Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
AI Summary:
The study analyzed the first 2-year activity of a centralized West-of-Scotland-BTC clinic. The results showed that about 30% of patients with biliary tract cancers (BTC) were eligible for curative surgery. Additionally, the study found that reflex genomic profiling may not be cost-effective until molecularly driven strategies are limited to second-line settings.AI Topics:
Background:
With the increasing of novel therapeutics for the treatment of Biliary Tract Cancers (BTC), and the need to assess their socio-economic impacts for national licence approvals, it is as important as ever to have real-life data in national populations.
Methods and results:
We performed an audit of the first 2 year-activity (Sep 2019-Sep 2021) of the centralized West-of-Scotland-BTC clinic. 122 patients accessed the service, including 68% with cholangiocarcinoma (CCA), 27% with gallbladder cancer (GBC), and 5% with ampulla of Vater carcinoma with biliary phenotype (AVC). Median age at diagnosis was 66 (28–84), with 30% of newly diagnosed patients being younger than 60 years-old. Thirty-five cases (29%) underwent surgery, followed by adjuvant-chemotherapy in 66%. 60% had recurrent disease (80% with distant relapse). Sixty-four patients (58%) started first-line Systemic-AntiCancer-Treatment (SACT). Of these, 37% received second line SACT, the majority of which had iCCA and GBC. Thirty-% of those who progressed received third line SACT.
Conclusions:
About 30% of BTC were eligible for curative surgery. Fifty-eight and twenty% of the overall cohort of advanced BTC patients received first and second line SACT. Our data suggest that reflex genomic profiling may not be cost-effective until molecularly driven strategies are limited to second line setting.
Zanuso, Valentina
Author
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
See full publications listNash, Tamsin
Author
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
See full publications listCasolino, Raffaella
Author
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
Casolino, Raffaella and Beer, Philip A. and Chakravarty, Debyani and Davis, Melissa B. and Malapelle, Umberto and Mazzarella, Luca and Normanno, Nicola and Pauli, Chantal and Subbiah, Vivek and Turnbull, Clare and Westphalen, C. Benedikt and Biankin, Andrew V. (2024) Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance. CA: A Cancer Journal for Clinicians, 74 (3). pp. 264-285. ISSN 0007-9235
Agostini, Antonio and Piro, Geny and Inzani, Frediano and Quero, Giuseppe and Esposito, Annachiara and Caggiano, Alessia and Priori, Lorenzo and Larghi, Alberto and Alfieri, Sergio and Casolino, Raffaella and Scaglione, Giulia and Tondolo, Vincenzo and Cammarota, Giovanni and Ianiro, Gianluca and Corbo, Vincenzo and Biankin, Andrew V. and Tortora, Giampaolo and Carbone, Carmine (2024) Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. Nature Communications, 15 (1): 2764. ISSN 2041-1723
See full publications listArmstrong, Gregory
Author
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
See full publications listPallise, Ona
Author
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
See full publications listMilne, Jen
Author
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
See full publications listBraconi, Chiara
Author
Kendall, Timothy and Overi, Diletta and Guido, Maria and Braconi, Chiara and Banales, Jesus and Cardinale, Vincenzo and Gaudio, Eugenio and Groot Koerkamp, Bas and Carpino, Guido (2024) Recommendations on maximising the clinical value of tissue in the management of patients with intrahepatic cholangiocarcinoma. JHEP Reports, 6 (6): 101067. ISSN 2589-5559
Zanuso, Valentina and Nash, Tamsin and Casolino, Raffaella and Armstrong, Gregory and Pallise, Ona and Milne, Jen and Braconi, Chiara (2024) Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic. BMC Cancer, 24 (1): 597. ISSN 1471-2407
O’Rourke, Colm J. and Salati, Massimiliano and Rae, Colin and Carpino, Guido and Leslie, Holly and Pea, Antonio and Prete, Maria G. and Bonetti, L.R. and Amato, Francesco and Montal, R. and Upstill-Goddard, Rosie and Nixon, Colin and Sanchon-Sanchez, Paula and Kunderfranco, Paolo and Sia, Daniela and Gaudio, Eugenio and Overi, Diletta and Cascinu, Stefano and Hogdall, Dan and Pugh, Sian and Domingo, Enric and Primrose, John N. and Bridgewater, John and Spallanzi, A. and Gelsomino, F. and Llovet, J.M. and Calvisi, Diego F. and Boulter, Luke and Caputo, F. and Lleo, Ana and Jamieson, Nigel B. and Luppi, G. and Dominici, M. and Andersen, Jesper B. and Braconi, Chiara (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73 (3). pp. 496-508. ISSN 0017-5749
See full publications listAvailable under License Creative Commons Attribution.
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