Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

Abstract

Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug development2, highlighting an urgent need to better understand disease mechanisms. Here we show how functional genomics could address this challenge. By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3–6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. Genes regulated by ETS2 were prominently expressed in diseased tissues and more enriched for inflammatory bowel disease GWAS hits than most previously described pathways. Overexpressing ETS2 in resting macrophages reproduced the inflammatory state observed in chr21q22-associated diseases, with upregulation of multiple drug targets, including TNF and IL-23. Using a database of cellular signatures7, we identified drugs that might modulate this pathway and validated the potent anti-inflammatory activity of one class of small molecules in vitro and ex vivo. Together, this illustrates the power of functional genomics, applied directly in primary human cells, to identify immune-mediated disease mechanisms and potential therapeutic opportunities.

People
Stankey, C.T.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Bourges, C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Haag, L.M.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Turner-Stokes, T.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Piedade, A.P.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Palmer-Jones, C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Papa, I.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Silva dos Santos, M.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Zhang, Q.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

Beach, Callum and MacLean, David and Majorova, Dominika and Melemenidis, Stavros and Nambiar, Dhanya K. and Kim, Ryan K. and Valbuena, Gabriel N. and Guglietta, Silvia and Krieg, Carsten and Darvish, Damavandi Mahnaz and Suwa, Tatsuya and Easton, Alistair and Hillson, Lily V.S. and McCulloch, Ashley K. and McMahon, Ross K. and Pennel, Kathryn and Edwards, Joanne and O'Cathail, Sean M. and Roxburgh, Campbell S. and Domingo, Enric and Moon, Eui Jung and Jiang, Dadi and Jiang, Yanyan and Zhang, Q. and Koong, Albert C. and Woodruff, Trent M. and Graves, Edward E. and Maughan, Tim and Buczacki, Simon J.A. and Stucki, Manuel and Le, Quynh-Thu and Leedham, Simon J. and Giaccia, Amato J. and Olcina, Monica M. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133 (23): e168277. ISSN 0021-9738

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Cameron, A.
Author

Lucocq, James and Haugk, Beate and Parkinson, Daniel and Darne, Antony and Joseph, Nejo and Hawkyard, Jake and White, Steve and Mownah, Omar and Menon, Krishna and Furukawa, Takaki and Inoue, Yosuke and Hirose, Yuki and Sasahira, Naoki and Mittal, Anubhav and Samra, Jas and Sheen, Amy and Feretis, Michael and Balakrishnan, Anita and Ceresa, Carlo and Davidson, Brian and Pande, Rupaly and Dasari, Bobby V.M. and Tanno, Lulu and Karavias, Dimitrios and Helliwell, Jack and Young, Alistair and Nunes, Quentin and Urbonas, Tomas and Silva, Michael and Gordon-Weeks, Alex and Barrie, Jenifer and Gomez, Dhanny and van Laarhoven, Stijn and Nawara, Hossam and Doyle, Joseph and Bhogal, Ricky and Harrison, Ewen and Roalso, Marcus and Ciprani, Deborah and Aroori, Somaiah and Ratnayake, Bathiya and Koea, Jonathan and Capurso, Gabriele and Bellotti, Ruben and Stättner, Stefan and Alsaoudi, Tareq and Bhardwaj, Neil and Jeffery, Fraser and Connor, Saxon and Cameron, Andrew and Jamieson, Nigel and Roberts, Keith and Soreide, Kjetil and Gill, Anthony J. and Pandanaboyana, Sanjay (2024) Precursor epithelial subtypes of adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN): clinicopathological features, recurrence and response to adjuvant chemotherapy. Annals of Surgical Oncology, 31 (10). pp. 7023-7032. ISSN 1068-9265

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

Lucocq, James and Hawkyard, Jake and Haugk, Beate and Mownah, Omar and Menon, Krishna and Furukawa, Takaki and Inoue, Yosuke and Hirose, Yuki and Sasahira, Naoki and Feretis, Michael and Balakrishnan, Anita and Ceresa, Carlo and Davidson, Brian and Pande, Rupaly and Dasari, Bobby and Tanno, Lulu and Karavias, Dimitrios and Helliwell, Jack and Young, Alistair and Nunes, Quentin and Urbonas, Tomas and Silva, Michael and Gordon-Weeks, Alex and Barrie, Jenifer and Gomez, Dhanny and Van Laarhoven, Stijn and Robertson, Francis and Nawara, Hossain and Doyle, Joseph and Bhogal, Ricky and Harrison, Ewen and Roalso, Marcus and Ciprani, Debora and Aroori, Somaiah and Ratnayake, Bathiya and Koea, Jonathan and Capurso, Gabriele and Bellotti, Ruben and Stättner, Stefan and Alsaoudi, Tareq and Bhardwaj, Neil and Rajesh, Srujan and Jeffery, Fraser and Connor, Saxon and Cameron, Andrew and Jamieson, Nigel and Sheen, Amy and Mittal, Anubhav and Samra, Jas and Gill, Anthony and Roberts, Keith and Søreide, Kjetil and Pandanaboyana, Sanjay (2024) Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study. British Journal of Surgery, 111 (4): znae100. ISSN 0007-1323

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Legrini, Assya
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

