Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
AI Summary:
The study evaluated the prevalence of cardiovascular risk factors, overt cardiovascular disease, and cardiac imaging abnormalities in patients treated with trastuzumab and anthracycline at least 5 years previously. The results showed that asymptomatic left ventricular systolic dysfunction, abnormal cardiac biomarkers, and cardiac risk factors were common even in those with normal LVEF on completion of treatment.AI Topics:
Objectives: Long-term follow-up of patients treated with trastuzumab largely focuses on those with reduced left ventricular ejection fraction (LVEF) on treatment completion. This study sought to evaluate the prevalence of cardiovascular risk factors, overt cardiovascular disease and cardiac imaging abnormalities using cardiac magnetic resonance (CMR), in participants with normal LVEF on completion of trastuzumab±anthracycline therapy at least 5 years previously.
Methods: Participants with human epidermal growth factor receptor 2-positive breast cancer treated with trastuzumab±anthracycline ≥5 years previously were identified from a clinical database. All participants had normal LVEF prior to, and on completion of, treatment. Participants underwent clinical cardiovascular evaluation, ECG, cardiac biomarker evaluation and CMR. Left ventricular systolic dysfunction (LVSD) was defined as LVEF <50%.
Results: Forty participants were recruited between 15 March 2021 and 19 July 2022. Median time since completion of trastuzumab was 7.8 years (range 5.9–10.8 years) and 90% received prior anthracycline. 25% of participants had LVSD; median LVEF was 55.2% (Q1–Q3, 51.3–61.2). 30% of participants had N-terminal pro-B-type natriuretic peptide >125 pg/mL and 8% had high-sensitivity cardiac troponin T >14 ng/L. 33% of participants had a new finding of hypertension. 58% had total cholesterol >5.0 mmol/L, 43% had triglycerides >1.7 mmol/L and 5% had a new diagnosis of diabetes.
Conclusions: The presence of asymptomatic LVSD, abnormal cardiac biomarkers and cardiac risk factors in participants treated with trastuzumab and anthracycline at least 5 years previously is common, even in those with normal LVEF on completion of treatment. Our findings reinforce the relevance of comprehensive evaluation of cardiovascular risk factors following completion of cancer therapy, in addition to LVEF assessment.
Glen, Claire
Author
Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
See full publications listMorrow, Andrew J.
Author
Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
Morrow, Andrew J. and Sykes, Robert and Saleh, Merna and Zahra, Baryab and MacIntosh, Alasdair and Kamdar, Anna and Bagot, Catherine and Bayes, Hannah K. and Blyth, Kevin G. and Bulluck, Heerajnarain and Carrick, David and Church, Colin and Corcoran, David and Findlay, Iain and Gibson, Vivienne and Gillespie, Lynsey and Grieve, Douglas and Hall Barrientos, Pauline and Ho, Antonia and Lang, Ninian N. and Lowe, David J. and Lennie, Vera and Macfarlane, Peter W. and Mayne, Kaitlin J. and Mark, Patrick B. and McConnachie, Alex and McGeoch, Ross and Nordin, Sabrina and Payne, Alexander and Rankin, Alastair J. and Robertson, Keith and Ryan, Nicola and Roditi, Giles and Sattar, Naveed and Stobo, David and Allwood-Spiers, Sarah and Touyz, Rhian M. and Veldtman, Gruschen and Weeden, Sarah and Weir, Robin and Watkins, Stuart and Welsh, Paul and Mangion, Kenneth and Berry, Colin (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4: 32. ISSN 2730-664X
See full publications listRoditi, Giles
Author
Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
Morrow, Andrew J. and Sykes, Robert and Saleh, Merna and Zahra, Baryab and MacIntosh, Alasdair and Kamdar, Anna and Bagot, Catherine and Bayes, Hannah K. and Blyth, Kevin G. and Bulluck, Heerajnarain and Carrick, David and Church, Colin and Corcoran, David and Findlay, Iain and Gibson, Vivienne and Gillespie, Lynsey and Grieve, Douglas and Hall Barrientos, Pauline and Ho, Antonia and Lang, Ninian N. and Lowe, David J. and Lennie, Vera and Macfarlane, Peter W. and Mayne, Kaitlin J. and Mark, Patrick B. and McConnachie, Alex and McGeoch, Ross and Nordin, Sabrina and Payne, Alexander and Rankin, Alastair J. and Robertson, Keith and Ryan, Nicola and Roditi, Giles and Sattar, Naveed and Stobo, David and Allwood-Spiers, Sarah and Touyz, Rhian M. and Veldtman, Gruschen and Weeden, Sarah and Weir, Robin and Watkins, Stuart and Welsh, Paul and Mangion, Kenneth and Berry, Colin (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4: 32. ISSN 2730-664X
See full publications listHopkins, Tracey
Author
Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
See full publications listMacpherson, Iain R.
