Investigating lung cancer using genetically engineered mouse models (GEMMS) Daniel J. Murphy, Professor of Lung Cancer & Mesothelioma at the University of Glasgow, School of Cancer Sciences, discusses opportunities for improving cancer research and care through the use of genetically engineered mouse models. Despite changes in smoking habits, cancers of the lung remain the most lethal types of cancer in the UK and worldwide. In the UK, lung cancer accounts for over 20% of all deaths from cancer, claiming almost 35,000 victims annually (2017-2019 CRUK Lung Cancer Statistics). Until very recently, the vast majority of lung cancers were diagnosed at a late stage – meaning the cancers were very well established and at their most aggressive. Few of these cases respond effectively to treatment; when they do, responses are often short-lived.