Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease for which better therapies are urgently needed. Fibroblasts and macrophages are heterogeneous cell populations able to enhance metastasis, but the role of a macrophage-fibroblast crosstalk in regulating their pro-metastatic functions remains poorly understood. Here we deconvolve how macrophages regulate metastasis-associated fibroblast (MAF) heterogeneity in the liver. We identify three functionally distinct MAF populations, among which the generation of pro-metastatic and immunoregulatory myofibroblastic-MAFs (myMAFs) critically depends on macrophages. Mechanistically, myMAFs are induced through a STAT3-dependent mechanism driven by macrophage-derived progranulin and cancer cell-secreted leukaemia inhibitory factor (LIF). In a reciprocal manner, myMAF secreted osteopontin promotes an immunosuppressive macrophage phenotype resulting in the inhibition of cytotoxic T cell functions. Pharmacological blockade of STAT3 or myMAF-specific genetic depletion of STAT3 restores an anti-tumour immune response and reduces metastases. Our findings provide molecular insights into the complex macrophage–fibroblast interactions in tumours and reveal potential targets to inhibit PDAC liver metastasis.

People
Raymant, Meirion
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Astuti, Yuliana
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Alvaro-Espinosa, Laura
Author

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Green, Daniel
Author

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Quaranta, Valeria
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Bellomo, Gaia
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Glenn, Mark
Author

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Chandran-Gorner, Vatshala
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Palmer, Daniel H.
Author

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Halloran, Christopher
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Ghaneh, Paula
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Henderson, Neil C.
Author

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Morton, Jennifer P.
Author

Pereira, Brooke A. and Ritchie, Shona and Chambers, Cecilia R. and Gordon, Katie A. and Magenau, Astrid and Murphy, Kendelle J. and Nobis, Max and Tyma, Victoria M. and Liew, Ying Fei and Lucas, Morghan C. and Naeini, Marjan M. and Barkauskas, Deborah S. and Chacon-Fajardo, Diego and Howell, Anna E. and Parker, Amelia L. and Warren, Sean C. and Reed, Daniel A. and Lee, Victoria and Metcalf, Xanthe L. and Lee, Young Kyung and O'Regan, Luke P. and Zhu, Jessie and Trpceski, Michael and Fontaine, Angela R.M. and Stoehr, Janett and Rouet, Romain and Lin, Xufeng and Chitty, Jessica L. and Porazinski, Sean and Wu, Sunny Z. and Filipe, Elysse C. and Cadell, Antonia L. and Holliday, Holly and Yang, Jessica and Papanicolaou, Michael and Lyons, Ruth J. and Zaratzian, Anaiis and Tayao, Michael and Da Silva, Andrew and Vennin, Claire and Yin, Julia and Dew, Alysha B. and McMillan, Paul J. and Goldstein, Leonard D. and Deveson, Ira W. and Croucher, David R. and Samuel, Michael S. and Sim, Hao-Wen and Batten, Marcel and Chantrill, Lorraine and Grimmond, Sean M. and Gill, Anthony J. and Samra, Jaswinder and Evans, Thomas R. Jeffry and Sasaki, Takako and Phan, Tri G. and Swarbrick, Alexander and Sansom, Owen J. and Morton, Jennifer P. and Australian Pancreatic Cancer Matrix Atlas (APMA) and Australian Pancreatic Cancer Genome Initiative (APGI) and Pajic, Marina and Parker, Benjamin L. and Herrmann, David and Cox, Thomas R. and Timpson, Paul (2024) Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science Advances, 10 (27): eadl1197. ISSN 2375-2548

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

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Valiente, Manuel
Author

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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Mielgo, Ainhoa
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P and Campbell, Fiona and Pollard, Jeffrey W and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C (2024) Author correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5: 808. ISSN 2662-1347

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

See full publications list
Schmid, Michael C.
Author

Astuti, Yuliana and Raymant, Meirion and Quaranta, Valeria and Clarke, Kim and Abudula, Maidinaimu and Smith, Olivia and Bellomo, Gaia and Chandran-Gorner, Vatshala and Nourse, Craig and Halloran, Christopher and Ghaneh, Paula and Palmer, Daniel and Jones, Robert P. and Campbell, Fiona and Pollard, Jeffrey W. and Morton, Jennifer P. and Mielgo, Ainhoa and Schmid, Michael C. (2024) Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nature Cancer, 5. pp. 774-790. ISSN 2662-1347

Raymant, Meirion and Astuti, Yuliana and Alvaro-Espinosa, Laura and Green, Daniel and Quaranta, Valeria and Bellomo, Gaia and Glenn, Mark and Chandran-Gorner, Vatshala and Palmer, Daniel H. and Halloran, Christopher and Ghaneh, Paula and Henderson, Neil C. and Morton, Jennifer P. and Valiente, Manuel and Mielgo, Ainhoa and Schmid, Michael C. (2024) Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer. Nature Communications, 15: 3593. ISSN 2041-1723

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