O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
AI Summary:
The study identified a transcriptome signature, RPLS, that can predict chemotherapy outcome in patients with advanced intrahepatic cholangiocarcinoma (iCCA). The signature was associated with altered tumour-myeloid dynamics and immune tolerogenicity.AI Topics:
Objective: Cytotoxic agents are the cornerstone of treatment for patients with advanced intrahepatic cholangiocarcinoma (iCCA), despite heterogeneous benefit. We hypothesised that the pretreatment molecular profiles of diagnostic biopsies can predict patient benefit from chemotherapy and define molecular bases of innate chemoresistance.
Design: We identified a cohort of advanced iCCA patients with comparable baseline characteristics who diverged as extreme outliers on chemotherapy (survival <6 m in rapid progressors, RP; survival >23 m in long survivors, LS). Diagnostic biopsies were characterised by digital pathology, then subjected to whole-transcriptome profiling of bulk and geospatially macrodissected tissue regions. Spatial transcriptomics of tumour-infiltrating myeloid cells was performed using targeted digital spatial profiling (GeoMx). Transcriptome signatures were evaluated in multiple cohorts of resected cancers. Signatures were also characterised using in vitro cell lines, in vivo mouse models and single cell RNA-sequencing data.
Results: Pretreatment transcriptome profiles differentiated patients who would become RPs or LSs on chemotherapy. Biologically, this signature originated from altered tumour-myeloid dynamics, implicating tumour-induced immune tolerogenicity with poor response to chemotherapy. The central role of the liver microenviroment was confrmed by the association of the RPLS transcriptome signature with clinical outcome in iCCA but not extrahepatic CCA, and in liver metastasis from colorectal cancer, but not in the matched primary bowel tumours.
Conclusions: The RPLS signature could be a novel metric of chemotherapy outcome in iCCA. Further development and validation of this transcriptomic signature is warranted to develop precision chemotherapy strategies in these settings.
O’Rourke, Colm J.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listSalati, Massimiliano
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listRae, Colin
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listCarpino, Guido
Author
Kendall, Timothy and Overi, Diletta and Guido, Maria and Braconi, Chiara and Banales, Jesus and Cardinale, Vincenzo and Gaudio, Eugenio and Groot Koerkamp, Bas and Carpino, Guido (2024) Recommendations on maximising the clinical value of tissue in the management of patients with intrahepatic cholangiocarcinoma. JHEP Reports, 6 (6): 101067. ISSN 2589-5559
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listLeslie, Holly
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
Shamis, Suad Ahmad Khalifa and Savioli, Francesca and Ammar, Aula and Al-Badran, Sara S.F. and Hatthakarnkul, Phimmada and Leslie, Holly and Mallon, Elizabeth and Jamieson, Nigel B. and McMillan, Donald C. and Edwards, Joanne (2024) Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay. Histology and Histopathology: Cellular and Molecular Biology, 39. pp. 177-200. ISSN 0213-3911
See full publications listPea, Antonio
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listPrete, Maria G.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listBonetti, L.R.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listAmato, Francesco
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listMontal, R.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listUpstill-Goddard, Rosie
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listNixon, Colin
Author
Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
Santi, Alice and Kay, Emily J. and Neilson, Lisa J. and McGarry, Lynn and Lilla, Sergio and Mullin, Margaret and Paul, Nikki R. and Fercoq, Frederic and Koulouras, Grigorios and Rodriguez Blanco, Giovanny and Athineos, Dimitris and Mason, Susan and Hughes, Mark and Thomson, Gemma and Kieffer, Yann and Nixon, Colin and Blyth, Karen and Mechta-Grigoriou, Fatima and Carlin, Leo M. and Zanivan, Sara (2024) Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. Science Signaling, 17 (827): eade0580. ISSN 1945-0877
See full publications listSanchon-Sanchez, Paula
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listKunderfranco, Paolo
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listSia, Daniela
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listGaudio, Eugenio
Author
Kendall, Timothy and Overi, Diletta and Guido, Maria and Braconi, Chiara and Banales, Jesus and Cardinale, Vincenzo and Gaudio, Eugenio and Groot Koerkamp, Bas and Carpino, Guido (2024) Recommendations on maximising the clinical value of tissue in the management of patients with intrahepatic cholangiocarcinoma. JHEP Reports, 6 (6): 101067. ISSN 2589-5559
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listOveri, Diletta
Author
Kendall, Timothy and Overi, Diletta and Guido, Maria and Braconi, Chiara and Banales, Jesus and Cardinale, Vincenzo and Gaudio, Eugenio and Groot Koerkamp, Bas and Carpino, Guido (2024) Recommendations on maximising the clinical value of tissue in the management of patients with intrahepatic cholangiocarcinoma. JHEP Reports, 6 (6): 101067. ISSN 2589-5559
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listCascinu, Stefano
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listHogdall, Dan
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listPugh, Sian
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listDomingo, Enric
Author
