor H. and Sansom, Owen J. and Dunne, Philip D. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56 (6): 1321. ISSN 1061-4036

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Kelly, Caroline
Author

Derby, Sarah and Jackson, Mark R. and Williams, Karin and Stobo, Jamie and Kelly, Caroline and Sweeting, Lorna and Shad, Shumaila and Herbert, Christopher and Short, Susan C. and Williamson, Aoife and James, Allan and Nowicki, Stefan and Bulbeck, Helen and Chalmers, Anthony (2024) Concurrent olaparib and radiotherapy in elderly patients with newly diagnosed glioblastoma: the phase I dose escalation PARADIGM trial. International Journal of Radiation Oncology, Biology, Physics, 118 (5). pp. 1371-1378. ISSN 0360-3016

Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Tomlinson, Ian
Author

Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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Kerr, Rachel
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Kerr, David
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

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Domingo, Enric
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

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TransSCOT consortium
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

See full publications list
Church, David N.
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik RAK and Glaire, Mark A. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Harkin, Andrea and Iveson, Tim J. and Saunders, Mark and Oein, Karin and Maka, Noori and Pezella, Francesco and Campo, Leticia and Hay, Jennifer and Edwards, Joanne and Sansom, Owen J. and Kelly, Caroline and Tomlinson, Ian and Kildal, Wanja and Kerr, Rachel S. and Kerr, David J. and Danielsen, Håvard E. and Domingo, Enric and Church, David N. and Koelzer, Viktor H. (2023) Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. Journal of Pathology: Clinical Research, 9 (6). pp. 449-463. ISSN 2056-4538

See full publications list
Koelze, Viktor H.
Author

Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H. (2024) Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis. Lancet Oncology, 25 (2). pp. 198-211. ISSN 1470-2045

See full publications list
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Title:
Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis
Creators:
Frei, Anja L. and McGuigan, Anthony and Sinha, Ritik R.A.K. and Jabbar, Faiz and Gneo, Luciana and Tomasevic, Tijana and Iveson, Tim and Saunders, Mark P. and Oien, Karin A. and Maka, Noori and Pezzella, Francesco and Campo, Leticia and Browne, Molly and Glaire, Mark and Kildal, Wanja and Danielsen, Havard E. and Hay, Jennifer and Edwards, Joanne and Sansom, Owen and Kelly, Caroline and Tomlinson, Ian and Kerr, Rachel and Kerr, David and Domingo, Enric and TransSCOT consortium and Church, David N. and Koelze, Viktor H.
Identification Number:
10.1016/S1470-2045(23)00560-0
Date:
February 2024
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Publisher:
Elsevier
Additional Information:
The SCOT trial was funded by the Medical Research Council (transferred to NETSCC–Efficacy and Mechanism Evaluation; grant number G0601705), the National Institute for Health and Care Research (NIHR) Health Technology Assessment (14/140/84), Cancer Research UK Core Clinical Trials Unit Glasgow funding (C6716/A9894), and the Swedish Cancer Society. The TransSCOT sample collection was funded by a Cancer Research UK Clinical Trials Awards and Advisory Committee—Sample Collection (C6716/A13941). The QUASAR 2 trial was funded by an unrestricted educational grant to DJK from Roche. This biomarker study was funded by the Oxford NIHR Comprehensive Biomedical Research Centre, a Cancer Research UK Advanced Clinician Scientist Fellowship (C26642/A27963) to DC, Cancer Research UK (award A25142) to the Cancer Research UK Glasgow Centre. VHK acknowledges funding by the Promedica Foundation (F-87701-41-01).
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URI:
https://pub.demo35.eprints-hosting.org/id/eprint/371
Item Type:
Article
Depositing User:
Unnamed user with email ejo1f20@soton.ac.uk
Date Deposited:
11 Jun 2025 16:37
Revision:
52
Last Modified:
11 Jun 2025 16:37
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