Ahmed Hassan Elshiekh, Asma and Tait, Stephen W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18 (5). pp. 1054-1057. ISSN 1574-7891
AI Summary:
Mitochondrial metabolism and electron transport chain ETC function are essential for tumour proliferation and metastasis. Modulating mitochondrial electron flow to enhance tumour immunogenicity provides an exciting new therapeutic avenue.AI Topics:
Mitochondrial metabolism and electron transport chain (ETC) function are essential for tumour proliferation and metastasis. However, the impact of ETC function on cancer immunogenicity is not well understood. In a recent study, Mangalhara et al. found that inhibition of complex II leads to enhanced tumour immunogenicity, T‐cell‐mediated cytotoxicity and inhibition of tumour growth. Surprisingly, this antitumour effect is mediated by succinate accumulation affecting histone methylation. Histone methylation promotes the transcriptional upregulation of major histocompatibility complex–antigen processing and presentation (MHC‐APP) genes in a manner independent of interferon signalling. Modulating mitochondrial electron flow to enhance tumour immunogenicity provides an exciting new therapeutic avenue and may be particularly attractive for tumours with reduced expression of MHC‐APP genes or dampened interferon signalling.
Ahmed Hassan Elshiekh, Asma
Author
Ahmed Hassan Elshiekh, Asma and Tait, Stephen W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18 (5). pp. 1054-1057. ISSN 1574-7891
See full publications listTait, Stephen W.G.
Author
Hall-Younger, Ella and Tait, Stephen W.G. (2025) Mitochondria and cell death signalling. Current Opinion in Cell Biology, 94: 102510. ISSN 0955-0674
Ahmed Hassan Elshiekh, Asma and Tait, Stephen W.G. (2024) Tumour immunogenicity goes with the (mitochondrial electron) flow. Molecular Oncology, 18 (5). pp. 1054-1057. ISSN 1574-7891
Vringer, Esmee and Heilig, Rosalie and Riley, Joel S. and Black, Annabel and Cloix, Catherine and Skalka, George and Montes-Gómez, Alfredo E. and Aguado, Aurore and Lilla, Sergio and Walczak, Henning and Gyrd-Hansen, Mads and Murphy, Daniel J. and Huang, Danny T. and Zanivan, Sara and Tait, Stephen W.G. (2024) Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response. EMBO Journal, 43 (6). pp. 904-930. ISSN 0261-4189
See full publications listAvailable under License Creative Commons Attribution.
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