Malla, Sudhir B. and Byrne, Ryan M. and Lafarge, Maxime W. and Corry, Shania M. and Fisher, Natalie C. and Tsantoulis, Petros K. and Mills, Megan L. and Ridgway, Rachel A. and Lannagan, Tamsin R. M. and Najumudeen, Arafath K. and Gilroy, Kathryn L. and Amirkhah, Raheleh and Maguire, Sarah L. and Mulholland, Eoghan J. and Belnoue-Davis, Hayley L. and Grassi, Elena and Viviani, Marco and Rogan, Emily and Redmond, Keara L. and Sakhnevych, Svetlana and McCooey, Aoife J. and Bull, Courtney and Hoey, Emily and Sinevici, Nicoleta and Hall, Holly and Ahmaderaghi, Baharak and Domingo, Enric and Blake, Andrew and Richman, Susan D. and Isella, Claudio and Miller, Crispin and Bertotti, Andrea and Trusolino, Livio and Loughrey, Maurice B. and Kerr, Emma M. and Tejpar, Sabine and S:CORT Consortium and Maughan, Timothy S. and Lawler, Mark and Campbell, Andrew D. and Leedham, Simon J. and Koelzer, Viktor H. and Sansom, Owen J. and Dunne, Philip D. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56 (6): 1321. ISSN 1061-4036
Malla, Sudhir B. and Byrne, Ryan M. and Lafarge, Maxime W. and Corry, Shania M. and Fisher, Natalie C. and Tsantoulis, Petros K. and Mills, Megan L. and Ridgway, Rachel A. and Lannagan, Tamsin R. M. and Najumudeen, Arafath K. and Gilroy, Kathryn L. and Amirkhah, Raheleh and Maguire, Sarah L. and Mulholland, Eoghan J. and Belnoue-Davis, Hayley L. and Grassi, Elena and Viviani, Marco and Rogan, Emily and Redmond, Keara L. and Sakhnevych, Svetlana and McCooey, Aoife J. and Bull, Courtney and Hoey, Emily and Sinevici, Nicoleta and Hall, Holly and Ahmaderaghi, Baharak and Domingo, Enric and Blake, Andrew and Richman, Susan D. and Isella, Claudio and Miller, Crispin and Bertotti, Andrea and Trusolino, Livio and Loughrey, Maurice B. and Kerr, Emma M. and Tejpar, Sabine and S:CORT consortium and Maughan, Timothy S. and Lawler, Mark and Campbell, Andrew D. and Leedham, Simon J. and Koelzer, Viktor H. and Sansom, Owen J. and Dunne, Philip D. (2024) Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56 (3). pp. 458-472. ISSN 1061-4036
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listPrimrose, John N.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listBridgewater, John
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listSpallanzi, A.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listGelsomino, F.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listLlovet, J.M.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listCalvisi, Diego F.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listBoulter, Luke
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listCaputo, F.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listLleo, Ana
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listJamieson, Nigel B.
Author
MacDonald, Lucy and Elmesmari, Aziza and Somma, Domenico and Frew, Jack and Di Mario, Clara and Madhu, Roopa and Paoletti, Audrey and Simakou, Theodoros and Hardy, Olympia M. and Tolusso, Barbara and Campobasso, Denise and Perniola, Simone and Gessi, Marco and Gigante, Maria Rita and Petricca, Luca and Bruno, Dario and Coletto, Lavinia Agra and Benvenuto, Roberta and Isaacs, John D. and Filby, Andrew and McDonald, David and Sim, Jasmine P.X. and Jamieson, Nigel and Wei, Kevin and D’Agostino, Maria Antonietta and Millar, Neal L. and Milling, Simon and McSharry, Charles and Gremese, Elisa and Affleck, Karen and Baker, Kenneth F. and McInnes, Iain B. and Otto, Thomas D. and Korsunsky, Ilya and Alivernini, Stefano and Kurowska-Stolarska, Mariola (2024) Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis. Immunity, 57 (12). 2843-2862.e12. ISSN 1074-7613
Lucocq, James and Haugk, Beate and Parkinson, Daniel and Darne, Antony and Joseph, Nejo and Hawkyard, Jake and White, Steve and Mownah, Omar and Menon, Krishna and Furukawa, Takaki and Inoue, Yosuke and Hirose, Yuki and Sasahira, Naoki and Mittal, Anubhav and Samra, Jas and Sheen, Amy and Feretis, Michael and Balakrishnan, Anita and Ceresa, Carlo and Davidson, Brian and Pande, Rupaly and Dasari, Bobby V.M. and Tanno, Lulu and Karavias, Dimitrios and Helliwell, Jack and Young, Alistair and Nunes, Quentin and Urbonas, Tomas and Silva, Michael and Gordon-Weeks, Alex and Barrie, Jenifer and Gomez, Dhanny and van Laarhoven, Stijn and Nawara, Hossam and Doyle, Joseph and Bhogal, Ricky and Harrison, Ewen and Roalso, Marcus and Ciprani, Deborah and Aroori, Somaiah and Ratnayake, Bathiya and Koea, Jonathan and Capurso, Gabriele and Bellotti, Ruben and Stättner, Stefan and Alsaoudi, Tareq and Bhardwaj, Neil and Jeffery, Fraser and Connor, Saxon and Cameron, Andrew and Jamieson, Nigel and Roberts, Keith and Soreide, Kjetil and Gill, Anthony J. and Pandanaboyana, Sanjay (2024) Precursor epithelial subtypes of adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN): clinicopathological features, recurrence and response to adjuvant chemotherapy. Annals of Surgical Oncology, 31 (10). pp. 7023-7032. ISSN 1068-9265
McKenzie, Molly and Lian, Guang-Yu and Pennel, Kathryn A.F. and Quinn, Jean A. and Jamieson, Nigel B. and Edwards, Joanne (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10 (12): e32904. ISSN 2405-8440
See full publications listLuppi, G.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listDominici, M.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listAndersen, Jesper B.
Author
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listBraconi, Chiara
Author
Kendall, Timothy and Overi, Diletta and Guido, Maria and Braconi, Chiara and Banales, Jesus and Cardinale, Vincenzo and Gaudio, Eugenio and Groot Koerkamp, Bas and Carpino, Guido (2024) Recommendations on maximising the clinical value of tissue in the management of patients with intrahepatic cholangiocarcinoma. JHEP Reports, 6 (6): 101067. ISSN 2589-5559
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
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