Borland, Gillian and Wilkie, Stephen E. and Thomson, Jackie and Wang, Zhe and Tullett, Jennifer M.A. and Alic, Nazif and Selman, Colin (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23 (5): e14141. ISSN 1474-9718
AI Summary:
This study investigates the role of Pol III in mammalian ageing using C57BL6N mice heterozygous for Pol III. The results show that female Polr3b mice have improved bone health during ageing, but their ability to maintain an effective gut barrier function is compromised and they are susceptible to idiopathic dermatitis ID.AI Topics:
The genetic pathways that modulate ageing in multicellular organisms are typically highly conserved across wide evolutionary distances. Recently RNA polymerase III (Pol III) was shown to promote ageing in yeast, C. elegans and D. melanogaster. In this study we investigated the role of Pol III in mammalian ageing using C57BL/6N mice heterozygous for Pol III (Polr3b+/−). We identified sexually dimorphic, organ-specific beneficial as well as detrimental effects of the Polr3b+/− mutation on health. Female Polr3b+/− mice displayed improved bone health during ageing, but their ability to maintain an effective gut barrier function was compromised and they were susceptible to idiopathic dermatitis (ID). In contrast, male Polr3b+/− mice were lighter than wild-type (WT) males and had a significantly improved gut barrier function in old age. Several metabolic parameters were affected by both age and sex, but no genotype differences were detected. Neither male nor female Polr3b+/− mice were long-lived compared to WT controls. Overall, we find no evidence that a reduced Pol III activity extends mouse lifespan but we do find some potential organ- and sex-specific benefits for old-age health.
Borland, Gillian
Author
Borland, Gillian and Wilkie, Stephen E. and Thomson, Jackie and Wang, Zhe and Tullett, Jennifer M.A. and Alic, Nazif and Selman, Colin (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23 (5): e14141. ISSN 1474-9718
See full publications listWilkie, Stephen E.
Author
Borland, Gillian and Wilkie, Stephen E. and Thomson, Jackie and Wang, Zhe and Tullett, Jennifer M.A. and Alic, Nazif and Selman, Colin (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23 (5): e14141. ISSN 1474-9718
See full publications listThomson, Jackie
Author
Borland, Gillian and Wilkie, Stephen E. and Thomson, Jackie and Wang, Zhe and Tullett, Jennifer M.A. and Alic, Nazif and Selman, Colin (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23 (5): e14141. ISSN 1474-9718
See full publications listWang, Zhe
Author
Borland, Gillian and Wilkie, Stephen E. and Thomson, Jackie and Wang, Zhe and Tullett, Jennifer M.A. and Alic, Nazif and Selman, Colin (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23 (5): e14141. ISSN 1474-9718
See full publications listTullett, Jennifer M.A.
Author
Borland, Gillian and Wilkie, Stephen E. and Thomson, Jackie and Wang, Zhe and Tullett, Jennifer M.A. and Alic, Nazif and Selman, Colin (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23 (5): e14141. ISSN 1474-9718
See full publications listAlic, Nazif
Author
Borland, Gillian and Wilkie, Stephen E. and Thomson, Jackie and Wang, Zhe and Tullett, Jennifer M.A. and Alic, Nazif and Selman, Colin (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23 (5): e14141. ISSN 1474-9718
See full publications listSelman, Colin
Author
Borland, Gillian and Wilkie, Stephen E. and Thomson, Jackie and Wang, Zhe and Tullett, Jennifer M.A. and Alic, Nazif and Selman, Colin (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23 (5): e14141. ISSN 1474-9718
See full publications listAvailable under License Creative Commons Attribution.
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