Pennel, Kathryn A.F. and Hatthakarnkul, Phimmada and Wood, Colin S. and Lian, Guang-Yu and Al-Badran, Sara and Quinn, Jean A. and Legrini, Assya and Inthagard, Jitwadee and Alexander, Peter G. and van Wyk, Hester and Kurniawan, Ahmad and Hashmi, Umar and Gillespie, Michael A. and Mills, Megan and Ammar, Aula and Hay, Jennifer and Andersen, Ditte and Nixon, Colin and Rebus, Selma and Chang, David K. and Kelly, Caroline and Harkin, Andrea and Graham, Janet and Church, David and Tomlinson, Ian and Saunders, Mark and Iveson, Tim and Lannagan, Tamsin R. M. and Jackstadt, Rene and Maka, Noori and Horgan, Paul G. and Roxburgh, Campbell S. D. and Sansom, Owen J. and McMillan, Donald C. and Steele, Colin W. and Jamieson, Nigel B. and Park, James H. and Roseweir, Antonia K. and Edwards, Joanne (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43: 64. ISSN 1756-9966

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Zhang, T.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Wood, C.S.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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New, F.N.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Randzavola, L.O.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Speidel, L.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Brown, A.C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Hall, A.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Saffioti, F.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Parkes, E.C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Edwards, W.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Direskeneli, H.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Grayson, P.C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Jiang, L.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Merkel, P.A.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Saruhan-Direskeneli, G.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Sawalha, A.H.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Tombetti, E.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Quaglia, A.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Thorburn, D.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Knight, J.C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Rochford, A.P.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Murray, C.D.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Divakar, P.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Green, M.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Nye, E.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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MacRae, J.I.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Jamieson, N.B.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Skoglund, P.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Cader, M.Z.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Wallace, C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Thomas, D.C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

See full publications list
Lee, J.C.
Author

Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C. (2024) A disease-associated gene desert directs macrophage inflammation through ETS2. Nature, 630 (8016). pp. 447-456. ISSN 0028-0836

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Title:
A disease-associated gene desert directs macrophage inflammation through ETS2
Creators:
Stankey, C.T. and Bourges, C. and Haag, L.M. and Turner-Stokes, T. and Piedade, A.P. and Palmer-Jones, C. and Papa, I. and Silva dos Santos, M. and Zhang, Q. and Cameron, A. and Legrini, A. and Zhang, T. and Wood, C.S. and New, F.N. and Randzavola, L.O. and Speidel, L. and Brown, A.C. and Hall, A. and Saffioti, F. and Parkes, E.C. and Edwards, W. and Direskeneli, H. and Grayson, P.C. and Jiang, L. and Merkel, P.A. and Saruhan-Direskeneli, G. and Sawalha, A.H. and Tombetti, E. and Quaglia, A. and Thorburn, D. and Knight, J.C. and Rochford, A.P. and Murray, C.D. and Divakar, P. and Green, M. and Nye, E. and MacRae, J.I. and Jamieson, N.B. and Skoglund, P. and Cader, M.Z. and Wallace, C. and Thomas, D.C. and Lee, J.C.
Identification Number:
10.1038/s41586-024-07501-1
Date:
13 June 2024
Divisions:
College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:
Nature Research
Additional Information:
This work was supported by Crohn’s and Colitis UK (M2018-3), the Wellcome Trust (Sir Henry Wellcome Fellowship to L.S., 220457/Z/20/Z; Investigator Award to P.S., 217223/Z/19/Z; Senior Fellowship to C.W., WT220788; Clinical Research Career Development Fellowship to M.Z.C., 222056/Z/20/Z; Wellcome-Beit Prize Clinical Career Development Fellowship to D.C.T., 206617/A/17/A; and Intermediate Clinical Fellowship to J.C.L., 105920/Z/14/Z), and the Francis Crick Institute, which receives its core funding from Cancer Research UK (CC2219, FC001595), the UK Medical Research Council (CC2219, FC001595) and the Wellcome Trust (CC2219, FC001595). L.M.H. is supported by the Charité–Universitätsmedizin Berlin and the Berlin Institute of Health Charité (Clinician-Scientist Program); A.J.C. by the Medical Research Council (MR/V029711/1); A.L. by a Lord Kelvin/Adam Smith Leadership Grant; A.H.S. by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH, R01:AR070148); N.B.J. by Cancer Research UK (C55370/A25813); T.Z. by the Chinese Scholarship Council (202308060128); A.Q. by the NIHR UCLH/UCL BRC; J.C.K. by Versus Arthritis (program grant, 20773), Janssen Oxford Translational fellowships and NIHR Oxford BRC; P.S. by the European Molecular Biology Organisation, the Vallee Foundation and the European Research Council (852558); C.W. by the Medical Research Council (MC UU 00002/4), GSK, MSD and the NIHR Cambridge BRC (BRC-1215-20014); and D.C.T. by the Sidharth Burman endowment. J.C.L. is a Lister Institute Prize Fellow.
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https://pub.demo35.eprints-hosting.org/id/eprint/232
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Article
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Unnamed user with email ejo1f20@soton.ac.uk
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Date Deposited:
11 Jun 2025 16:36
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Last Modified:
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