Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
AI Summary:
The last decade has seen rapid progress in the use of genomic tests, including gene panels, whole-exome sequencing, and whole-genome sequencing. These advances have created expansive opportunities to characterize the molecular attributes of cancer, revealing a subset of cancer-associated aberrations called driver mutations.AI Topics:
The last decade has seen rapid progress in the use of genomic tests, including gene panels, whole‐exome sequencing, and whole‐genome sequencing, in research and clinical cancer care. These advances have created expansive opportunities to characterize the molecular attributes of cancer, revealing a subset of cancer‐associated aberrations called driver mutations. The identification of these driver mutations can unearth vulnerabilities of cancer cells to targeted therapeutics, which has led to the development and approval of novel diagnostics and personalized interventions in various malignancies. The applications of this modern approach, often referred to as precision oncology or precision cancer medicine, are already becoming a staple in cancer care and will expand exponentially over the coming years. Although genomic tests can lead to better outcomes by informing cancer risk, prognosis, and therapeutic selection, they remain underutilized in routine cancer care. A contributing factor is a lack of understanding of their clinical utility and the difficulty of results interpretation by the broad oncology community. Practical guidelines on how to interpret and integrate genomic information in the clinical setting, addressed to clinicians without expertise in cancer genomics, are currently limited. Building upon the genomic foundations of cancer and the concept of precision oncology, the authors have developed practical guidance to aid the interpretation of genomic test results that help inform clinical decision making for patients with cancer. They also discuss the challenges that prevent the wider implementation of precision oncology.
Casolino, Raffaella
Author
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723
See full publications listBeer, Philip A.
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listChakravarty, Debyani
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listDavis, Melissa B.
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listMalapelle, Umberto
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listMazzarella, Luca
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listNormanno, Nicola
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listPauli, Chantal
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listSubbiah, Vivek
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listTurnbull, Clare
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listWestphalen, C. Benedikt
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
See full publications listBiankin, Andrew
Author
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
Cooke, Sean F. and Wright, Thomas A. and Sin, Yuan Yan and Ling, Jiayue and Kyurkchieva, Elka and Phanthaphol, Nattaporn and McSkimming, Thomas and Herbert, Katharine and Rebus, Selma and Biankin, Andrew V. and Chang, David K. and Baillie, George S. and Blair, Connor M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14: 8998. ISSN 2045-2322
Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723
See full publications listAvailable under License Creative Commons Attribution Non-commercial No Derivatives.
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