Author
Maldonado, Horacio and Dreger, Marcel and Bedgood, Lara D. and Kyriakou, Theano and Wolanska, Katarzyna I. and Rigby, Megan E. and Marotta, Valeria E. and Webster, Justine M. and Wang, Jun and Rusilowicz-Jones, Emma V. and Marshall, John F. and Coulson, Judy M. and MacPherson, Iain R. and Hurlstone, Adam and Morgan, Mark R. (2024) A trafficking regulatory subnetwork governs α V β 6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance. Science Advances, 10 (49): eadk9944. ISSN 2375-2548
Hanna, Daire and Merrick, Sophie and Ghose, Aruni and Devlin, Michael John and Yang, Dorothy D. and Phillips, Edward and Okines, Alicia and Chopra, Neha and Papadimatraki, Elisavet and ROSS, KIRSTY and MacPherson, Iain and Boh, Zhuang Y. and Michie, Caroline O. and Swampillai, Angela and Gupta, Sunnia and Robinson, Tim and Germain, Lewis and Twelves, Chris and Atkinson, Charlotte and Konstantis, Apostolos and Riddle, Pippa and Cresti, Nicola and Naik, Jay D. and Borley, Annabel and Guppy, Amy and Schmid, Peter and Phillips, Melissa (2024) Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom. British Journal of Cancer, 130 (12). pp. 1916-1920. ISSN 0007-0920
Agnew, Sommer and Crawford, Megan and MacPherson, Iain and Shiramizu, Victor and Fleming, Leanne (2024) The impact of symptom clusters on endocrine therapy adherence in patients with breast cancer. Breast, 75: 103731. ISSN 0960-9776
See full publications listStewart, Philip
Author
Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
See full publications listPetrie, Mark C.
Author
Rankin, Stephen and Fountain, Caitlin and Gemmell, Alastair J. and Quinn, Daire and Henderson, Alasdair and McClure, John and Small, Sandy and Venugopal, Balaji and McKay, Pamela and Slomka, Piotr J. and Colville, David and Petrie, Mark C. and Meléndez, Giselle C. and Lang, Ninian N. (2025) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients. Clinical Science, 139 (1). pp. 29-41. ISSN 0143-5221
Rankin, Stephen and Fountain, Caitlin and Gemmell, Alastair and Quinn, Daire and Henderson, Alasdair and McClure, John and Small, Sandy and Venugopal, Balaji and McKay, Pamela and Slomka, Piotr J. and Colville, David and Petrie, Mark C. and Meléndez, Giselle C. and Lang, Ninian N. (2024) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients using 18F-FDG positron emission tomography. bioRxiv.
Rankin, Stephen and Elyan, Benjamin and Jones, Robert and Venugopal, Balaji and Mark, Patrick B. and Lees, Jennifer S. and Petrie, Mark C. and Lang, Ninian N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6 (2). pp. 267-279. ISSN 2666-0873
See full publications listBerry, Colin
Author
Elbassioni, Ali Ali Mohamed and Raheem, Anmar A. and Song, Jian and Johnston, Alexander S. and Trivett, Cara and Lin, Hong and Zhang, Haobo and Bradley, Ashley and Higgins, Erin and Mooney, Leanne and Koay, Yen Chin and O'Toole, Dylan and Herzyk, Pawel and Nixon, Colin and Blyth, Karen and O'Sullivan, John F. and Lang, Ninian N. and Berry, Colin and Braun, Thomas and Schiattarella, Gabriele G. and Giacca, Mauro and McBride, Martin W. and Nicklin, Stuart A. and Cameron, Ewan R. and Loughrey, Christopher M. and MacDonald, Eilidh A. (2025) Targeting Runx1 protects against heart failure with preserved ejection fraction. bioRxiv.
Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
Morrow, Andrew J. and Sykes, Robert and Saleh, Merna and Zahra, Baryab and MacIntosh, Alasdair and Kamdar, Anna and Bagot, Catherine and Bayes, Hannah K. and Blyth, Kevin G. and Bulluck, Heerajnarain and Carrick, David and Church, Colin and Corcoran, David and Findlay, Iain and Gibson, Vivienne and Gillespie, Lynsey and Grieve, Douglas and Hall Barrientos, Pauline and Ho, Antonia and Lang, Ninian N. and Lowe, David J. and Lennie, Vera and Macfarlane, Peter W. and Mayne, Kaitlin J. and Mark, Patrick B. and McConnachie, Alex and McGeoch, Ross and Nordin, Sabrina and Payne, Alexander and Rankin, Alastair J. and Robertson, Keith and Ryan, Nicola and Roditi, Giles and Sattar, Naveed and Stobo, David and Allwood-Spiers, Sarah and Touyz, Rhian M. and Veldtman, Gruschen and Weeden, Sarah and Weir, Robin and Watkins, Stuart and Welsh, Paul and Mangion, Kenneth and Berry, Colin (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4: 32. ISSN 2730-664X
See full publications listEpstein, Frederick
Author
Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
See full publications listLang, Ninian N.
Author
Elyan, Benjamin M.P. and Tan, Beatrix and Lambourg, Emilie and McAllister, David A. and Jones, Rob J. and Lang, Ninian N. and Mark, Patrick B. and Lees, Jennifer S. and Bell, Samira (2025) Incidence of cancer in people with CKD not requiring kidney replacement therapy: a systematic review and meta-analysis. Clinical Kidney Journal, 18 (5): sfaf084. ISSN 2048-8505
Elbassioni, Ali Ali Mohamed and Raheem, Anmar A. and Song, Jian and Johnston, Alexander S. and Trivett, Cara and Lin, Hong and Zhang, Haobo and Bradley, Ashley and Higgins, Erin and Mooney, Leanne and Koay, Yen Chin and O'Toole, Dylan and Herzyk, Pawel and Nixon, Colin and Blyth, Karen and O'Sullivan, John F. and Lang, Ninian N. and Berry, Colin and Braun, Thomas and Schiattarella, Gabriele G. and Giacca, Mauro and McBride, Martin W. and Nicklin, Stuart A. and Cameron, Ewan R. and Loughrey, Christopher M. and MacDonald, Eilidh A. (2025) Targeting Runx1 protects against heart failure with preserved ejection fraction. bioRxiv.
Rankin, Stephen and Fountain, Caitlin and Gemmell, Alastair J. and Quinn, Daire and Henderson, Alasdair and McClure, John and Small, Sandy and Venugopal, Balaji and McKay, Pamela and Slomka, Piotr J. and Colville, David and Petrie, Mark C. and Meléndez, Giselle C. and Lang, Ninian N. (2025) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients. Clinical Science, 139 (1). pp. 29-41. ISSN 0143-5221
See full publications listMangion, Kenneth
Author
Glen, Claire and Morrow, Andrew and Roditi, Giles and Hopkins, Tracey and Macpherson, Iain and Stewart, Philip and Petrie, Mark C. and Berry, Colin and Epstein, Frederick and Lang, Ninian N. and Mangion, Kenneth (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110 (9). pp. 650-656. ISSN 1355-6037
Morrow, Andrew J. and Sykes, Robert and Saleh, Merna and Zahra, Baryab and MacIntosh, Alasdair and Kamdar, Anna and Bagot, Catherine and Bayes, Hannah K. and Blyth, Kevin G. and Bulluck, Heerajnarain and Carrick, David and Church, Colin and Corcoran, David and Findlay, Iain and Gibson, Vivienne and Gillespie, Lynsey and Grieve, Douglas and Hall Barrientos, Pauline and Ho, Antonia and Lang, Ninian N. and Lowe, David J. and Lennie, Vera and Macfarlane, Peter W. and Mayne, Kaitlin J. and Mark, Patrick B. and McConnachie, Alex and McGeoch, Ross and Nordin, Sabrina and Payne, Alexander and Rankin, Alastair J. and Robertson, Keith and Ryan, Nicola and Roditi, Giles and Sattar, Naveed and Stobo, David and Allwood-Spiers, Sarah and Touyz, Rhian M. and Veldtman, Gruschen and Weeden, Sarah and Weir, Robin and Watkins, Stuart and Welsh, Paul and Mangion, Kenneth and Berry, Colin (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4: 32. ISSN 2730-664X
See full publications listAvailable under License Creative Commons Attribution.
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